Hydroxylapatite (Ca5(OH)(PO4)3) (HCID 14781)

이름 및 식별자

우선 이름: Hydroxylapatite (Ca5(OH)(PO4)3)
IUPAC: pentacalcium;hydroxide;triphosphate
현지명: 트리염기 칼슘 인산염
영어명: Calcium phosphate tribasic
분자식: 5Ca.3O4P.HO
분자량: 502.31

이름 및 동의어

Durapatite1306-06-5Calcium hydroxyapatiteRadiesseMoniteWin 40350Apatite, hydroxyCalcium hydroxylapatiteSupertite 10Calcium phosphate hydroxideCalcium orthophosphate, basicHydroxylapatite (Ca5(OH)(PO4)3)

이름 더 보기

트리염기칼슘인산염트리염기칼슘인산염(TRIBASICCALCIUMPHOSPHATE)CALCIUM ORTHOPHOSPHATETRI-CALCIUM PHOSPHATEpentacalcium hydroxide tris(orthophosphate)Si-HApALPHA-TCPIc acidtriEinecs 235-330-6TERT-CALCIUM PHOSPHATEHydroxyapatite, powderCELLULOSE HYDROXYAPATIT

Pentacalcium monohydroxyorthophosphateInterpore200Interpore500215-145-7235-330-6Interpore 200Interpore 500Hydroxyapatite, Calcium

데이터베이스 식별자

CAS: 12167-74-7、1306-06-5
PubChem CID: 14781
DTXSID: DTXSID50872537
ChEMBL: CHEMBL2218916
UNII: 91D9GV0Z28
EC Number: 215-145-7、235-330-6

물성

구조 계산 물성

극성 표면적: 260 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 13
회전 가능 결합 수: 0
무거운 원자 수: 21
형식 전하: 0
복잡도: 36

실험 및 물리화학적 성질

DensityDensity: 3.1 to 3.2 /Apatite/

Color/Form · 2건

Hexagonal needles arranged in rosettes

Finely divided, crystalline, nonstoichiometric material.

SolubilityPractically insol in water, even when freshly prepared

Physical Description · 2건

Dry Powder

Solid; [Merck Index] White suspension; [MSDSonline]

Other Experimental PropertiesDecomposes above 1100 °C

물리화학적 성질

녹는점: 1100 °C · 1100 °C(lit.)
밀도: 1.038 g/mL · 1.038 g/mL at 25 °C
저장 조건: 2 · 2-8°C
용해도: 1 M · 1M 염산에 용해됩니다.
물리적 상태: 수성 현탁액
색상: 하얀색
수소이온지수(pH): 4 · 4-6
수용성: 물에 부분적으로 용해됩니다.
Merck: 1694 · 1694
InChI: 1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10
InChIKey: XYJRXVWERLGGKC-UHFFFAOYSA-D
SMILES: [Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O
EPA: Calcium hydroxide phosphate (12167-74-7)

화학적 성질 · 1건

The PhEur 6.4 states that tribasic calcium phosphate consists of a mixture of calcium phosphates. It contains not less than 35.0% and not more than the equivalent of 40.0% of calcium. The USP32– NF27 specifies that tribasic calcium phosphate consists of variable mixtures of calcium phosphates having the approximate composition 10CaO·3P2O5·H2O. This corresponds to a molecular formula of Ca5(OH)(PO4)3 or Ca10(OH)2(PO4)6. Tribasic calcium phosphate is a white, odorless and tasteless powder. col hexagonal crystal(s) [CRC10]

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 97.8% (362 of 370) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 362 of 370 companies (only 2.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 370 reports by companies from 5 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 362 of 370 reports by companies.；There are 3 notifications provided by 8 of 370 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

This chemical does not meet GHS hazard criteria for 94% (188 of 200) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 188 of 200 companies (only 6% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 200 reports by companies from 6 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 188 of 200 reports by companies.；There are 3 notifications provided by 12 of 200 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 5건

Chemical: Hydroxylapatite (Ca5(OH)(PO4)3)

Hydroxylapatite (Ca5(OH)(PO4)3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hydroxylapatite (Ca5(OH)(PO4)3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Cease Manufacture Update: 15-08-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/20278

Status: Active Update: 19-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15208

Hydroxylapatite (Ca5(OH)(PO4)3): Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Hydroxylapatite (Ca5(OH)(PO4)3): Environment tier I assessment；IMAP assessments - Hydroxylapatite (Ca5(OH)(PO4)3): Human health tier I assessment

Hazards SummaryMay cause irritation; [MSDSonline]

Hazard Classes and Categories · 2건

Not Classified

안전 및 보호

Disposal Methods · 1건

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Protective Action Criteria (PAC) · 3건

190 [mg/m3]

2100 [mg/m3]

12000 [mg/m3]

독성 정보

Natural Pollution Sources · 2건

A natural calcium phosphate (usually containing fluorine) occurring in earth's crust as phosphate rock. ... /Occurs in/ Eastern US, California, the former USSR, Canada, Europe. /Apatite/

The major constituent of bone & tooth material.

Human Toxicity ExcerptsDeposition of microcrystals such as ... calcium hydroxyapatite into joints can cause acute or chronic arthritis in a manner similar to that caused by monosodium urate deposition.

Populations at Special RiskCalcium hydroxyapatite deposition disease, or apatite gout, ... usually occurs in younger persons ...

규제 정보

Regulatory Information · 5건

Chemical: Hydroxylapatite (Ca5(OH)(PO4)3)

Hydroxylapatite (Ca5(OH)(PO4)3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hydroxylapatite (Ca5(OH)(PO4)3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Cease Manufacture Update: 15-08-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/20278

Status: Active Update: 19-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15208

Hydroxylapatite (Ca5(OH)(PO4)3): Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk: 3
tsca: Yes
HS 번호: 2835260000
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36-24/25-22
기존화학 물질: KE-04599
스토리지 클래스: 13 - Non Combustible Solids

화학 및 산업

약리 정보

FDA Pharmacological Classification · 2건

CALCAREA PHOSPHORICA

Cations, Divalent [CS]; Phosphate Chelating Activity [MoA]; Calcium [CS]; Blood Coagulation Factor [EPC]; Phosphate Binder [EPC]; Increased Coagulation Factor Activity [PE]

MeSH Pharmacological ClassificationSynthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.

용도 및 제조

Uses · 6건

Naturally occurring mineral in phosphate rocks and in bone; [Merck Index] Used in fertilizers, laser crystals, ion-exchange chromatography (especially for proteins), artificial bone and teeth, and calcium/phosphorus supplement; [HSDB]

Source of phosphorus & phosphoric acid; mfr of fertilizers; laser crystals /Apatite/

USED IN DENTURE & ORTHOPEDIC MATERIALS; USED IN ION-EXCHANGE CHROMATOGRAPHY ESPECIALLY FOR PROTEINS

MEDICATION

Prosthetic aid (artificial bone and teeth).

For more Uses (Complete) data for HYDROXYAPATITE (6 total), please visit the HSDB record page.

U.S. Production2023: 10,000,000 - <50,000,000 lb；2022: 10,000,000 - <50,000,000 lb；2021: 10,000,000 - <50,000,000 lb；2020: 10,000,000 - <50,000,000 lb

Consumer UsesNot Known or Reasonably Ascertainable；Filler

Industry UsesProcessing aids not otherwise specified；Filler；Soil amendments (fertilizers)；Stabilizing agent

Methods of Manufacturing · 2건

Prepd from Ca(NO3)2 and KH2PO4; from calcium phosphate, dibasic; from Ca(NO3)2.4H2O and (NH4)3PO4 plus NH4OH.

Dense hydroxyapatite ceramics are made by compressing calcium phosphate solids from a very fine powder form, known as greenstate, into a pellet which is then subjected to a heat treatment that causes the powder particles to fuse together by means of solid-state diffusion.

Household ProductsInformation on 13 consumer products that contain Calcium phosphate hydroxide in the following categories is provided:；• Landscaping/Yard

응용 분야 · 2건

용도Calcium phosphate tribasic (C3161) is plant cell culture tested (0.2 mg/ml) and is appropriate for use in plant cell culture experiments. Calcium phosphate tribasic is utilized to engineer new biomaterials for applications such as bone grafts and fillers.

일반 설명Hydroxyapatite is a key inorganic phosphate that has chemical and structural resemblance to bone. HAp is a popular biomaterial which finds use as a bone or teeth replacement and repair, hard tissue repair.

제조 방법 · 1건

생산 방법Tribasic calcium phosphate occurs naturally as the minerals hydroxylapatite, voelicherite, and whitlockite. Commercially, it is prepared by treating phosphate-containing rock with sulfuric acid. Tribasic calcium phosphate powder is then precipitated by the addition of calcium hydroxide. Tribasic calcium phosphate is alternatively prepared by treating calcium hydroxide from limestone with purified phosphoric acid. It may also be obtained from calcined animal bones. Some tribasic calcium phosphate products may be prepared in coarser, directly compressible forms by granulating the powder using roller compaction or spray drying.