Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
산화 철(III)
CROCUS(철) · TURKEY적 · 산화제2철 · 산화철(3+) · 산화철(III) · 삼산화철 · 삼이산화철 · 적색산화철
식별자 및 물리적 특성
| CAS No. | 1309-37-1 |
|---|---|
| 분자식 | Fe2O3 |
| 평균 분자량 | 159.69 g/mol |
| SMILES | [Fe+3].[Fe+3].[O-2].[O-2].[O-2] |
| InChIKey | LIKBJVNGSGBSGK-UHFFFAOYSA-N |
| PubChem CID | 14833 |
| EC No. | 215-275-4 |
| 현지명 | 산화 철(III) |
화학 및 물리적 성질
| 극성 표면적 | 3 |
|---|---|
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 5 |
| 형식 전하 | 0 |
| 복잡도 | 0 |
| Polymers | Plastics -> Polyolefin-IPURPolyolefin-IIPVC (soft)ABSPVC (rigid)PETPMMAPAPC(E)PSPlastics -> Pigments agents |
| 밀도 | 5.255.24 |
| Color/Form | Brilliant black to blackish red or brick red mineral, brown to cherry red streak and metallic to dull luster /Hematite, red/Red-brown hexagonal crystals |
| 용해도 | Insol in watersol in hydrochloric acid, sulfuric acidslightly sol in nitric acid따뜻한 염산에 용해되고 황산에 약간 용해됩니다. |
| 녹는점 | 1565 °C1538°C |
| 굴절률 | Index of refraction: 3.19, 2.91 (LI) |
| Physical Description | Large CrystalsDry Powder |
| Other Experimental Properties | Mohs hardness about 6specific gravity: 4.9-5.3 /Hematite, red/ |
| 인화점 | >230 °F |
| 저장 조건 | 2-8°C |
| 물리적 상태 | 플레이크 크리스탈 |
| 색상 | 검은색 |
| 비중 | 5.1~5.2 |
| pH | 3.7±0.3 |
| 용해도 | 불용성 |
| 비열 | Cp(crystal): 0.65 J/(g·K), at 25℃ |
| Merck | 14,4028 |
| 안정성 | 안정적인. |
| 주요 응용 | 배터리 제조 |
| 화장품 원료 기능 | 색소 |
| InChI | 1S/2Fe.3O |
| InChIKey | JEIPFZHSYJVQDO-UHFFFAOYSA-N |
| SMILES | O=[Fe]O[Fe]=O |
| NIST | Iron(iii) oxide(1309-37-1) |
| EPA | Ferric oxide (1309-37-1) |
화학적 성질
Hematite is a noncombustible, black to black red or brick-red mineral (iron ore) composed mainly of ferric oxide, Fe2O3. Ferric oxide
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 88% (402 of 457) of all reports.DangerH315 (12%): Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P280, P302+P352, P305+P354+P338, P317, P321, P332+P317, and P362+P364 (click each P-code to see the statement)Aggregated GHS information provided per 457 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Chemical: Hematite (Fe2O3)Hematite (Fe2O3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hematite (Fe2O3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 19-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/7586Hematite (Fe2O3): Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | IMAP assessments - Hematite (Fe2O3): Human health tier I assessment |
| 화재 가능성 | Noncombustible, except as powder. /Hematite, red/ |
| Hazard Classes and Categories | Skin Irrit. 2 (12%) |
| Skin, Eye, and Respiratory Irritations | If inhaled, iron is a local irritant to the lung and gastrointestinal tract. /Iron compounds/ |
| 처리 방법 | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.The following wastewater treatment technologies have been investigated for iron (Fe+2): Concentration process: Biological treatment. /Iron (Fe+2)/ |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.All ... /iron/ preparations should be kept in child-proof bottles. /Iron preparations/ |
| Threshold Limit Values (TLV) | 8 hr Time Weighted Avg (TWA): 5 mg/cu m (respirable fraction). /Iron oxide/Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Iron oxide/A4: Not classifiable as a human carcinogen. /Iron oxide/ |
| 상호 작용 | Particulate matter & polynuclear aromatic hydrocarbons are known to be cocarcinogenic. Fluorescence spectroscopy showed that adsorption of benzo(a)pyrene to iron oxide (hematite), silica & asbestos (anthophyllite & canadian chrysotile) results in a greatly enhanced rate of benzo(a)pyrene uptake into rat liver microsomes when compared to uptake from aqueous dispersions of benzo(a)pyrene microcrystals.The effects of quartz, Fe2O3 (hematite), CaCO3, & Na feldspar, on host defenses against bacterial pulmonary infection was investigated. Mice which received intratracheal instillations of 10, 33, and 100 mug/mouse were exposed within an hour to aerosols of viable streptococcus, & pneumonia-induced mortality was measured. At 33 and 100 mug/mouse, all particles significantly increased mortality. At the lower dose, only fe2o3 caused a significant increase in mortality. Delaying the challenge did not significantly alter the response. |
| Natural Pollution Sources | Alpha-form occurs in nature as mineral hematite. Gamma-form occurs in nature as mineral maghemite... |
| Human Toxicity Excerpts | /HUMAN EXPOSURE STUDIES/ ...Hematite pneumoconiosis in Cumberland Fe ore miners... is progressive, massive fibrosis, appearing as modified form of infective pneumoconiosis... tuberculosis is terminal event... because of... increases in degree of silica exposure. Increased incidence of lung tumors... of 238 necropsies... 24 cases of carcinoma.../HUMAN EXPOSURE STUDIES/ ...Under the conditions of heavy exposure to hematite dust, pulmonary clearance mechanisms may be overwhelmed. ... Upper lobes & upper parts of lower lobes tend to be more affected by fibrosis than lower parts of lower lobes. Also, peripheries of lungs tend to be more affected than central regions./HUMAN EXPOSURE STUDIES/ Higher concentration of silica & iron ... found in lungs of hematite miners with fibrosis (associated or not with pulmonary tuberculosis) or with bronchial carcinoma than in lungs of those with no such pathology ... levels in those with carcinoma ... not higher than ... those with fibrosis (accompanied or not by tuberculosis) but no carcinoma./HUMAN EXPOSURE STUDIES/ ... Dust ... caught in respiratory tract ... /removed/ in sputum ... rust colored. Remaining iron oxide accumulates in lymphoid tissue, along bronchi around blood vessels, or at bifurcation of bronchi. If worker exposed to iron oxide is short of breath or has abnormal lung function indices, it is important to discover whether or not he has inhaled fibrogenic dust such as silica in addition to iron. /iron/For more Human Toxicity Excerpts (Complete) data for HEMATITE (11 total), please visit the HSDB record page. |
| Carcinogen Classification | HaematiteGroup 3: Not classifiable as to its carcinogenicity to humansVolume 1: (1972) Some Inorganic Substances, Chlorinated Hydrocarbons, Aromatic Amines, N-Nitroso Compounds, and Natural Products1987 |
| Non-Human Toxicity Excerpts | /LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Tracheal organ cultures from guinea pig and hamster were used to document morphologic changes in the differentiated tracheal epithelium after exposure to equal amounts of hematite, crocidolite, and chrysotile. In addition, an epithelial cell line derived from a neonatal hamster trachea (HTE-b) was used to exam alterations in DNA synthesis & the interaction of cells in monolayer with the dusts. Dose-dependent cytotoxicity was observed in both systems after exposure to asbestos, whereas hematite was nontoxic./LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Biochemical alterations in guinea pig lungs caused by hematite dust were followed at 150 days after intratracheal administration of the dust. In vivo dust exposure caused a significant increase in mitochondrial protein content and cytochrome c oxidase activity whereas diaphorase activity remained unaltered. Mitochondria from the exposed animals were apparently in a swollen state and their contraction profile upon the addition of ATP reflected permeability changes. However, in vitro dust caused no significant alterations. Significant increases in glycogen content along with an insignificant decrease in glycogen phosphorylase activity were also observed in hematite-treated guinea pig lungs. Decrease in drug-metabolizing enzymes such as aniline hydroxylase and tyrosine aminotransferase activities were also evident in the postmitochondrial fraction of the siderotic lungs. [3H]Leucine-incorporation studies showed increased protein synthesis in the postmitochondrial fraction. Increase in protein synthesis in mitochondria was only marginal whereas in whole homogenate it decreased considerably. Experiments employing dust tagged with radioactive iron indicated the rapid mobilization of iron from lung and its distribution to various organs. The presence of iron-binding protein was confirmed by employing Sephadex gel-filtration techniques./LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ The changes in activities of glucose-6-phosphate dehydrogenase, fructose diphosphatase, adenyl cyclase, succinic dehydrogenase and carbonic anhydrase were followed in guinea pig lungs at 50, 100 and 150 days after an intratracheal injection of 50 mg hematite dust. Fructose diphosphatase was elevated and adenyl cyclase unaffected, while the other activities decreased./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ ... Failed to increase frequency of lung tumors in guinea-pigs by exposing them to hematite dust.For more Non-Human Toxicity Excerpts (Complete) data for HEMATITE (9 total), please visit the HSDB record page. |
| Evidence for Carcinogenicity | A4: Not classifiable as a human carcinogen. /Iron oxide/Classification of carcinogenicity: 1) evidence in humans: Inadequate2) evidence in animals: Inadequate. Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. /From table/ |
| Probable Routes of Human Exposure | NIOSH (NOES Survey 1981-1983) has statistically estimated that 28,186 workers (563 of these are female) are potentially exposed to hematite in the US(1). |
| Antidote and Emergency Treatment | Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. /Iron and related compounds/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with lactated Ringer's /SRP: "To keep open", minimal flow rate/. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Iron and related compounds/Maintain an open airway and assist ventilation if necessary. Treat shock caused by hemorrhagic gastrointestinitis aggressively with intravenous crystalloid fluids, and replace blood if needed. Patients are often markedly hypovolemic owing to gastrointestinal losses and third spacing of fluids into the intestinal wall and interstitial space. Treat coma, seizures, and metabolic acidosis if they occur. For seriously intoxicated victims (eg, shock, severe acidosis, and/or serum iron > 500-600 mcg/dL) administer deferoxamine. Monitor the urine for the urine for the characteristic orange or pink deferoxamine-iron complex. Therapy may be stopped when the urine returns to normal or when the serum iron level decreases to the normal range. Prolonged deferoxamine has been associated with adult respiratory distress syndrome and Yersinia sepsis.Activated charcoal is not effective. Ipecac is not recommended, because it can aggravate iron-induced gastrointestinal irritation and interfere with whole bowel irrigation. Consider gastric lavage if product was a liquid formulation or tablets were chewed. Do-not use phosphate-containing solutions for lavagethese may result in life-threatening hypernatremia, hyperphosphatemia, and hypocalcemia. Bicarbonate and deferoxamine lavage are of doubtful efficacy. Deferoxamine lavage is not effective and may enhance iron absorption. Whole-bowel irrigation is very effective for ingested tablets and may be considered first-line treatment, especially if large numbers of tablets are visible on plain abdominal x-ray. Massive ingestions may lead to concretions or bezoars. Repeated or prolonged whole-bowel irrigation may remove tablets. Endoscopy or surgical gastrotomy is rarely required.Hemodialysis and hemoperfusion are not effective for removing iron but may be necessary to remove iron-deferoxamine complex in patients with renal failure. Exchange transfusion is occasionally used for massive pediatric ingestions but is of questionable efficacy. |
| 직업 노출 등급(OEB) | B |
| 직업 노출 한계(OEL) | TWA: 5 mg/m3 |
| 수질 위해 등급(WGK) | - |
| 즉시 생명 위험 농도 | 2,500 mg Fe/m3 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | NO7400000 |
| 관세 코드 | 28211000 |
| 위험 문구(R) | 36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 26 |
| 기존화학 물질 | KE-10897 |
| 저장 분류 | 13 - Non Combustible Solids |
| 유해 물질 데이터 | 1309-37-1(Hazardous Substances Data) |
용도
개요
Iron oxides are produced synthetically and consist essentially of anhydrous and/or hydrated iron oxides. The range of hues includesyellows, reds, browns and blacks. Food quality iron oxides are primarily distinguished from technical grades by the comparatively low levels of contamination by other metals. This is achieved by the selection and control of the source of iron and/or by the extent of chemical purification during the manufacturing process. Iron oxides have been used to color confectionery, fillings and decorations for pastry products, cheese products, fish paste, pet foods, cosmetics and pharmaceutical products.
출처
Iron(III) oxide occurs in nature as the mineral hematite. It is the principal ore of iron from which the metal and its alloys are produced. Also, this oxide occurs in the mineral, limonite, 2Fe2O33H2O. An important application of this compound involves producing red, orange, and yellow pigments. Other applications are in coatings for metals, steel and rubber; in ceramics; and as a catalyst for oxidation reactions.
용도
Ferric Oxide is a nutrient and dietary supplement that is a source of iron.
제조 및 합성 방법
제조 방법
Iron(III) oxide is prepared as a reddish-brown hydrated precipitate by treating an aqueous solution of an iron(III) salt with caustic soda: 2FeCl3 + 6NaOH → Fe2O33H2O + 6NaCl It also is obtained by thermal decomposition of iron(II) sulfate or the brown oxide hydroxide: 2FeSO4 → Fe2O3 + SO2 + SO3 2FeO(OH) → Fe2O3 + H2O The oxide is prepared in industrial scale by first precipitating iron(II) hydroxide Fe(OH)2 by treating aqueous solutions of iron(II) sulfate and caustic soda. The Fe(OH)2 is then oxidized to iron(III) hydroxide by aeration. The latter is dehydrated by heating: Fe2+ (aq) + OHˉ (aq) → Fe(OH)2(s) → 2Fe(OH)3 → Fe2O3 + 3H2O It also is produced by ignition of iron(III) oxalate and iron carbonyls: 2Fe2(C2O4)3 +3O2 → 2Fe2O3 + 12CO.