Ngb-2849

HCID 15411150CAS 197242-80-1

부분 구조 검색 유사 구조 찾기

기본 정보

표준 SMILES: O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cc3ccccc3cc2c1
InChIKey: ZITQUAHPZJHCJH-UHFFFAOYSA-N
분자식: C29H29Cl2N3O
평균 분자량: 506.5 g/mol

개요

a dopamine D3 receptor antagonist; structure in first source

이름 및 식별자

우선 이름: Ngb-2849
IUPAC: N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]anthracene-2-carboxamide

이름 및 동의어

NGB284926P8N956NZNGB-2849197242-80-1RefChem:927696NGB 2849UNII-26P8N956NZN-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyl)-2-anthracenecarboxamide2-Anthracenecarboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)-N-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl}-2-anthracenecarboxamideorb1739455SCHEMBL8183795

이름 더 보기

ZITQUAHPZJHCJH-UHFFFAOYSA-N

데이터베이스 식별자

CAS: 197242-80-1
PubChem CID: 15411150
UNII: 26P8N956NZ
Nikkaji: J959.637B

물성

구조 계산 물성

XLogP: 7
극성 표면적: 35.6 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 3
회전 가능 결합 수: 7
무거운 원자 수: 35
형식 전하: 0
복잡도: 685

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 1건

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.