이셀레늄화디페닐
이셀레늄화디페닐 · 1,2-Diphenyldiselane · PHENYL DISELENIDE · diseL · Two phenyltwo se · diphenyl-diselenid · diphenyl disenenide · DIPHENYL DISELENIDE
식별자 및 물리적 특성
| CAS No. | 1666-13-3 |
|---|---|
| 분자식 | C12H10Se2 |
| 평균 분자량 | 312.1 g/mol |
| 단동위원소 질량 | 313.91129292 g/mol |
| SMILES | c1ccc([Se][Se]c2ccccc2)cc1 |
| InChIKey | YWWZCHLUQSHMCL-UHFFFAOYSA-N |
| PubChem CID | 15460 |
| ChEMBL | CHEMBL3122204 |
| ChEBI | CHEBI:232541 |
| EC No. | 216-780-2 |
| DTXSID | DTXSID6061864 |
| 현지명 | 이셀레늄화디페닐 |
화학 및 물리적 성질
| 극성 표면적 | 0 |
|---|---|
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 0 |
| 회전 가능 결합 수 | 3 |
| 무거운 원자 수 | 14 |
| 형식 전하 | 0 |
| 복잡도 | 128 |
| 녹는점 | 60 °C |
| 끓는 점 | 202 °C / 11mmHg |
| 밀도 | 1.5570 |
| 굴절률 | 1.7430 |
| 저장 조건 | Store below +30°C. |
| 물리적 상태 | 가루 |
| 색상 | 노란색 |
| 비중 | 1.84 |
| 용해도 | 불용성 |
| BRN | 2047179 |
| InChI | 1S/C12H10Se2/c1-3-7-11(8-4-1)13-14-12-9-5-2-6-10-12/h1-10H |
| InChIKey | YWWZCHLUQSHMCL-UHFFFAOYSA-N |
| SMILES | [Se]([Se]c1ccccc1)c2ccccc2 |
| NIST | Diselenide, diphenyl(1666-13-3) |
| EPA | Diselenide, diphenyl (1666-13-3) |
화학적 성질
yellow crystalline powder
안전 및 규제
| GHS 분류 | DangerH301 (97.9%): Toxic if swallowed [Danger Acute toxicity, oral]P260, P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P319, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 48 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Chemical: Diselenide, diphenylDiphenyl diselenide: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | Evaluation - Chemicals not considered for in depth evaluation - Not commercially active in Australia |
| Hazard Classes and Categories | Acute Tox. 3 (97.9%) |
| Minimum Risk Level | Chronic Oral: 0.005 mg/kg/day (L134) |
| 건강 영향 | Chronic oral exposure to high concentrations of selenium compounds can produce a disease called selenosis. The major signs of selenosis are hair loss, nail brittleness, and neurological abnormalities (such as numbness and other odd sensations in the extremities). Animal studies have shown that selenium may also affect sperm production and the female reproductive cycle. (L619) |
| 노출 경로 | Oral (L619)inhalation (L619)dermal (L619) |
| 독성 요약 | Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration of sulfur is low. Inactivation of the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, through effects on mitochondrial and microsomal electron transport, might contribute to acute selenium toxicity. Selenomethionine (a common organic selenium compound) also appears to randomly substitute for methionine in protein synthesis. This substitution may affect the structure and functionability of the protein, for example, by altering disulfide bridges. Inorganic forms of selenium appear to react with tissue thiols by redox catalysis, resulting in formation of reactive oxygen species and causing damage by oxidative stress. (L619) |
| Signs and Symptoms | Short-term oral exposure to high concentrations of selenium may cause nausea, vomiting, and diarrhea. Brief exposures to high levels of elemental selenium or selenium dioxide in air can result in respiratory tract irritation, bronchitis, difficulty breathing, and stomach pains. Longer-term exposure to either of these air-borne forms can cause respiratory irritation, bronchial spasms, and coughing. (L619) |
| Carcinogen Classification | 3, not classifiable as to its carcinogenicity to humans. (L135) |
| 수질 위해 등급(WGK) | 3 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | JM9152500 |
| 운송 번호(UN) | UN 3283 6.1/PG 2 |
| 관세 코드 | 2931 90 00 |
| 위험 문구(R) | 23/25-33-50/53 |
| 위험 표시 | T,N |
| 안전 문구(S) | 20/21-28-45-60-61-28A |
| 포장분류 | II |
| 위험 등급 | 6.1Acute Tox. 3 InhalationAcute Tox. 3 OralAquatic Acute 1Aquatic Chronic 1STOT RE 2 |
| 저장 분류 | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
용도
용도
Diphenyl diselenide is used in the methoxyselenenylation of alkenes, dihydroxylation of double bonds, hydrothiolation of terminal alkynes. It is used in the synthesis of the unsymmetrical diorganyl selenides, 1-(phenylselenomethyl)vinyl selenides, allylic phenyl selenides.
일반 설명
Diphenyl diselenide (Ph2Se2) is an organoselenium compound. Its crystalline structure, toxicokinetic properties, antioxidant and anti-inflammatory activities have been investigated. Its ability to reverse the oxidative brain damage and mitochondrial dysfunction induced by acetaminophen has been studied in mice. It reacts with thallium (Tl) to form TI (SePh). It participates in a four-component radical coupling to form substituted cyclopentanes.