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HCID 15546생성일: 2026년 10월 27일

Chloridazon

Chloridazon · PYRAZON · Phenazon · Chloridazone · Trojan · Gladiator · Copolymer of Phosphono and carboxylic Acid · 5-Amino-4-chloro-2-phenylpyridazin-3(2H)-one

https://huagongshe.com/ko/chemical/15546

Chloridazon 분자 구조식

식별자 및 물리적 특성

CAS No.1698-60-8
분자식C10H8ClN3O
평균 분자량221.64 g/mol
단동위원소 질량221.0355896 g/mol
SMILESNc1cnn(-c2ccccc2)c(=O)c1Cl
InChIKeyWYKYKTKDBLFHCY-UHFFFAOYSA-N
PubChem CID15546
ChEMBLCHEMBL1525705
ChEBICHEBI:81838
EC No.216-920-2
DTXSIDDTXSID3034872

화학 및 물리적 성질

XLogP0.8
극성 표면적58.7
수소 결합 공여자 수1
수소 결합 수용자 수3
회전 가능 결합 수1
무거운 원자 수15
형식 전하0
복잡도332
SpringerMaterials PropertiesFusion temperature
농약HerbicidesActive substance -> EU Pesticides database: Not approvedPesticides -> Herbicides, OtherPesticides -> Herbicides -> Pyridazinone herbicidesEnvironmental transformation -> Pesticides (parent, predecessor)
LogP(분배 계수)log Kow = 1.141.19
냄새Odorless
밀도1.54 g/cu cm at 20 °C1.4884 (rough estimate)
Color/FormColorless solid
용해도IN WATER 400 MG/L AT 20 °CIN METHANOL 34 G/KG AT 20 °CIN ACETONE 28 G/KG AT 20 °CIN BENZENE 0.7 G/KG AT 20 °CIN CYCLOHEXANE GREATER THAN 0.01 G/100 G @ 20 °CIN CHLOROFORM 0.21 G/100 G @ 20 °CIN ETHER 0.07 G/100 G @ 20 °CIn distilled water, 340 mg/L at 20 °CIn methanol 15.1, ethyl acetate 3.7, dichloromethane 1.9, toluene 0.1 (all in g/l at 20 °C)Practically insoluble in n-hexane.In water, 400 mg/L at 20 °C25.5 [ug/mL] (The mean of the results at pH 7.4)Chloroform (Slightlly), DMSO (Sparingly), Methanol (Slightly)
CorrosivityNONCORROSIVE
Human DrugsPharmaceuticals
녹는점206 °CMELTING POINT: 185-195 °C /TECHNICAL PRODUCT/Brown, almost odorless. MP: 198-202 °C /technical/198-200°C
증기압0.00000045 [mmHg]4.50X10-7 mm Hg at 20 °C
Physical DescriptionColorless odorless solid[HSDB]
끓는 점312.2±52.0 °C(Predicted)
굴절률1.5330 (estimate)
저장 조건Keep in dark place,Inert atmosphere,2-8°C
물리적 상태Solid
pKa(산도 계수)0.71±0.20(Predicted)
색상담황색 고체
용해도0.3g/L(20℃)
BRN397241
헨리 상수3.0×104 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
InChIInChI=1S/C10H8ClN3O/c11-9-8(12)6-13-14(10(9)15)7-4-2-1-3-5-7/h1-6H,12H2
InChIKeyWYKYKTKDBLFHCY-UHFFFAOYSA-N
SMILESC1(=O)N(C2=CC=CC=C2)N=CC(N)=C1Cl
LogP(분배 계수)1.140
EPAPyrazon (1698-60-8)

화학적 성질

Brown Solid

안전 및 규제

GHS 분류WarningH317: May cause an allergic skin reaction [Warning Sensitization, Skin]P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement)H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
규제 정보Commission Regulation (EC) No 1490/2002Pyrazon is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)2008/41, Reg. (EU) 2022/801, Reg. (EU) No 540/2011Chloridazon: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보IMAP assessments - 3(2H)-Pyridazinone, 5-amino-4-chloro-2-phenyl-: Environment tier I assessment
화재 가능성DRY POWDER, NONFLAMMABLE.
유해성 요약Repeated exposure may cause skin rashesCase reports of slight liver enlargement[HSDB] May cause skin sensitization[eChemPortal: ESIS] May cause irritationMay cause skin sensitization[MSDSonline]
Special ReportsUSEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - Pyrazon EPA 738-F-05-014 (September 2005). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of February 27, 2007: http://www.epa.gov/pesticides/reregistration/status.htm]
FIFRA 요건Tolerances are established for combined residues of the herbicide pyrazon (5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone) and its metabolites (calculated as pyrazon) in or on the following food commodities: [Table#3543]The Agency made its reregistration eligibility determination based on the required data, the current guidelines for conducting acceptable studies to generate such data, and published scientific literature. The Agency has found that currently registered uses of pyrazon are eligible for reregistration.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Pyrazon is found on List B. Case No: 2570

용도

용도

Herbicide, active by perturbing cell membranes

Pesticide type: insecticide, herbicide
Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.
Active ingredient (AI): 5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone
Data Call-in (DCI) Date(s): 06/11/91
AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.
Hazard Classes and CategoriesSkin Sens. 1 (100%)Skin sensitisation - category 1Hazardous to the aquatic environment (Acute) - Category 1
처리 방법SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.
Preventive MeasuresRemove contaminated clothing and wash skin with soap and waterAVOID CONTACT WITH SKIN, EYES & CLOTHING.Do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate water when disposing of equipment washwater or rinsate. ... Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application. ... Do not apply this product through any type of irrigation system. Delete any application instructions /on the product labels/ referring to use with irrigation equipment.Users should wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet.Users should remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. Users should remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing. Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.
Allowable TolerancesTolerances are established for combined residues of the herbicide pyrazon (5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone) and its metabolites (calculated as pyrazon) in or on the following food commodities: [Table#3542]
Personal Protective Equipment (PPE)Handler PPE requirements established by the RED for all pyrazon products. All mixers, loaders, applicators, and other handlers must wear: long-sleeved shirt, long pants, shoes and socks.Restricted-Entry Interval: Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 hours. Early Entry Personal Protective Equipment established by the RED: ... minimum ... PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, is: coveralls, shoes plus socks, chemical-resistant gloves made of any waterproof material.Pilots must use an enclosed cockpit that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)].
상호 작용In the presence of 10 mmol sodium thiocyanate and 0.1 mole sodium nitrite at pH 1 (similar to stomach conditions), 10 mmol pyrazon reacts to n-methyl-nitroso-aniline. When mutagenicity was tested using Escherichia coli K-12 (343/113) in an in vitro system, pyrazon was not mutagenic. The derivatives induced mutations in the presence of metabolically active liver microsomes.
생태독성 수치LD50Species: Apis mellifera (Honey bee) topical >193 ug/beeLC50 Salmo (trout) 27 mg/L for 96 hr (65% wettable powder formulation) /condiitions of bioassay not specified/
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), Koc values ranging from 33(2) to 380(3) indicate that pyrazon is expected to have very high to high mobility in soil(SRC). Volatilization of pyrazon from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.3X10-10 atm-cu m/mole(SRC), derived from its vapor pressure, 4.5X10-7 mm Hg(4), and water solubility, 400 mg/L(5). Pyrazon is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). On soil, a photolysis half-life of 69 days has been reported(6). An aerobic biodegradation half-life of up to 152 days (anaerobic metabolism of 307-607 days depending on soil texture) suggests that biodegradation is not an important environmental fate process in soil(6).TERRESTRIAL FATE: Pyrazon persistence in soil has been reported as: approximately 6-8 weeks under sufficiently moist conditions(1)6-7 month at application rates of 4 ppm(5)and 3-6 months at recommended application rates(5). Reported half-lives in soil are 21 days(6) and 10 days in loam soil at 20 °C(4). In a silty clay loam soil (pH 7.7, 1.28% organic carbon) with a 22% water content, the half-lives of pyrazon were 75.6, 21.3, and 13.6 days at 10 °C, 20 °C, and 30 °C, respectively(2). The half-life increased as the water content of the soil decreased(2). At 10 °C, the half-lives were 133.7 and 41.0 days at 15% and 29% soil water content. At 30 °C, the half-lives were 12.2 and 7.9 days at 15% and 29% soil water content, respectively. In field studies in Northern Italy in which 2.2 liters/hectacre of pyrazon were applied pre-emergence with a tractor sprayer with soil sampling performed over 80 days, the disappearance half-life, assuming first-order kinetics, was 68.3 days(2). After 80 days, 36.9% of pyrazon remained in the 0-5 cm layer of soil. The total recovery for all soil layers was 47%. These studies indicate that in the absence of high rainfall, degradation is the main loss process(2). Pyrazon residues were evident at 5-10 cm, 3 days after application but did not reach significant concns at 10-20 cm until 63 days. After 80 days, 3.94% and 8.96% of the applied herbicide was found at 5-10 cm and 10-20 cm depth(2).TERRESTRIAL FATE: When pyrazon was applied at pre-emergence 1.30 kg/ha to a field plot of sugar beets as formulated products according to normal agricultural practice in spring 1992, typical concns in drain water during spring/summer flows were 0.03 to 0.15 ug/L(1). The field plot in Germany contained loamy silt soil (1.0% Organic Content) and had subsurface drains spaced at 5 to 9 m at an average depth of 80 to 110 cm. Pyrazon was sprayed uniformly by aerial application on two small field plots (25X10 m) in Elazig, Turkey, containing agricultural land never treated with pesticidesoil samples analyzed within a 6-month period showed pyrazon levels of 2.9 and 0.7 mg/kg at the 0-5 cm and 15-20 cm depth, respectively, following an application rate of 3.25 kg active ingredient/ha(2).AQUATIC FATE: Based on a classification scheme(1), Koc values ranging from 33(2) to 380(3) indicate that pyrazon is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 3.3X10-10 atm-cu m/mole(SRC), derived from its vapor pressure, 4.5X10-7 mm Hg(5), and water solubility, 300 mg/L(6). According to a classification scheme(7), a BCF range of 2-23(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Pyrazon is stable to hydrolysis at pH 5, 7, and 9, with the major route of degradation in water appearing to be photolysis, half-life of 12.5 days(9). A biodegradation half-life of up to 152 days suggests that biodegradation is not an important environmental fate process(9).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), pyrazon, which has a vapor pressure of 4.5X10-7 mm Hg at 20 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase pyrazon is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 10 hours(SRC), calculated from its rate constant of 4.0X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase pyrazon may be removed from the air by wet or dry deposition(SRC). Pyrazon half-life in simulated sunlight (xenon lamp. 210 uEinstein sq m/sec) was 150 hrs at pH 7, in water(4). A major route of degradation in water appears to be photolysis, with a half-life of 12.5 days reported(5).
유해 작용Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
독성 요약Pyrazon [5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone], also known as chloridazon, is an herbicide belonging to the pyridazinone class of pesticides. It works as an herbicide by blocking electron transport in photosystem II in green plants, thereby inhibiting photosynthesis. Pyrazon is registered for pre-plant, pre-emergence, and early post-emergence use on sugar beets and red table beets to control certain weeds. Approximately 10% of the U.S. sugar beet crop and 50% of the U.S. table beet crop are treated with pyrazon annually. Pyrazon is also registered for commercial use on ornamentals, including bulb crops and roses. The available toxicity data on pyrazon are adequate to assess the chemical's hazard potential. Pyrazon is an herbicide considered to be of low toxicity without highly specific responses in mammals. Technical pyrazon has low (category III/IV) acute toxicity via the oral, dermal, and inhalation routes of exposure. It is not an eye or skin irritant (category IV) and does not cause dermal sensitization. In longer-term studies, reduced body weight associated with reduced food consumption appears to be the most significant effect of pyrazon exposure in laboratory animals. At higher doses, conditions such as poor general appearance and some motor effects considered to be associated with poor nutrition are noted in rats. In dogs, renal distal tubule vacuolation results at higher doses. No systemic effects resulted from dermal exposure to pyrazon. In both the rat and rabbit prenatal developmental studies, pyrazon did not demonstrate any effects on the fetuses to indicate increased susceptibility. There were no effects on the reproductive performance of rats. Based on the lack of pre- and/or postnatal susceptibility resulting following exposure to pyrazon, and considering the lack of residual uncertainties for pre- and/or postnatal toxicity, no special FQPA safety factor is needed. Therefore, the special FQPA safety factor was reduced to 1X. No neurobehavioral alterations or evidence of neuropathological effects were observed in the available rat and rabbit prenatal developmental toxicity studies or the rat multi-generation reproduction study. In addition, pyrazon is not considered to be neurotoxic from other guideline studies or in open literature reports. Some clinical signs suggesting neurotoxicity were noted at very high doses in the rat, but these were attributed to the weight loss and general poor condition of the rats. Based on the weight of evidence, a developmental neurotoxicity (DNT) study is not required for pyrazon. Pyrazon may be classified as "not likely to be a carcinogen in humans" based on the lack of evidence of carcinogenicity in the rat and mouse carcinogenicity studies.
생태독성 발췌/BIRDS and MAMMALS/ Birds. The Registrant submitted studies satisfy /EPA/ test guidelines for avian acute oral toxicity (71-1) and avian dietary toxicity (71-2). The oral study conducted with bobwhite quail (Acceptable /to EPA/) yields an oral LD50 of >2,000 mg a.i./kg body weight and an acute oral NOAEL > 1000 mg ai/kg body weight. The dietary studies conducted with mallard duck and bobwhite quail show an LC50 of > 5000 ppm diet for bobwhite quail (Acceptable) and 4254 mg ai/kg diet for mallard duck (Acceptable). Additionally, based on these studies, the dietary NOAEC is 625 mg ai/kg diet (for both Mallard and Bobwhite). Therefore, pyrazon is classified as practically nontoxic to avian species on either an acute oral or an acute dietary basis./BIRDS and MAMMALS/ There are exceedances of the acute endangered species LOC (level of concern) for listed birds with every modeled maximum application rate use scenario. There is a potential concern for listed birds species for which the acute LOC is exceeded and for listed species that may be dependent upon birds with LOC exceedances. These concerns are limited to situations where exposure to the stressor actually occurs. Acute RQs (Risk quotients) exceed the endangered species LOC for listed species of mammals for all the maximum use rate scenarios, except for the lowest rate (1.69 lbs a.i./A). The RQs range from 0.1 to 0.4. There are some chronic RQs that exceed the LOC for all the maximum use rate scenarios. RQs range from 1 to 76. There is potential concern for mammalian species for which the LOC is exceeded and for listed species for which there is dependency upon mammals with LOC exceedances. These concerns are limited to situations where exposure to the stressor actually occurs. EPA does not expect pyrazon to pose a significant chronic risk to mammals.../AQUATIC SPECIES/ The compound was also dangerous to fish, esp the young, @ 50 mg/L in aquaria, it produced 100% mortality in 3 days among crucian carp and guppies./AQUATIC SPECIES/ Two studies (test species rainbow trout, and bluegill sunfish /acceptable to EPA/ were submitted to establish the toxicity of pyrazon to freshwater fish. These studies satisfy the guideline requirements for Fresh Warm Water Fish Acute Toxicity (72-1c) and Fresh Cold Water Fish Acute Toxicity (72-1a), respectively. The data show 96-hour LC50 values of 88.7 mg a.i./L in bluegill sunfish and >32 but <46 mg ai/L in rainbow trout. Based on these values, pyrazon is categorized as slightly toxic to freshwater fish on an acute basis. Taking the most conservative approach, this assessment uses the lowest LC50 of 32 mg a.i./L of the rainbow trout as a surrogate to evaluate acute toxic exposure to all freshwater fish species. Using this value may result in an overestimation of risk since the true LC50 is higher than 32 mg ai/L. One acute toxicity study was conducted with the rainbow trout using the principle metabolite B-1. This study (Acceptable) was conducted with rainbow trout. The 96-hour LC50 from this study was >105.5 mg a.i./L Since metabolite B-1 appeared to be less toxic than the parent compound, pyrazon, risks associated with potential exposures to metabolite B-1 were not evaluated quantitatively in this assessment.For more Ecotoxicity Excerpts (Complete) data for PYRAZON (11 total), please visit the HSDB record page.
Soil Adsorption/MobilityReported Koc values of pyrazon are 120(1), 110(2), 89-340(3) and 33(4). According to a classification scheme(5), this estimated Koc value suggests that pyrazon is expected to have very high to high mobility in soil. Pyrazon does not readily leach through clay, clay loam, sandy loam, sandy clay, or loam soil(6).The soil-water distribution constant, Kd, of pyrazon to 18 natural surface soils from west central Spain ranged from 0.07 to 5.96 at an equilibrium, concn of 225 ug/mL(1). The study showed the effect of both soil organic matter and smectite content on adsorptivity(1). The slope of the adsorption isotherm was higher for soils with a higher organic matter content or smectite content(1). Aside from the soil with the very high Kd of 5.96, Kd values between 0.54 and 1.73 were obtained from samples with %OC >2.8% or smectite content >8%. Kd values between 0.14 and 0.51 were obtained from samples with %OC between 0.7 and 2.8% or with smectite content <8%. Kd values <0.14 were obtained from samples with %OC <0.7% and without smectite in the clay fraction. Adsorption of pyrazon by oxidized soils, montmorillonite, a clay mineral of the smectite group, and humic acids confirm the effect of organic matter and smectite content on the adsorption of natural soils(1).Pyrazon was generally slightly mobile when evaluated on 7 soils by thin layer chromatography (TLC)(1). However it was moderately mobile in one soil and relatively immobile in two other soils. The relative mobilities did not appear to correlate with pH or percent organic matter of the soil(SRC). The resulting Rf values ranged from 0.07 to 0.42 with a mean of 0.18. Pyrazon forms well defined complexes with montmorillonite(2). According to IR spectra, the N atom of the pyridazone ring and/or the C=O group are involved in the interaction(2).
Human Toxicity Excerpts/SIGNS AND SYMPTOMS/ Skin rashes ... are common after repeated exposures.../CASE REPORTS/ ... When Burex production was initiated in Czechoslovakia, a number of cases of worker injury occurred. Clinical and laboratory findings are reported for seven workers injured by the Burex precursors PCC (1-phenyl-4,5- dichlopyridazone-6) and MCA (mucochloric acid). Contact with these substance produced acute local irritation which gradually developed the character of a second-degree burn. Six to ten days later, when the local changes were beginning to resolve, systemic manifestations began. They were mainly characterized by digestive disorders and by slight liver enlargement in patients with more extensive local injuries. Certain biochemical factors were altered in all patientsSGPT and LDH were increased and serum proteins, mucoproteins, and protein fractions were abnormal for up to 2 months. Photosensitization was also noted. /Burex precursors//CASE REPORTS/ Poison Control Center Data - 1993 through 2003 A total of 4 cases were located in Poison Control Center records from 1993 through 2003. Three involved ingestion (2 among adults and one child less than six years old) but none of these cases reported any symptoms. The fourth case was an adult seen a health care facility with nausea, classified as an adverse reaction. California Data - 1982 through 2003 - Only one report from 1985 was attributed to exposure to pyrazon. In this case, a hand applicator accidently sprayed his eyes and face with local symptoms only National Pesticide Information Center - On the list of the top 200 chemicals for which NPIC received calls from 1984-1991 inclusively, Pyrazon was not reported to be involved in human incidents.
Fish/Seafood ConcentrationsPyrazon concentrations in zebra mussel (Dreissena polymorpha) and eel (Anguillla anguilla) from various locations along the Rhine and Meuse delta, Germany sampled in 1994 were <20 ug/kg wet weight(1).
Artificial Pollution SourcesPyrazon's production may result in its release to the environment through various waste streamsit's use as a herbicide on some vegetables and ornamentals such as roses(1) will result in its direct release to the environment(SRC).
Environmental BiodegradationIN SANDY LOAM SOIL, LESS THAN 10% OF THE HERBICIDE WAS DEGRADED TO 5-AMINO-4-CHLORO-3(2H)-PYRIDAZINONE (ACP) AFTER 10 WK @ 21 °C ... IN OTHER STUDIES, LOSS OF PYRAZON FROM SOIL WAS EXPONENTIAL & CHARACTERISTIC OF THE ACTIVITY OF SOIL MICROORGANISMS ...IT PERSISTS IN SANDY LOAM FOR ABOUT 20 WK & IS DECOMP TO 5-AMINO-4-CHLORO-PYRIDAZIN-3-ONE WHICH IS NON-PHYTOTOXIC.... DEPENDING UPON SOIL TEMP & MOISTURE IN TREATED ZONE, MICROBIAL BREAKDOWN CAN BE MODERATELY RAPID. PRINCIPAL SOIL DEGRADATION PRODUCT IS DEPHENYLATED PYRAZON WHICH IS NOT SIGNIFICANTLY HERBICIDAL.GRAM-NEGATIVE COCCUS REQUIRING VITAMIN-B12 WAS FOUND CAPABLE OF METABOLIZING PYRAZON. BENZENE MOIETY ... SEEMED TO BE USED AS A CARBON SOURCE. ... RESIDUE OF 5-AMINO-4-CHLORO-PYRIDAZIN-3(2H)-ONE /WAS DETECTED/. ... SOIL MICROORGANISMS ... /COULD REMOVE/ PHENYL GROUP ...For more Environmental Biodegradation (Complete) data for PYRAZON (8 total), please visit the HSDB record page.
Sediment/Soil ConcentrationsSOIL: The concn of pyrazon at four sites in central Chile after treatment was determined by taking integrated core samples up to 30 cm in depth along transects. The results were (time after treatment, concn): 14 days, 590 ppb87 days, 9.5 ppb205 days, 4.1 ppb236 days, 5.1 ppb277 days, 2.3 ppb(1).SEDIMENT: Pyrazon concentrations in suspended solids from the Rhine and Meuse delta, Germany were 0.12 and 0.075 ug/kg dry weight organic matter, respectively, sampled from 1993-1994.
수질 위해 등급(WGK)2
TSCA 등재 상태TSCA listed
RTECS 번호UR6125000
운송 번호(UN)3077
독성LD50 orl-rat: 647 mg/kg FAATDF 7,299,86
관세 코드2933.99.8290
위험 문구(R)43-50/53
위험 표시Xi,N
안전 문구(S)24-37-60-61
위험 등급IRRITANTAcute Tox. 4 OralAquatic Acute 1Aquatic Chronic 1Skin Sens. 1
저장 분류11 - Combustible Solids
유해 물질 데이터1698-60-8(Hazardous Substances Data)