기본 정보
- CAS
11028-71-0- 표준 SMILES
CCCN(CCC)S(=O)(=O)c1ccc(C(=O)O)cc1.Cc1cn(C2CC(N=[N+]=[N-])C(CO)O2)c(=O)[nH]c1=O- InChIKey
RVSZVJZFCQZYHQ-UHFFFAOYSA-N- 분자식
- C23H32N6O8S
- 평균 분자량
- 552.6 g/mol
- 단동위원소 질량
- 552.20023317
개요
Concanavalin A is an organic molecular entity.
이름 및 식별자
- 우선 이름
- Concanavalin A
- IUPAC
- 1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione;4-(dipropylsulfamoyl)benzoic acid
- 영어명
- Concanavalin A
- 분자식
- C15H24
- 분자량
- 0
이름 및 동의어
CONCANAVALIN A11028-71-0Concanavaline ARicintoxin con ACon-ARicin-toxin con ACON ARefChem:388895DTXSID3037202EINECS 234-258-2NSC 143504234-258-2
이름 더 보기
nsc143504Con A/Cy5.5CONCANAVALINCON A TYPE IVA,concanavalinconcanavalineaCONCANAVALIN A TYPEConcanavalin A III
Concanavalin A lectin (Con A)CONCANAVALIN A TYPE IIIConA Type A IVConcanavalin A from Canavalia ensiformis (jack bean)UltraBio? Concanavalin A Magnetic Beads (1|Im)1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione;4-(dipropylsulfamoyl)benzoic acidorb1303318SCHEMBL27467489
데이터베이스 식별자
- CAS
11028-71-0- PubChem CID
- 155486958
- ChEBI
CHEBI:232423- EC Number
- 234-258-2
물성
구조 계산 물성
- 극성 표면적
- 176 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 11
- 회전 가능 결합 수
- 10
- 무거운 원자 수
- 38
- 형식 전하
- 0
- 복잡도
- 858
실험 및 물리화학적 성질
Chemical ClassesOther Uses -> Biochemical Research
Physical DescriptionLyophilized powder; [Sigma-Aldrich MSDS]
물리화학적 성질
- 인화점
- 39 °C · 39 °C
- 저장 조건
- -20 °C · -20°C
- 용해도
- 5 mg/mL, · PBS: 5mg/mL, 약간 흐릿함
- 물리적 상태
- 가루
- 색상
- White to light yellow
- 생물학적 소스
- Canavalia ensiformis (jack bean)
- 수용성
- 물과 인산염 완충 식염수에 약간 용해됩니다.
화학적 성질
Lyophilized
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P203, P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P318, P321, P333+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 7 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Chemical: Concanavalin A
Concanavalin A: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Concanavalin A: Environment tier I assessment
Hazards Summary
Teratogenic effects observed in rabbits (intraperitoneal) and mice (intravenous) exposed during gestation; [Shepard's Catalog of Teratogenic Agents] Causes diffuse hepatitis and changes in thymus and spleen weights in acute intravenous studies of mice; Causes decreased cellular immune response in 30-day intermittent intraperitoneal studies of mice; [RTECS] May cause irritation; May cause skin and respiratory sensitization; May cause toxicity to human reproduction; [Sigma-Aldrich MSDS] PubMed: no results for 11028-71-0 AND (allergic OR sensitizer OR sensitization OR asthma)[Title];
Hazard Classes and CategoriesSkin Sens. 1 (100%)
독성 정보
Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Substances that stimulate mitosis and lymphocyte transformation. They include not only substances associated with LECTINS, but also substances from streptococci (associated with streptolysin S) and from strains of alpha-toxin-producing staphylococci. (Stedman, 25th ed)
용도 및 제조
UsesA plant protein in the lectin family; Isolated from jack beans; Used as a biochemical reagent and as a probe in cell biology (membrane dynamics and cell division); [Merck Index]
응용 분야
용도Concanavalin A is a unique lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis. Concanavalin A specifically binds to α-mannose and α-galactose structures found in sugars, glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures. At 20 mg/kg concanavalin A is also used to induce liver injury in experimental mouse models of autoimmune hepatitis in order to study immune regulation by macrophages and T cells. Concanavalin A is toxic to several tumor cell lines and has been reported to induce programmed cell death of cortical neurons by a mechanism similar to that of the amyloid β peptide.
일반 설명Concanavalin A is a protein containing only β-sheets in its structure, and belongs to the legume lectins family.
추가 설명
정의A lectin mitogen that binds specifically to and agglutinates transforms into tumors. It binds to glucose and mannose residues in the surface.
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