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기본 정보
- CAS
6491-83-4- 표준 SMILES
COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C.Cl- InChIKey
RVXQFTNCULOWRV-ACMTZBLWSA-N- 분자식
- C13H27ClN2O3
- 평균 분자량
- 294.82 g/mol
이름 및 식별자
- 우선 이름
- L-Leucine, L-leucyl-, methyl ester, hydrochloride (1:1)
- IUPAC
- methyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-4-methylpentanoate;hydrochloride
- 영어명
- L-Leucyl-L-Leucine methyl ester (hydrochloride)
- 분자식
- C13H27ClN2O3
- 분자량
- 294.81808
이름 및 동의어
76R0TP2LNWMethyl leucylleucinate hydrochlorideUNII-76R0TP2LNWL-Leucine, L-leucyl-, methyl ester, hydrochloride (1:1)RefChem:2014066491-83-4H-Leu-Leu-Ome.HClH-LEU-LEU-OME HCLH-Leu-leu-OMe hydrochlorideLeu-Leu-ome HClMFCD00155477L-Leucine, L-leucyl-, methyl ester, monohydrochloride
이름 더 보기
L-Leucyl-L-Leucine methyl esterL-Leucyl-L-Leucine methyl ester hydrochloride, 10 mM in DMSOmethyl (2S)-2-[(2S)-2-amino-4-methylpentanamido]-4-methylpentanoate hydrochloridelymphocytes,leukocytes,monocytes,pathway,LLeucylLLeucine methyl ester hydrochloride,LLOMe,inhibit,polymorphonuclear,stress,Leu-Leu methyl ester,cytotoxic,Inhibitor,L Leucyl L Leucine methyl ester hydrochloride,Endogenous Metabolite,endolysosomal
Leu-Leu-ome hydrochlorideL-Leucyl-L-Leucine methyl ester (hydrochloride)methyl L-leucyl-L-leucinate hydrochlorideL-Leucyl-L-leucine Methyl Ester HClLeucylleucine methyl ester hydrochloridemethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-4-methylpentanoate;hydrochlorideC13H27ClN2O3Methyl leucylleucinate HCl
데이터베이스 식별자
- CAS
6491-83-4- PubChem CID
- 15598024
- UNII
- 76R0TP2LNW
물성
구조 계산 물성보충 중
- 극성 표면적
- 81.4 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 8
- 무거운 원자 수
- 19
- 형식 전하
- 0
- 복잡도
- 277
물리화학적 성질
- 녹는점
- 177 · 177-181°C
- 저장 조건
- Hygroscopic, Refrigerator, under inert atmosphere
- 용해도
- DMSO(약간 용해됨), 물(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- 안정성
- 흡습성
화학 및 산업
응용 분야
개요L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.
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