기본 정보
- CAS
861998-00-7- 표준 SMILES
CN(C)N(C)C(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1.Cl- InChIKey
VFYAEUWJFGTGGO-GHTUPXNNSA-N- 분자식
- C31H43ClN6O3
- 평균 분자량
- 583.2 g/mol
- 단동위원소 질량
- 582.3085169
개요
Anamorelin Hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite.
이름 및 식별자
- 우선 이름
- Anamorelin Hydrochloride
- IUPAC
- 2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide;hydrochloride
- 현지명
- 아나모렐린염산염
- 영어명
- AnaMorelin hydrochloride
- 분자식
- C31H43ClN6O3
- 분자량
- 583.16452
이름 및 동의어
Anamorelin hydrochloride861998-00-7Anamorelin HClRC-1291 HCL55F75LJQ0VDTXSID70235443RefChem:558018DTXCID70157934Anamorelin (hydrochloride)Anamorelin hydrochloride [USAN]MFCD23098788RC-1291 hydrochloride;ONO-7643 hydrochloride
이름 더 보기
아나모렐린염산염RC 1291 HClRC 1291 hydrochlorideAlamorim hydrochlorideONO-7643 hydrochlorideAnamorin HydrochlorideAnamorelin (RC-1291) HClAnamorelin MonohydrochlorideAnamorelin (RC-1291) hydrochloride
(3R)-1-((2R)-2-((2-Amino-2-methylpropanoyl)amino)-3-(indol-3-yl)propanoyl)-3-benzyl-N,N',N'-trimethylpiperidine-3-carbohydrazide hydrochloride2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide;hydrochloride3-Piperidinecarboxylic acid, 1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-, trimethylhydrazide, monohydrochloride, (3R)-UNII-55F75LJQ0VAnamorelin?(3R)-1-(2-Methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic Acid Trimethylhydrazide Monohydrochloride; RC 1291 HCl; RC 1291 HydrochlorideAdlumiz (TN)Anamorelin hydrochloride?
물성
구조 계산 물성
- 극성 표면적
- 115 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 9
- 무거운 원자 수
- 41
- 형식 전하
- 0
- 복잡도
- 904
물리화학적 성질
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 28 · DMSO:28.0(Max Conc. mg/mL);48.01(Max Conc. mM)
- 물리적 상태
- 가루
- 색상
- White to off-white
- InChIKey
- VFYAEUWJFGTGGO-LQVXCNOLNA-N
- SMILES
- C(N[C@H](CC1C2=C(NC=1)C=CC=C2)C(N1CCC[C@](CC2=CC=CC=C2)(C(=O)N(N(C)C)C)C1)=O)(=O)C(N)(C)C.[H]Cl |&1:2,18,r|
화학 및 산업
응용 분야
개요Anamorelin Monohydrochloride, also known as ONO-7643, RC-1291, and ST-1291, is a drug developed by Novo Nordisk A/S and later licensed by Helsinn Healthcare SA and Ono Pharmaceutical Co. Anamorelin is used for the treatment of cancer anorexia and cachexia syndrome (CACS), a cancer-related side effect manifested by loss of appetite, weight loss, muscle wasting, and reduced quality of life.
공급사84 곳
无锡恩桥医药科技有限公司+8613812269233 · [email protected]
LIDE PHARMACEUTICALS LIMITED+852-55945652 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
广州佳途科技股份有限公司81960175-877 18933936954 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
湖北海克斯生化有限公司17362916295; 17362916295 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
Aladdin Scientific[email protected]
湖北辰心化工有限公司18696113233 · [email protected]
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