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기본 정보
- CAS
69-27-2- 표준 SMILES
C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1.[I-].[I-]- InChIKey
FPNVAOZHQUJJJQ-UHFFFAOYSA-L- 분자식
- C14H20Cl4I2N2
- 평균 분자량
- 611.948 g/mol
- 단동위원소 질량
- 609.84700536
이름 및 식별자
- 우선 이름
- 4,5,6,7-Tetrachloro-2-methyl-2-[2-(trimethylazaniumyl)ethyl]-2,3-dihydro-1H-isoindol-2-ium diiodide
- IUPAC
- 4,5,6,7-Tetrachloro-2-methyl-2-[2-(trimethylazaniumyl)ethyl]-2,3-dihydro-1H-isoindol-2-ium diiodide
- 영어명
- Chlorisondamine diiodide
- 분자식
- C14Cl4H20I2N2
- 분자량
- 611.94
이름 및 동의어
Chlorisondamine (iodide)CHLORCHLORISONDAMINE DIIODIDEISONDAMINE DIIODIDE4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide
데이터베이스 식별자
- CAS
69-27-2、96750-66-2- PubChem CID
- 16078959
- DTXSID
DTXSID70582020- EC Number
- 692-525-2
물성
물리화학적 성질
- 저장 조건
- 2 · 2-8°C
- 용해도
- 2 O: · H2O: ~3.75 mg/mL
- 물리적 상태
- 고체
- 색상
- 하얀색
- 수용성
- 10 mM · Soluble to 10 mM in water
- InChI
- 1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
- InChIKey
- FPNVAOZHQUJJJQ-UHFFFAOYSA-L
- SMILES
- [I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 2
- ridadr
- UN 3077 9 / PGIII
- risk_code
- 22-50
- hazard_code
- Xn,N
- safety_code
- 60-61
- Hazard Classifications
- Acute Tox. 4 OralAquatic Acute 1
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요Chlorisondamine is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC50 = 1.8 μM in rat striatal synaptosomes) and a ganglion blocker. It decreases dopamine release induced by nicotine (Item Nos. 16535 | 20887) in a dose-dependent manner in rat striatal synaptosomes at concentrations ranging from 0-100 μM. The effect of chlorisondamine is long-lasting, with a 10 mg/kg dose blocking nicotine-induced stimulant activity for at least five weeks. Chlorisondamine (5 μg, i.c.v.) prevents rats from acquiring a (–)-nicotine-induced conditioned taste aversion response, a model of the aversive effects of nicotine. It also inhibits autonomic ganglia, providing approximately 50% inhibition of the contractile response in feline superior cervical ganglion nictitating membrane preparations when administered at a dose of 50 mg/kg.
용도Chlorisondamine diiodide has been used:as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitisas an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) inductionas a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress
공급사17 곳
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
Aladdin Scientific[email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
怀化市冰峰化工有限公司0745-2866851 17711757908 · [email protected]
NANJING YINGWEN BIOTECHNOLOGY CO LTD+8613382787392 · [email protected]
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