4-methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide
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기본 정보
- CAS
870223-96-4- 표준 SMILES
CNc1nccc(-c2cccnc2Oc2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc2C)n1- InChIKey
ZVIWALRWYYSHSU-UHFFFAOYSA-N- 분자식
- C25H20F3N5O2
- 평균 분자량
- 479.5 g/mol
- 단동위원소 질량
- 479.15690938
이름 및 식별자
- 우선 이름
- 4-methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide
- IUPAC
- 4-methyl-3-[[3-[2-(methylamino)pyrimidin-4-yl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide
- 영어명
- 4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide
- 분자식
- C25H20F3N5O2
- 분자량
- 479.45
이름 및 동의어
AMG-Tie2-1870223-96-44-methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamideAMG-Tie 2-14-METHYL-3-[[3-[2-(METHYLAMINO)-4-PYRIMIDINYL]-2-PYRIDINYL]OXY]-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDEAMG-Tie24-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-N-[3-(trifluoromethyl)phenyl]benzamide4-methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(3-(trifluoromethyl)phenyl)benzamide4-methyl-3-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxy-N-[3-(trifluoromethyl)phenyl]benzamideZVIWALRWYYSHSU-UHFFFAOYSA-NMFCD16038641PubChem22413
이름 더 보기
AMG-Tie-2-1,AMGTie21,AMG Tie2 14-Methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)bBenzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-
pyridinyl pyrimidine 15pyridylpyrimidine ether 4AMG-Tie2-1?CHEMBL218632orb1704853SCHEMBL1264498SCHEMBL29433153BDBM14948
데이터베이스 식별자
- CAS
870223-96-4- PubChem CID
- 16108977
- DTXSID
DTXSID20582974- ChEMBL
CHEMBL218632
물성
구조 계산 물성보충 중
- XLogP
- 5.1
- 극성 표면적
- 89 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 9
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 35
- 형식 전하
- 0
- 복잡도
- 697
물리화학적 성질
- 밀도
- 1.357 · 1.357
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 10 mg/mL; · DMF: 10mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL
- 물리적 상태
- 고체
- 색상
- White to off-white
화학 및 산업
응용 분야
개요AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC50 values of 1 and 3 nM, respectively, in a homogenous time-resolved fluorescence (HTRF) assay. It inhibits angiopoietin 1-induced Tie2 autophosphorylation in EA.hy926 human endothelial cells (IC50 = 10 nM).
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