기본 정보
- CAS
52906-92-0- 표준 SMILES
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O- InChIKey
LVRVABPNVHYXRT-BQWXUCBYSA-N- 분자식
- C120H188N34O35S
- 평균 분자량
- 2,699.1 g/mol
- 단동위원소 질량
- 2,697.369705
개요
A peptide of about 22-amino acids isolated from the DUODENUM. At low pH it inhibits gastric motor activity, whereas at high pH it has a stimulating effect.
이름 및 식별자
- 우선 이름
- Motilin
- IUPAC
- (2S)-5-amino-2-[[2-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]acetyl]amino]-5-oxopentanoic acid
- 영어명
- MOTILIN (HUMAN, PORCINE)
- 분자식
- C120H188N34O35S
- 분자량
- 2699.05
이름 및 동의어
MOTILIN52906-92-0RefChem:926155DTXSID301052764Human motilinMotilin (human, porcine)Motilin (porcine)9072-41-7Motilin (human)Motilin (swine)Motilin [MI]Human motilin [MI]
이름 더 보기
Motilin(pig)
UNII-D85V250YSICHEMBL525634D85V250YSIMotilin porcinePhe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-GlnMotilin, human, porcineh-MotilinMotilin, porcine
데이터베이스 식별자
- CAS
52906-92-0、9072-41-7- PubChem CID
- 16136567
- ChEMBL
CHEMBL2372767、CHEMBL525634- Nikkaji
- J506.159H
물성
구조 계산 물성
- XLogP
- -14
- 극성 표면적
- 1,190 Ų
- 수소 결합 공여자 수
- 39
- 수소 결합 수용자 수
- 41
- 회전 가능 결합 수
- 95
- 무거운 원자 수
- 190
- 형식 전하
- 0
- 복잡도
- 6,010
물리화학적 성질
- 밀도
- 1.48 · 1.48±0.1 g/cm3(Predicted)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 25 mg/ml; · DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly; PBS (pH 7.2): 5 mg/ml
- 물리적 상태
- 결정성 고체
화학 및 산업
약리 정보
MeSH Pharmacological ClassificationDrugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
응용 분야
개요Motilin is a polypeptide hormone that stimulates gastric motility through release in the small intestine and into the general circulation during fasting. In isolated rabbit duodenal segments, porcine motilin (10 nM-1 μM) induced phasic contractions and acetylcholine release from enteric neurons (EC50 = 2.5 nM). Formulations containing motilin are used to increase gastrointestinal motility in patients with diabetic gastroparesis, often in combination with erythromycin , an antibiotic and agonist at the motilin receptor.
공급사32 곳
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
南京昱盛康生物科技有限公司13327808530 · [email protected]
上海鸿肽生物科技有限公司15318089928 · [email protected]
杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
Chengdu Youngshe Chemical Co., Ltd.
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