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기본 정보
- CAS
32523-69-6- 표준 SMILES
COc1ccc2c3c(c4cc(OC)c(O)cc4c2c1)CN1CCC[C@H]1[C@H]3O- InChIKey
CMFIDYCYVJWPPL-PGRDOPGGSA-N- 분자식
- C22H23NO4
- 평균 분자량
- 365.429 g/mol
- 단동위원소 질량
- 365.16270822
이름 및 식별자
- 우선 이름
- Tylophorinidine
- IUPAC
- (13aS,14S)-3,7-Dimethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline-6,14-diol
- 현지명
- 틸로포리디신A()
- 영어명
- TYLOPHORIDICINE A(), 98+%
- 분자식
- C22H23NO4
- 분자량
- 365.42
이름 및 동의어
틸로포리디신A()TylophorinidineTYLOPHORIDICINE A(), 98+%(13aS,14S)-3,7-dimethoxy-9,11,12,13,13a,14-hexahydrophenanthro[10,9-f]indolizine-6,14-diol(13aS,14S)-9,11,12,13,13a,14-Hexahydro-3,7-dimethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinoline-6,14-diol(12aS,13S)-3,7-Dimethoxy-6,13-dihydroxy-9,10,11,12,12a,13-hexahydro-9a-aza-9aH-cyclopenta[b]triphenyleneDibenzo[f,h]pyrrolo[1,2-b]isoquinoline-6,14-diol, 9,11,12,13,13a,14-hexahydro-3,7-dimethoxy-, (13aS,14S)-
데이터베이스 식별자
- CAS
32523-69-6- PubChem CID
- 161749
- DTXSID
DTXSID20186239- ChEMBL
CHEMBL250854- Nikkaji
- J17.843H
물성
물리화학적 성질
- 녹는점
- 2 l3-4°C · 2l3-4°C(dec.).
- 끓는 점
- 613.5 · 613.5±55.0 °C(Predicted)
- 밀도
- 1.38 · 1.38±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 9.66 · 9.66±0.40(Predicted)
화학 및 산업
응용 분야
개요The most recently discovered of the Tylophora alkaloids, this base is found in the roots of T. asthmatica and has [α]25D + 108° (c 1.91, MeOH). The ultraviolet spectrum in MeOH has absorption maxima at 258, 286.5, 310, 339.5 and 355 Mu. Two methoxyl groups and two phenolic hydroxyl groups are present and the alkaloid furnishes the O,O-dimethyl ether, m.p. 2l8-2200 C (dec.) and the diacetate, m.p. 192°C.
용도Tylophorinidine is used in biological studies for thymidylate synthase in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia. It allows for inhibition of pergularinine and tylophorinidine (Erratum).
공급사2 곳
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
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