기본 정보
- CAS
62929-91-3- 표준 SMILES
CC[C@@H](NC(C)C)[C@@H](O)c1ccc(O)c2[nH]c(=O)ccc12.Cl- InChIKey
AEQDBKHAAWUCMT-KKJWGQAZSA-N- 분자식
- C16H23ClN2O3
- 평균 분자량
- 326.82 g/mol
- 단동위원소 질량
- 326.1397203
개요
See also: Procaterol (has active moiety).
이름 및 식별자
- 우선 이름
- Procaterol Hydrochloride
- IUPAC
- 8-hydroxy-5-[(1S,2R)-1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one;hydrochloride
- 영어명
- Procaterol hydrochloride
- 분자식
- C16H22N2O3.ClH
- 분자량
- 326.82
이름 및 동의어
procaterol hydrochloride62929-91-34VD1BRT7T8Pro-AirLonterminCI-888CI 888Pro AirHydrochloride, ProcaterolRefChem:176118Procaterol MonohydrochlorideMonohydrochloride, Procaterol
이름 더 보기
PROCATEROL HCLmeptinopc2009EpcalolCateptinAstoprotinCarvedilol-dAficamten Impurity 26Procaterol hydrochlorid
CI888263-763-08-Hydroxy-5-((1S,2R)-1-hydroxy-2-(isopropylamino)butyl)quinolin-2(1H)-one hydrochloridePROCATEROL HYDROCHLORIDE [USAN]EINECS 263-763-0Hydrochloride Procaterol5-(1-Hydroxy-2-isopropylamino)butyl-8-hydroxycarbostyril hydrochlorideUNII-4VD1BRT7T8
데이터베이스 식별자
- CAS
62929-91-3- PubChem CID
- 16219912
- DTXSID
DTXSID901352788- ChEMBL
CHEMBL1322218- UNII
- 4VD1BRT7T8
- EC Number
물성
구조 계산 물성
- 극성 표면적
- 81.6 Ų
- 수소 결합 공여자 수
- 5
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 22
- 형식 전하
- 0
- 복잡도
- 397
물리화학적 성질
- 저장 조건
- 2 · 2-8°C
- 용해도
- 100 mM · Soluble to 100 mM in water and to 100 mM in DMSO
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 7.35 · 7.35 (pKa1)
- 색상
- White to off-white
- 안정성
- 흡습성
- InChI
- 1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m0./s1
- InChIKey
- AEQDBKHAAWUCMT-CVHDTDHSSA-N
- SMILES
- Cl.CC[C@H](NC(C)C)[C@H](O)c1ccc(O)c2NC(=O)C=Cc12
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesRepr. 2 (100%)
안전 데이터
- wgk
- 2
- rtecs
- VC8296000
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS.
응용 분야
개요Procaterol is an agonist of β2-adrenergic receptors (β2-ARs). It binds to (Kd = 46 pM), and is selective for, β2-ARs over β1-ARs (Kd = 4,000 pM). Procaterol binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (; IC50s = 55.1 and 1,660 nM, respectively). It inhibits contractions induced by acetylcholine in isolated guinea pig trachea (EC50 = 10.5 nM). In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 μg/ml.
용도Procaterol Hydrochloride is a short-acting pulmonary β2-agonist for asthma treatment.
일반 설명Procaterol is used to prevent lung fibroblast migration. It has anti-inflammatory properties. It can block type 2 T helper (Th2)-related chemokine production in human monocytes and bronchial epithelial cells.
공급사37 곳
艾吉析科技（上海）有限公司17717235263 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
湖北金梭生物科技有限公司00123456789 · [email protected]
Nantong HI-FUTURE Biology Co., Ltd.
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