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HCID 16422생성일: 2026년 10월 27일

Bromophos

BROMOPHOS-METHYL · Bromofos · s1942 · el400 · Netal · S 1942 · s-1942 · EL 400

https://huagongshe.com/ko/chemical/16422

Bromophos 분자 구조식

식별자 및 물리적 특성

CAS No.2104-96-3
분자식C8H8BrCl2O3PS
평균 분자량366 g/mol
단동위원소 질량363.84922 g/mol
SMILESCOP(=S)(OC)Oc1cc(Cl)c(Br)cc1Cl
InChIKeyNYQDCVLCJXRDSK-UHFFFAOYSA-N
PubChem CID16422
ChEMBLCHEMBL2104572
ChEBICHEBI:82104
EC No.218-277-3
DTXSIDDTXSID1041683

화학 및 물리적 성질

XLogP5.2
극성 표면적59.8
수소 결합 공여자 수0
수소 결합 수용자 수4
회전 가능 결합 수4
무거운 원자 수16
형식 전하0
복잡도276
LogP(분배 계수)log Kow= 5.21
냄새Faint characteristic odor
Color/FormYellow crystals
용해도Sol on most organic solvents such as diethyl etherslightly sol in low molecular weight alcohols.Water solubility: 40 mg/l at 25 °CSoluble in carbon tetrachloride, ether, and toluene.In acetone 1090, dichloromethane 1120, xylene 900, methanol 100 (all in g/l at 20 °C).In water, 0.65 mg/l @ 20 °C
CorrosivityNon-corrosive
끓는 점140-142 °C at 0.01 mm Hgbp0.01 140-142°
녹는점53-54 °C53-56 °C
증기압0.00013 [mmHg]1.3X10-4 mm Hg @ 20 °C
Physical DescriptionYellow solid[Merck Index] Colorless solid[MSDSonline]
Stability/Shelf LifeStable in solution up to pH 9. Slowly hydrolyzed in aqueous alkaline media.This compound is 50% hydrolyzed at pH 13 and 22 °C in 3.5 hours.
Kovats Retention Index198220031990.81985.11996.81984.31985.72008.520262003.61999.21994.41993.320122001.9
Collision Cross Section157.19 Ų [M+H]+157.19 Ų [M+H]+ [CCS Type: TWBuffer gas: N2Ionization: GC-APCI+]
밀도1.704±0.06 g/cm3(Predicted)
인화점>100 °C
저장 조건0-6°C
물리적 상태고체
용해도40mg/L(상온)
BRN1988276
헨리 상수1.0×10-1 mol/(m3Pa) at 25℃, HSDB (2015)
주요 응용농업환경
InChI1S/C8H8BrCl2O3PS/c1-12-15(16,13-2)14-8-4-6(10)5(9)3-7(8)11/h3-4H,1-2H3
InChIKeyNYQDCVLCJXRDSK-UHFFFAOYSA-N
SMILESCOP(=S)(OC)Oc1cc(Cl)c(Br)cc1Cl
NISTBromophos(2104-96-3)
EPABromophos (2104-96-3)

안전 및 규제

GHS 분류WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)
규제 정보2002/2076
유해성 요약Depressed plasma cholinesterase was the only clinical effect found in applicators in a village in AfricaShown to inhibit cholinesterase activity in high-dose feeding and dermal animal studiesEffects in a 100 day high-dose feeding study with rats include slow growth rates and minor degenerative damage to kidneys and liver[HSDB] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]
Special ReportsTafuri J, Roberts JOrganophosphate PoisoningAnn Emerg Med 16 (2): 193-202 (1987)
Hazard Classes and CategoriesAcute Tox. 4 (100%)Aquatic Acute 1 (100%)Aquatic Chronic 1 (100%)Acute toxicity - category 4Hazardous to the aquatic environment (acute) - category 1Hazardous to the aquatic environment (chronic) - category 1Acute Tox. 4 *Aquatic Chronic 1
Standard Transportation Number49 216 74Organophosphorus pesticide, liquid, not otherwise specified (compounds and preparations) (insecticides, other than agricultural, NEC)49 216 75Organophosphorus pesticide, liquid, not otherwise specified (compounds and preparations) (agricultural insecticides, NEC, liquid)
49 105 44
49 105 45
49 216 76
Organophosphorus pesticide, solid, not otherwise specified (compounds and preparations) (insecticides, other than agricultural, NEC)
49 216 77
Organophosphorus pesticide, solid, not otherwise specified (compounds and preparations) (agricultural insecticides, NEC, other than liquid)
Shipment Methods and RegulationsNo person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.
Shipping Name/ Number DOT/UN/NA/IMOUN 2784Organophosphorus pesticide, liquid, flammable, toxic, flash point less than 23 °CUN 3018Organophosphorus pesticide, liquid, toxicUN 3017Organophosphorus pesticide, liquid, toxic flammable, flashpoint between 23 °C and 61 °CIMO 3.2For more Shipping Name/ Number DOT/UN/NA/IMO (Complete) data for BROMOPHOS (6 total), please visit the HSDB record page.
노출 관리 및 개인 보호Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baselineButylcholinesterase activity in serum or plasma = 60% of individual's baselineSample at end of shift[TLVs and BEIs]
처리 방법SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Preventive MeasuresANY MATERIAL SPILLED ON SKIN SHOULD BE IMMEDIATELY REMOVED WITH SOAP & WATER. WHEN SPRAYING & DUSTING...CONTAMINATED CLOTHING SHOULD BE CHANGED FREQUENTLY. /ORGANOPHOSPHORUS PESTICIDES/CONTAINERS ... SHOULD BE CLEANED WITH A SUSPENSION OF BLEACHING POWDER IN WATER OR WITH OTHER ALKALINE SOLN AFTER SOAKING FOR 24 HR AND THEN BE RINSED WITH HOT WATER. /ORGANOPHOSPHORUS PESTICIDES/THE STRICT OBSERVANCE OF HYGIENE RULES- NO SMOKING AND NO FOOD INTAKE DURING WORK, THOROUGH WASHING WITH SOAP AFTER WORK, CHANGING PROTECTIVE CLOTHING BEFORE GOING HOME- IS OF THE UTMOST IMPORTANCE. /ORGANOPHOSPHORUS PESTICIDES/THE PROTECTIVE CLOTHING SHOULD BE KEPT IN SEPARATE PLACES WHERE IT CANNOT BE CONTAMINATED WITH TOXIC CHEMICALS. IT SHOULD BE FORBIDDEN TO KEEP THIS CLOTHING IN LIVING QUARTERS. PROTECTIVE CLOTHING MUST BE WASHED AT LEAST ONCE A WEEK AND EACH TIME IT IS CONTAMINATED WITH PESTICIDES. BEFORE WASHING THE CLOTHING SHOULD BE SOAKED FOR SEVERAL HOURS IN A CALCIUM CARBONATE SOLUTION. /PESTICIDES/
Personal Protective Equipment (PPE)USE OF RUBBER GLOVES, GOGGLES, RESPIRATOR &...PROTECTIVE CLOTHING. /ORGANOPHOSPHORUS PESTICIDES/WORKERS HANDLING AND APPLYING ORGANOPHOSPHORUS PESTICIDES ... MUST BE GIVEN PERSONAL PROTECTIVE EQUIPMENT COMPRISING OVERALLS MADE OF A TIGHT FABRIC OR POLYVINYL CHLORIDE, GLOVES AND RUBBER BOOTS. THEY MUST WEAR A RESPIRATOR WITH AN ACTIVATED-CARBON GAS FILTER CARTRIDGE AFFORDING PROTECTION FOR A DETERMINED NUMBER OF WORKING HOURS. THE EYES SHOULD BE PROTECTED BY GOGGLES. ... /ORGANOPHOSPHORUS PESTICIDES/
상호 작용ANTICHOLINESTERASE (ORGANOPHOSPHORUS) INSECTICIDES ANTAGONIZE POLARIZING MUSCLE RELAXANTS. PHENOTHIAZINES /AND THIOXANTHENES/: ... MAY ENHANCE TOXIC EFFECTS OF ORGANOPHOSPHORUS INSECTICIDES. /INSECTICIDES, ORGANOPHOSPHORUS/A number of phosphorothionate (P = S) insecticides, including bromophos and fenitrothion, prevent trialkyl phosphorothiolate (P = O) induced lung toxicity and the resulting increase in lung weight normally observed at 3 days in the rat. Oxidative metabolism of phosphorothionates known to occur at the P = S moiety, with suicidal loss of p450, may then prevent oxidative activation of an S-methyl on the phosphorothiolates, the most likely site for production of a reactive intermediate capable of damaging the lung. Lung 7- ethoxycoumarin O-deethylase in rat is sensitive to concentrations of the phosphorothionates bromophos and fenitrothion at 5-25 times less than those causing loss of liver 7-ethoxycoumarin O-deethylase activity and at doses 125-600 times less than their LD50s.
생태독성 수치LC50 Guppy 0.5 mg/lLC50 Rainbow trout 0.05-0.5 mg/l
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 16,000(SRC), determined from a log Kow of 5.21(2) and a regression-derived equation(3), indicates that bromophos is expected to be immobile in soil(SRC). Volatilization of bromophos from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.5X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 1.3X10-4 mm Hg(4), and water solubility, 0.65 mg/l(5)however, adsorption may attenuate this process(SRC). Bromophos is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). A first-order rate constant of 0.008 day-1, which corresponds to a half-life of 88.5 days, was reported for a biodegradation screening study utilizing a soil inoculum(6). The half-life of bromophos in soil under illumination by light greater than 290 nm was reported as 48.3 days, while that of a non-illuminated control was 80 days(7), which suggests that photolysis on soil surfaces is possible.AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 16,000(SRC), determined from a log Kow of 5.21(2) and a regression-derived equation(3), indicates that bromophos is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 9.5X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 1.3X10-4 mm Hg(4), and water solubility, 0.65 mg/l(5)however, adsorption may attenuate this process. Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 8 hours and 10 days, respectively if adsorption is neglected(SRC). The estimated volatilization half-life from a model pond is 1.6 years if adsorption is considered(6). Hydrolysis rate constants of 0.00576 day-1 (pH = 5), 0.0127 day-1 (pH = 7), and 0.438 day-1 were reported for bromophos, and correspond to half-lives of 167.5, 54.82 and 1.61 days, respectively(7). Biodegradation is expected to occur slowly based on screening studies in soil and activated sludge(8,9). Photolysis in sunlit surface waters may also be an important fate process for bromophos(SRC). The half-life of bromophos in seawater was 23 days when incubated in the absence of light and 2 days when exposed to natural sunlight at 22 °C (10). According to a classification scheme(11), BCF values of 39,800 and 44,670 measured in guppies(12), suggests bioconcentration in aquatic organisms is very high.ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bromophos, which has a vapor pressure of 1.3X10-4 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase bromophos is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 7 hours(SRC), calculated from its estimated rate constant of 5.9X10-11 cu cm/molecule-sec at 25 °C determined using a structure estimation method(3). The half-life of bromophos in rain water under illumination by light greater than 290 nm was reported as 1.5 days, while that of a non-illuminated control was 5.8 days(4).
식품 조사 수치Bromophos was detected in cabbage and broccoli from Rome, Italy at an average concn of 3.2 ug/kg(1). Bromophos was detected in 2.4% of parsley samples from Belgium at a max concn of 18.8 ppm and a mean concn of 0.194 ppm(2). Bromophos was detected in 1.1% of radish samples from Belgium at a max concn of 0.03 ppm and a mean concn of 0.005 ppm(2). Bromophos was detected in parsley from Belgium at a concn of greater than 5 ppm(3).
유해 작용Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.Other Poison - Organophosphate
Average Daily IntakeThe average daily intake of bromophos in Belgium was reported as 0.04 mg/kg(1).
Medical SurveillanceWorkers handling & applying pesticides must undergo an annual medical examination at the beginning of each agricultural season. /SRP: Protect from exposure those individuals with/ organic diseases of the central nervous system, mental disorders & epilepsy, pronounced endocrine & vegetative disorders, pulmonary tuberculosis, bronchial asthma, chronic respiratory diseases, cardiovascular diseases & circulatory disorders, gastrointestinal diseases (peptic ulcer), gastroenterocolitis, diseases of liver & kidneys, eye diseases (chronic conjunctivitis & keratitis). The blood cholinesterase activity must be determined before work starts. In the event of prolonged work periods, this activity should be determined at intervals of 3-4 days. Persons exhibiting a fall in cholinesterase activity of 25% or more must be transferred to other work where they are not exposed to organophosphorus pesticides until this activity is completely restored. Persons with initial signs of indisposition should cease work with pesticides. /Organophosphorus pesticides/
Soil Adsorption/MobilityThe Koc of bromophos is estimated as 16,000(SRC), using a log Kow of 5.21(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that bromophos is expected to be immobile in soil.
Human Toxicity ExcerptsAll the organophosphorus insecticides have a cumulative effect by progressive inhibition of cholinesterase ... /Organophosphorus insecticides/The symptoms of chronic poisoning due to organophosphorus pesticides include headache, weakness, feeling of heaviness in head, decline of memory, quick onset of fatigue, disturbed sleep, loss of appetite, & loss of orientation. Psychic disorders, nystagmus, trembling of the hands & other nervous system disorders can be observed in certain cases. Sometimes neuritis, paresis & paralysis develop. /Organophosphorus pesticides/Toxic effects may include anorexia, abdominal cramps, nausea, vomiting, diarrhea, incontinence, eye changes, weakness, dyspnea, bronchospasm, lacrimation, increased salivation & sweating, bradycardia, hypotension or hypertension due to asphyxia, cyanosis, & muscular twitching of the eyelids, tongue, face, & neck, possibly progressing to convulsions. Central nervous system symptoms include restlessness, anxiety, dizziness, drowsiness, tremor, ataxia, depression, confusion, & coma. Death may occur from depression of the respiratory or cardiovascular system. Neuropathy appears to be a rare problem with the organophosphorus insecticides now in use. /Organophosphorus insecticides/Organophosphate insecticides ... are potent cholinesterase enzyme inhibitors that act by interfering with the metabolism of acetylcholine, which results in accumulation of acetylcholine at neuroreceptor transmission sites. Exposure produces a broad spectrum of clinical effects indicative of massive overstimulation of the cholinergic system, including muscarinic effects (parasympathetic), nicotinic effects (sympathetic and motor), and CNS effects. These effects present clinically as feeling of headache, weakness, dizziness, blurred vision, psychosis, respiratory difficulty, paralysis, convulsions, and coma. Typical findings are given by the mnemonic "SLUD." which stands for salivation, lacrimation, urination, and defecation. A small percentage of patients may fail to demonstrate miosis, a classic diagnostic hallmark. Onset of clinical manifestation of organophosphate poisoning usually occurs within 12 hours of exposure. /Organophosphate insecticides/For more Human Toxicity Excerpts (Complete) data for BROMOPHOS (13 total), please visit the HSDB record page.
Artificial Pollution SourcesBromophos's former(1) production and use as an insecticide and acaricide(2) resulted in its release to the environment through various waste streams(SRC).
Environmental BiodegradationA first-order rate constant of 0.008 day-1, which corresponds to a half-life of 88.5 days, was reported for a biodegradation screening study utilizing a soil inoculum(1). Bromophos was biodegraded 6.6, 25.7 and 33.1% over 3, 6 and 9 hour incubation periods, respectively with an activated sewage sludge(2).
Environmental BioconcentrationMeasured BCF values of 39,800 and 44,670 ware reported for bromophos in guppies(1). According to a classification scheme(2), this BCF data suggests bioconcentration in aquatic organisms is very high.
수질 위해 등급(WGK)3
RTECS 번호TE7175000
운송 번호(UN)UN3077 9/PG 3
독성LD50 in male, female rats (mg/kg): 1600, 1730 orally (Gaines)
위험 문구(R)22-50/53
위험 표시XnN,N,Xn
안전 문구(S)2-36-60-61-46
위험 등급Acute Tox. 4 OralAquatic Acute 1Aquatic Chronic 1
저장 분류11 - Combustible Solids
유해 물질 데이터2104-96-3(Hazardous Substances Data)