3,3'-Dicarboxybenzidine

Sol in alcohol, ether; insol in water

>40.8 [ug/mL] (The mean of the results at pH 7.4)

3,3'-BENZIDINE DICARBOXYLIC ACID (BDC) SUBCUTANEOUSLY ADMIN TO RATS ONCE A WEEK AT 20 MG FOR 18 MO & TO MICE ONCE A WK AT 5 MG FOR 20.5 MO & WITH FOOD AT 2 MG SIX TIMES WEEKLY HAD A CARCINOGENIC EFFECT, ESP ON THE LIVER OF MICE & ON THE BLOOD FORMING ORGANS, GLANDULAR SECTION OF STOMACH & MAMMARY GLANDS OF RATS. BDC AND ITS SODIUM SALT WERE MUCH LESS CARCINOGENIC THAN BENZIDINE, O-TOLUIDINE BENZIDINE, & 3,3'-DICHLOROBENZIDINE, SUGGESTING THAT THE ABILITY OF AN ORTHO CARBOXYL GROUP TO FORM HYDROGEN BONDS WITH THE AMINO GROUP REDUCES THE FREE RADICAL & BLASTOMOGENIC EFFECTS OF BENZIDINE DERIVATIVES.

Processes in which dried dye is handled have the greatest potential for employee exposure during the manufacture or repackaging of benzidine-based dyes. ... During use of benzidine-based dyes, the greatest potential for exposure would be expected to be among dye-weighers who handle dry powders. /Benzidine-based dyes/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

Used to make copper azo dyes; [HSDB]

Dyestuff

Used for the manufacture of azo dyes containing copper