2,4,5-T Butoxyethyl ester

Extinguish fire using agent suitable for type of surrounding fire. /2,4,5-T amine, ester, or salt/

WATER, FOAM, DRY CHEM, CARBON DIOXIDE. ... WATER OR FOAM MAY CAUSE FROTHING. /2,4,5-T ESTERS/

Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. /2,4,5-T amine, ester, or salt/

Water spill: If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /2,4,5-T amine, ester, or salt/

The following wastewater treatment technology has been investigated for 2,4,5-trichlorophenoxyacetic acid: Concentration process: Biological treatment. /2,4,5-Trichlorophenoxyacetic acid/

Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/

Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/

If material /is not/ involved in a fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. /2,4,5-T amine, ester, or salt/

Keep upwind. ... Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /2,4,5-T amine, ester, or salt/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

8 hr Time Weighted Avg (TWA): 10 mg/cu m. /2,4,5-T/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /2,4,5-T/

A4; Not classifiable as a human carcinogen. /2,4,5-T/

LC50 Lepomis macrochirus (bluegill) 1.4 mg/l/24,48 hr. /Conditions of bioassay not specified/

LC50 Asellus > 3.2 mg/l/96 hr at 15 °C, mature (sample purity: liq 58.3%). Static bioassay without aeration, pH 7.2-7.5, water hardness 225 ppm as calcium carbonate.

LC50 Gammarus fasciatus (scud), 0.12 mg/l/96 hr at 15 °C, mature (sample purity: liq 58.3%). Static bioassay without aeration, pH 7.2-7.5, water hardness 40-50 mg/l as calcium carbonate and alkalinity of 30-35 mg/l.

LC50 Palaemonetes (shrimp), 2.7 mg/l/96 hr at 21 °C, mature, (sample purity: liq 58.3%). Static bioassay without aeration, pH 7.2-7.5, water hardness 272 ppm as calcium carbonate.

For more Ecotoxicity Values (Complete) data for 2,4,5-T BUTOXYETHANOL ESTER (11 total), please visit the HSDB record page.

2,4,5-T ESTERS ARE RAPIDLY HYDROLYZED AFTER SPRAYING, & THE 2,4,5-T IS THEN FURTHER DECOMPOSED BY BACTERIAL ACTION. THE MAJOR PRODUCT OF 2,4,5-T PHOTODECOMPOSITION IS 2,4,5-TRICHLOROPHENOL. OTHER PRODUCTS IDENTIFIED INCLUDED 4,6-DICHLORORESORCINOL, 4-CHLORORESORCINOL, 2,4,5-TRICHLOROANISOLE. /2,4,5-T/

TERRESTRIAL FATE: 2,4,5-T butoxyethanol ester will be susceptible to aqueous hydrolysis, particularly in moist alkaline soils; aqueous hydrolysis half-lives of 210 hr (pH 7), 21 hr (pH 8) and 2.1 hr (pH 9) have been estimated for 2,4,5-T butoxyethanol ester(1,SRC). As soil increases in acidity, hydrolysis will become increasingly less important. Estimated Koc values of 600-130000(2-3,SRC) suggest that soil mobility will range from low to immobile(4); therefore, leaching may not be important(SRC). Insufficient data are available to predict the relative importance of biodegradation in soil(SRC).

AQUATIC FATE: 2,4,5-T butoxyethanol ester is susceptible to aqueous hydrolysis, particularly in alkaline waters; aqueous hydrolysis half-lives of 210 hr (pH 7), 21 hr (pH 8) and 2.1 hr (pH 9) have been estimated for 2,4,5-T butoxyethanol ester(1,SRC). As waters increase in acidity, hydrolysis will become increasingly less important. Estimated Koc values of 600-130000 suggest that partitioning from the water column to sediment and suspended material may be important(2-3,SRC). Bioconcentration in aquatic organisms may also be important based upon an estimated BCF value of 6500(2,SRC). Insufficient data are available to predict the relative importance of biodegradation. Aquatic volatilization and photolysis are not expected to be important(SRC).

ATMOSPHERIC FATE: Based upon an extrapolated (from a measured range at 72-182 °C) vapor pressure of 1.5X10-6 mm Hg at 25 °C(1), 2,4,5-T butoxyethanol ester can exist in both the vapor and particulate-phases in the ambient atmosphere(2,SRC). It will degrade rapidly in the vapor-phase by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 17 hr(3,SRC). Physical removal of particulates by dry deposition (settling) and wet deposition (rainfall, washout) will also occur(SRC).

Because dermal absorption is an important route of exposure to chlorophenoxy herbicides, biological monitoring is useful in estimating the absorbed dose. Urine concn provide the most accurate estimate of body burden; because of slow absorption, it is best to collect samples after a few days of exposure. /Chlorophenoxy herbicides/

Based upon an estimated log Kow of 5.32(1), the Koc for 2,4,5-T butoxyethanol ester can be estimated to range from 19000-130000 from applicable regression-derived equation(2,SRC). According to a suggested classification scheme(3), these estimated Koc values suggest that 2,4,5-T butoxyethanol ester is generally immobile in soil(SRC). Using a structure estimation method based on molecular connectivity indexes, the Koc for 2,4,5-T butoxyethanol ester can be estimated to be about 600(4,SRC) which is indicative of low soil mobility(3,SRC).

During mixing & spraying operations along power line right-of-way, airborne concn of 2,4,5-T esters were < 10-60 ug/cu m. /Chlorophenoxy herbicides/

As part of the USEPA's National Pesticides Monitoring Programs, the EPA Air Monitoring Network collected ambient air samples at 45 sites in 29 localities throughout the continental US during 1970-1972(1,2); sampling locations were selected for their potentially high concns of pesticides such as agricultural or urban sites(1); in 1970, 2,4,5-T butoxyethanol ester was detected in 0.51% of all samples from 14 states with an arithmetic mean, mean of positive samples and maximum concn of 0.1, 20.3 and 43.0 ng/cu m, respectively(1); in 1971, 2,4,5-T butoxyethanol ester was detected in 1.22% of all samples from 16 states with an arithmetic mean, mean of positive samples and maximum concn of 0.3, 15.8 and 27.4 ng/cu m, respectively(1); it was not detected (specific detection limit not reported, but in range of 1-10 ng/cu m) during 1972 monitoring in 16 states(1).

The chlorophenoxy herbicides have produced contact dermatitis in man ... . /Chlorophenoxy compounds/

Phenoxyherbicides including (2,4,5-trichlorophenoxy)acetic acid have been widely used in New Zealand for over 30 years. In the light of Swedish studies reporting an association between exposure to phenoxyherbicides or chlorophenols and soft tissue sarcoma, a case-control study was undertaken that involved interviewing 82 subjects (cases) with soft tissue sarcoma and 92 controls with other types of cancer. For those potentially exposed to phenoxyherbicides for more than 1 day not in the 5 years before cancer registration, the estimate of relative risk was 1.3, with 90% confidence limits of 0.6-2.5. The comparable relative risk estimate for chlorophenol exposure was 1.5, with 90% confidence limits of 0.5-4.5. The discovery of cases in trichlorophenol manufacturing plants in the United States lended support to the Swedish findings but further studies are needed to conclude whether human exposure to these chemicals truly increases the risk of soft tissue sarcoma. /Phenoxyherbicides/

A previous case control study which used occupational information available on agricultural workers found an increased risk of developing non-Hodgkin's lymphoma. The findings are now presented for the second phase of the study which entailed interviewing 83 cases of non-Hodgkin's lymphoma registered under code 202 of the International Classification of Diseases together with 168 controls with other types of cancer and 228 general population controls. The findings for the two control groups were similar, and there were no significant differences between cases and controls regarding potential exposure to phenoxyherbicides (odds ratio= 1.4, 90% confidence limits 0.7-2.5, p= 0.26) or chlorophenols (odds ratio= 1.3, 90% confidence limits 0.6-2.7, p= 0.39). The odds ratio for fencing work, necessitating exposure to several potential risk factors including arsenic and sodium pentachlorophenate was 2.0 (90% confidence limits 1.3-3.0, p= 0.01). The odds ratio for employment in a meat works, necessitating potential exposure to 2,4,6-trichlorophenol and zoonotic viruses, was 1.8 (90% confidence limits 1.1-3.1, p= 0.04). There was a significant statistical interaction between the risks associated with these two activities, the odds ratio for involvement in both activities compared with involvement in neither being 5.7 (90% confidence limits 2.3, p= 0.03). /Phenoxyherbicides, chlorophenols, arsenic, and sodium pentachlorophenate/

Generally low systemic toxicity, may contain dioxins as contaminants, which have caused chloracne and neurologic damage to chemical plant workers; causes headache, dizziness. /Chlorophenoxy compounds; from table/

For more Human Toxicity Excerpts (Complete) data for 2,4,5-T BUTOXYETHANOL ESTER (6 total), please visit the HSDB record page.

2,4,5-T butoxyethanol ester has been detected in ambient air samples collected in the vicinity of agricultural pesticide spraying and applications(1); 2,4,5-T butoxyethanol ester's use as a herbicide releases the compound directly to the environment(SRC).

Based upon an estimated log Kow of 5.32(1), the BCF for 2,4,5-T butoxyethanol ester can be estimated to be 6500 from a recommended regression-derived equation(2,SRC). This estimated BCF value suggests that bioconcentration in aquatic organisms may be environmentally important(SRC).

The Henry's Law constant for 2,4,5-T butoxyethanol ester can be estimated to be 7.95X10-8 atm-cu m/mole using a structure estimation method(1,SRC). This value of Henry's Law constant indicates that a compound is essentially non-volatile from water(2).

The herbicides 2,4,5-T and 2,4-D induced fetopathy and an increased incidence of skeletal anomalies following single daily oral doses of 100-150 mg/kg to pregnant rats on days 6-15 of gestation. Similar teratogenic effects were detected in trials with butyl, isooctyl, butoxyethanol, and dimethylamine derivatives. The observed skeletal defects were not incompatible with postnatal survival, weight gain and viability of the offspring from treated dams being within control limits. Thus, the postnatal parameters examined appeared to be unrelated to the teratologic potential of these chemicals.

Ten chicks of both sexes were fed 0-100 mg/kg (acid equivalent) for 21 days, no effect was observed. At 1000 mg/kg (acid equivalent) for 21 days, reduced growth rate, and food consumption was observed. At 5000 mg/kg (acid equivalent) for 21 days, 90% mortality was observed. At 7500 mg/kg (acid equivalent) for 14 days, 100% mortality was observed. /From table/

Japanese quail (n= 15) of /both sexes were/ fed 5000 mg/kg of 2,4,5-T butoxyethanol ester for 5 days. No mortality /was observed/. Pheasants (n= 10) of /both sexes were/ fed 3950 mg/kg of 2,4,5-T butoxyethanol ester for 5 days. 50% mortality /was observed/. Mallards (n= 10) of /both sexes were/ fed 5000 mg/kg of 2,4,5-butoxyethanol ester for 5 days. 10% mortality /was observed/. /From table, acid equivalent not specified/

Concern about the toxicology of 2,4,5-T & related compounds centers primarily on teratogenic action in exptl animals. The 1st studies to reveal this action were ... conducted with a sample of 2,4,5-T that contained a high level (about 30 ppm) of contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin. This contaminant is formed during synthesis of the trichlorophenol precursor. /Chlorophenoxy compounds/

For more Non-Human Toxicity Excerpts (Complete) data for 2,4,5-T BUTOXYETHANOL ESTER (6 total), please visit the HSDB record page.

F027; As stated in 40 CFR 261.31, discarded unused formulations containing tri-, tetra-, or pentachlorophenol or discarded unused formulation containing compounds derived from these chlorophenols. (This listing does not include formulations containing hexachlorophene synthesized from prepurified 2,4,5-trichlorophenol as the sole component.). /2,4,5-T/

Criteria of concern: Oncogenicity, mutagenicity, and fetotoxicity. Action/Use Affected: Cancelled, all products. Reference: 44 FR 15917 (3/15/79); 44 FR 41536 (7/17/79); 48 FR 48434 (10/18/83). Ruling by an Administrative Law Judge, January 2, 1985. /2,4,5-T cmpd/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). /2,4,5-T Esters/

2,4,5-T Esters are designated as a hazardous substances under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. /2,4,5-T Esters/