메틸-(4-니트로페녹시)-페녹시-술파닐리덴-포스포란

(Non-Specific -- Organophosphorus Pesticide) Stay upwind; keep out of low areas. Move containers from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. Do not extinquish fire unless flow can be stopped; or extinguish fire using agent suitable for type surrounding fire. Use water in flooding quantities as fog; solid streams of water may be ineffective; cool all affected containers with flooding quantities of water; apply water from as far a distance as posible; Use alcohol foam, carbon dioxide, or dry chemical. /Organphosphorus pesticide, liq, NOS (cmpd & prepn) (insecticides, other than agricultural, NEC); Organophosphorus pesticide, liq, NOS (cmpd & prepn) (agricultural insecticides, NEC, liq); Organophosphorus pesticide, solid, NOS (cmpd & prepn) (insecticides, other than agricultural, NEC); Organophosphorus pesticide, solid, NOS (cmpd & prepn) (agricultural insecticides, NEC, other than liq)/

Rooms used for storage only should be soundly constructed & fitted with secure locks. Floors should be kept clear & pesticides clearly identified. If repacking is carried out in storage rooms, adequate light should be available; floors should be impervious & sound ... . /Pesticides/

Pesticides containers must be provided with labels indicating the degree of toxicity of the product they contain. The labels must not only give a short description of how to use the prepn, but also state basis precautions to be taken when applying it. /Organophosphorus pesticides/

Pesticides of any degree of toxicity should be transported in containers which are clearly labelled, leak-proof, and not easily damaged. They should never be transported beside, or above any type of food, and all spillages should be immediately reported. /Pesticides/

Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Organophosphorus pesticide, solid, not otherwise specified, (compounds and preparations) (agricultural insecticides, not elsewhere classified, other than liquid); organophosphorus pesticides, solid, not otherwise specified (cmpd & prepn) (insecticides, other than agricultural, not elsewhere classified)/

In case of damage to, or leaking from containers of this material, contact the Pesticide Safety Team Network at (800) 424-9300. /Organophosphorus pesticide, solid not otherwise specified, (cmpd & prepn) (insecticide, other than agricultural, not elsewhere classified); Organophosphorus pesticide, liq, not otherwise specified (cmpd & prepn) (agricultural insecticides, not elsewhere classified, liq), (insecticides, other than agricultural, not otherwise classified), and (agricultural insecticides, not elsewhere classified, liq); Organophosphorus pesticide, solid, not otherwise specified (cmpd & prepn) (insecticides, other than agricultural, not elsewhere classified); and (agricultural insecticides, not elsewhere classified, other than liq)/

The protective clothing should be kept in separate places where it cannot be contaminated with toxic chemicals. It should be forbidden to keep this clothing in living quarters. Protective clothing must be washed when it is contaminated with pesticides. Before washing the clothing should be soaked for several hours in a calcium carbonate solution. /Organophosphorus pesticides/

In some situations where personnel may become accidently contaminated ... it is necessary to provide shower bath in addition to the usual washing facilities. Special arrangements for cleaning clothing & overalls may be necessary ... /Pesticides/

For more Preventive Measures (Complete) data for PHOSPHONOTHIOIC ACID, METHYL-, O-(4-NITROPHENYL) O-PHENYL ESTER (9 total), please visit the HSDB record page.

0.024 [mg/m3]

0.26 [mg/m3]

1.6 [mg/m3]

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/

WORKERS HANDLING AND APPLYING ORGANOPHOSPHATE PESTICIDES (OPP) MUST ... BE GIVEN PERSONAL PROTECTIVE EQUIPMENT COMPRISING OVERALLS MADE OF A TIGHT FABRIC OR POLYVINYL CHLORIDE, GLOVES, AND RUBBER BOOTS. THEY MUST WEAR A RESPIRATOR WITH AN ACTIVATED-CARBON GAS FILTER CARTRIDGE AFFORDING PROTECTION FOR A DETERMINED NUMBER OF WORKING HOURS. THE EYES SHOULD BE PROTECTED BY GOGGLES. THE SIGNALMEN FOR AERIAL DUSTING OPERATIONS SHOULD BE EQUIPPED WITH A HAT AND CAPE MADE OF POLYVINYL CHLORIDE OR A FABRIC IMPREGNATED WITH A WATER REPELLENT. /PESTICIDES, ORGANOPHOSPHORUS/

Wear appropriate chemical protective gloves, boots & goggles. /Organophosphorus pesticide, solid, not otherwise specified, (cmpd & prepn) (insecticide, other than agricultural, not elsewhere classified)and (agricultural insecticides, not elsewhere classified, other than liq) ; Organophosphorus pesticide, liq, not otherwise specified (cmpd & prepn) (insecticides, other than agricultural, not elsewhere classified), and (agricultural insecticides, not elsewhere classified, liq)/

Wear appropriate chemical protective clothing. /Organophosphorus pesticide, liq, not otherwise specified, (cmpd & prepn) (insecticide, other than agricultural, not elsewhere classified); organophosphorus pesticide, (cmpd & prepn) (agricultural insecticides, not elsewhere classified), liq)/

If contact with the material anticipated, wear appropriate chemical protective clothing. /Organophosphorus pesticide, solid, not otherwise specified, (compounds and preparations) (agricultural insecticides, not elsewhere classified, other than liquid); organophosphorus pesticides, solid, not otherwise specified (cmpd & prepn) (insecticides, other than agricultural, not elsewhere classified)/

Workers handling & applying pesticides must undergo an annual medical examination at the beginning of each agricultural season. Contraindications for work with /organophosphorus pesticides/ are organic diseases of the central nervous system, mental disorders & epilepsy, pronounced endocrine & vegetative disorders, pulmonary tuberculosis, bronchial asthma, chronic respiratory diseases, cardiovascular diseases & circulatory disorders, gastrointestinal diseases (peptic ulcer), gastroenterocolitis, diseases of liver & kidneys, eye diseases (chronic conjunctivitis & keratitis). The blood cholinesterase activity must be determined before work starts. In the event of prolonged work periods, this activity should be determined at intervals of 3-4 days. Persons exhibiting a fall in cholinesterase activity of 25% or more must be transferred to other work where they are not exposed to organophosphorus pesticides until this activity is completely restored. Persons with initial signs of indisposition should cease work with pesticides. /Organophosphorus pesticides/

A final diagnosis of mild to moderate acute organophosphate pesticide poisoning is rarely justified unless all of the following five conditions are present: 1. A definite history of exposure to an organophosphate pesticide. 2. A latent interval of not more than a few hours between that last exposure and the onset of illness. 3. A clinical picture in which most or all of the following signs or symptoms are present: headache, blurred vision, weakness, tightness in chest, and constricted pupils. 4. Reduction of plasma and RBC cholinesterase activity to a level substantially below 50% of baseline values. Because of the wide normal range of RBC cholinesterase in the population, symptoms may be present with reported "normal" levels. 5. An acute illness that is not substantially longer than 48 hours. The classic presentation for acute organophosphate toxicity includes history, evidence of exposure to organophosphate (garlic odor), signs/symptoms of cholinergic excess, improvement with atropine or pralidoxime, and inhibition of cholinesterase in blood. /Organophosphate pesticide poisoning/

All the organophosphorus insecticides have a cumulative effect by progressive inhibition of cholinesterase ... /Organophosphorus insecticides/

The symptoms of chronic poisoning due to organophosphorus pesticides include headache, weakness, feeling of heaviness in head, decline of memory, quick onset of fatigue, disturbed sleep, loss of appetite, & loss of orientation. Psychic disorders, nystagmus, trembling of the hands & other nervous system disorders can be observed in certain cases. Sometimes neuritis, paresis & paralysis develop. /Organophosphorus pesticides/

Organophosphorus cmpd can produce dermal irritation but most are weak sensitizers. /Organophosphate cmpd/

Toxic effects may include anorexia, abdominal cramps, nausea, vomiting, diarrhea, incontinence, eye changes, weakness, dyspnea, bronchospasm, lacrimation, increased salivation & sweating, bradycardia, hypotension or hypertension due to asphyxia, cyanosis, & muscular twitching of the eyelids, tongue, face, & neck, possibly progressing to convulsions. Central nervous system symptoms include restlessness, anxiety, dizziness, drowsiness, tremor, ataxia, depression, confusion, & coma. Death may occur from depression of the respiratory or cardiovascular system. Neuropathy appears to be a rare problem with the organophosphorus insecticides now in use. /Organophosphorus insecticides/

For more Human Toxicity Excerpts (Complete) data for PHOSPHONOTHIOIC ACID, METHYL-, O-(4-NITROPHENYL) O-PHENYL ESTER (8 total), please visit the HSDB record page.

The signs of poisoning due to organophosphorus cmpd are those due to accumulation of acetylcholine & hence overstimulation of parasympathetic nervous system. It is usual to divide them under 3 headings: muscarinic, nicotinic & central. Muscarinic signs ... consist of hypersalivation, lacrimation, sweating & nasal discharge. Miosis, dyspnea, vomiting, diarrhea & frequency of urination ... Nicotinic effects consist of fasciculation of muscles, weakness & paralysis. Central nervous system effects include nervousness, apprehension, ataxia, convulsions & coma. Death is due to resp failure, or sometimes cardiac arrest. There is little difference between signs produced by different organophosphorus compounds, but route of absorption may influence one system more than another. /Organophosphorus cmpd/

In adult cattle the minimum toxic oral dose of organophosphate pesticides varies from 1 to 125 mg/kg; the minimum toxic dermal concentration varies from 0.5 to 3%, but these figures are not sacred. The literature is not complete with regard to animal toxicity of organophosphates; even if it were, toxicity values would not be reliable because of the number of factors that influence toxicity of these chemicals under different conditions of use. These factors, not actual numbers, warrant discussion. /Organophosphorus pesticides/

Biologic factors also influence toxicity of organophosphates. Species is very important here. ... Age of the animal is another biologic factor that alters toxicity of organophosphate pesticides. Compounds that do not require enzymatic activation are more toxic in very young animals in which the enzymes of pesticide degradation are deficient. Compounds that require enzymatic activation are not so toxic for very young animals because the enzymes of activation are deficient during the early weeks of life. Sex of the animals can also alter toxicity of organophosphates ... . /Organophosphate pesticides/

1. ESTABLISH CLEAR AIRWAY BY ASPIRATION OF SECRETIONS. ADMIN OXYGEN BY MECHANICALLY ASSISTED PULMONARY VENTILATION. IMPROVE TISSUE OXYGENATION AS MUCH AS POSSIBLE BEFORE ADMIN ATROPINE TO MINIMIZE RISK OF VENTRICULAR FIBRILLATION. 2. ADMIN ATROPINE SULFATE IV, OR IM IF IV INJECTION IS NOT POSSIBLE. ... IN MODERATELY SEVERE POISONING: ADULT DOSAGE, INCL CHILDREN OVER 12 YR: 0.4-2.0 MG REPEATED EVERY 15-30 MIN UNTIL ATROPINIZATION ... ACHIEVED: TACHYCARDIA (PULSE OF 140/MIN), FLUSHING, DRY MOUTH, DILATED PUPILS). MAINTAIN ATROPINIZATION BY REPEATED DOSES FOR 2-12 HR OR LONGER DEPENDING ON SEVERITY OF POISONING. /ORGANOPHOSPHATE PESTICIDES/

2. IN MODERATELY SEVERE POISONING: DOSAGE /OF ATROPINE/ FOR CHILDREN UNDER 12 YR: 0.05 MG/KG BODY WT REPEATED EVERY 15 MIN UNTIL ATROPINIZATION IS ACHIEVED. MAINTAIN ATROPINIZATION WITH REPEATED DOSAGE OF 0.02-0.05 MG/KG. SEVERELY POISONED INDIVIDUALS MAY EXHIBIT ... TOLERANCE TO ATROPINE; TWO OR MORE TIMES THE DOSAGES SUGGESTED ABOVE MAY BE NEEDED. PERSONS NOT POISONED OR ONLY SLIGHTLY POISONED, HOWEVER, MAY DEVELOP SIGNS OF ATROPINE TOXICITY FROM SUCH LARGE DOSAGES: FEVER, MUSCLE FIBRILLATIONS, & DELIRIUM ... IF THESE SIGNS APPEAR PATIENT IS FULLY ATROPINIZED, ATROPINE ADMIN SHOULD BE DISCONTINUED, AT LEAST TEMPORARILY. /ORGANOPHOSPHATE PESTICIDES/

3. DRAW BLOOD SAMPLE FOR PLASMA & RBC CHOLINESTERASE ANALYSIS. 4. ADMIN PRALIDOXIME (PROTOPAM-AYERST, 2-PAM) IN CASES OF SEVERE POISONING ... IN WHICH RESP DEPRESSION, MUSCLE WEAKNESS & TWITCHINGS ARE SEVERE. ... ADULT DOSAGE (INCL CHILDREN OVER 12): GIVE 1.0 G IV @ NO MORE THAN 0.5 G/MIN. CHILD'S DOSE (UNDER 12 YR): GIVE 20-30 MG/KG (DEPENDING ON SEVERITY) IV, INJECTING NO MORE THAN HALF TOTAL DOSE/MIN. DOSAGE ... MAY BE REPEATED IN 1-2 HR, THEN @ 10-12 HR INTERVAL IF NEEDED. IN VERY SEVERE POISONINGS, DOSAGE ... MAY BE DOUBLED. /ORGANOPHOSPHATE PESTICIDES/

4. CAUTION: BE PREPD TO ASSIST PULMONARY VENTILATION IF RESP ... DEPRESSED ... 5. OBSERVE PATIENT CLOSELY ... @ LEAST 24 HR TO INSURE THAT SYMPTOMS (SWEATING, VISUAL DISTURBANCES, VOMITING, DIARRHEA, CHEST & ABDOMINAL DISTRESS & SOMETIMES PULMONARY EDEMA) DO NOT OCCUR AS ATROPINIZATION WEARS OFF. IN VERY SEVERE POISONINGS BY ... /INGESTION/ METABOLIC DISPOSITION OF TOXICANT MAY REQUIRE AS MANY AS 5-10 DAYS, DURING WHICH ATROPINIZATION MUST BE MAINTAINED. ... 6. BATHE & SHAMPOO ... WITH SOAP & WATER IF THERE IS ANY CHANCE THAT SKIN & HAIR...CONTAMINATED. 7. IF ... INGESTED /& POISONING OCCURS/ ... EMPTY STOMACH & INTESTINE. A. IF VICTIM ... ALERT & RESP ... NOT DEPRESSED, GIVE SYRUP OF IPECAC ... TO INDUCE VOMITING: ADULT (12 YR & OVER): 30 ML; CHILDREN UNDER 12 YR: 15 ML. /ORGANOPHOSPHATE PESTICIDES/

For more Antidote and Emergency Treatment (Complete) data for PHOSPHONOTHIOIC ACID, METHYL-, O-(4-NITROPHENYL) O-PHENYL ESTER (9 total), please visit the HSDB record page.

Used as broad spectrum insecticide; Has not been marketed; [HSDB]

Farming (Pesticides) [Category: Industry]

Broad spectrum insecticide (Product has not been marketed)