Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N- 에틸 -2- 피 롤리 돈
1-에틸-2-피롤리딘온 · 1-에틸-2-피롤리디논 · 에틸(1-)-2-피롤요돈 · 2-피롤리딘온,1-에틸- · 에틸피롤리돈 · 1-에틸-2-피롤리디논(1-ETHYL-2-PYRROLIDINONE) · N- 에틸 -2- 피 롤리 돈 · 1-에틸-2-피롤리돈
식별자 및 물리적 특성
| CAS No. | 2687-91-4 |
|---|---|
| 분자식 | C6H11NO |
| 평균 분자량 | 113.16 g/mol |
| 단동위원소 질량 | 113.08406397 g/mol |
| SMILES | CCN1CCCC1=O |
| InChIKey | ZFPGARUNNKGOBB-UHFFFAOYSA-N |
| PubChem CID | 17595 |
| ChEMBL | CHEMBL12221 |
| ChEBI | CHEBI:173690 |
| EC No. | 220-250-6 |
| DTXSID | DTXSID3044413 |
| 현지명 | N- 에틸 -2- 피 롤리 돈 |
화학 및 물리적 성질
| XLogP | -0.1 |
|---|---|
| 극성 표면적 | 20.3 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 1 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 8 |
| 형식 전하 | 0 |
| 복잡도 | 101 |
| 증기압 | 0.1 [mmHg]18Pa at 20℃ |
| Physical Description | LiquidCBIClear colorless to light yellow liquid with an amine odor[ECHA - Proposal for Harmonised Classification and Labelling] Colorless liquid[Taminco MSDS] |
| Kovats Retention Index | 1856 |
| Collision Cross Section | 121.7 Ų [M+H]+ [CCS Type: DTBuffer gas: N2Ionization: APCI+Dataset: TOXCASTSource Identifier: DTXSID3044413] |
| 녹는점 | 87.5-88.5 °C |
| 끓는 점 | 97 °C/20 mmHg (lit.) |
| 밀도 | 0.992 g/mL at 25 °C (lit.) |
| 굴절률 | n20/D 1.465(lit.) |
| 인화점 | 169 °F |
| 저장 조건 | Sealed in dry,Room Temperature |
| pKa(산도 계수) | -0.41±0.20(Predicted) |
| 물리적 상태 | 액체 |
| 색상 | 투명한 |
| pH | 8-9 (100g/l, H2O, 20℃) |
| 폭발한계 | 1.3-7.7%(V) |
| 생물학적 소스 | rabbit |
| 용해도 | 1000g/L at 23℃ |
| BRN | 107971 |
| Specific Activity | 4.25-5.75nmol/min·mg |
| 화장품 원료 기능 | 용제 |
| InChI | 1S/C6H11NO/c1-2-7-5-3-4-6(7)8/h2-5H2,1H3 |
| InChIKey | ZFPGARUNNKGOBB-UHFFFAOYSA-N |
| SMILES | CCN1CCCC1=O |
| LogP(분배 계수) | -0.2 at 20℃ |
| 표면장력 | 36.5mN/m at 293.15K |
| NIST | 1-Ethyl-2-pyrrolidinone(2687-91-4) |
| EPA | 2-Pyrrolidinone, 1-ethyl- (2687-91-4) |
화학적 성질
N-Ethyl-2-pyrrolidone (NEP) is a colorless, clear liquid that serves as a low-volatility aprotic solvent classified as a reproductive toxicant. It is characterized by high solvency, low vapor pressure, and a low dielectric constant.
안전 및 규제
| GHS 분류 | DangerH360D: May damage the unborn child [Danger Reproductive toxicity]P203, P280, P318, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 5.9% (90 of 1525) of reports. |
|---|---|
| 규제 정보 | Hazard Traits - Reproductive ToxicityAuthoritative List - EC Annex VI CMRs - Cat. 1BReport - if used as a fragrance or flavor ingredient2-Pyrrolidinone, 1-ethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Pyrrolidinone, 1-ethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)SP - indicates a substance that is identified in a proposed Significant New Use Rule.Status: Active Update: 16-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13618Restricted substance: 1-ethylpyrrolidin-2-one (NEP)EC: 220-250-6Restriction condition document: PDF link1-ethyl-2-Pyrrolidinone: Does not have an individual approval but may be used under an appropriate group standard |
| 유해성 요약 | N-Ethyl-2-pyrrolidone (NEP) is a low volatility aprotic solvent classified as a reproductive toxicant. [ACGIH] An irritant that may cause serious eye injurySuspected of being toxic the developing child[ECHA REACH Registrations] Mild developmental toxicity observed in dermal study of rats in the presence of maternal toxicityDevelopmental toxicity (in 1 of the 2 studies) and teratogenicity (both studies) observed in rabbits at oral doses producing marked maternal toxicity[EPA - TSCATS] A skin and moderate eye irritantAnimal studies have demonstrated corrosive injuries to eyes, no skin irritation, no sensitization, the liver and kidney as target organs of toxicity, no mutagenic or carcinogenic effects, and reproductive toxicity[Taminco MSDS] See N-Methyl-2-pyrrolidone. |
| Hazard Classes and Categories | Acute Tox. 4 (28.7%)Skin Irrit. 2 (11.9%)Eye Dam. 1 (62.2%)Eye Irrit. 2 (23.7%)STOT SE 3 (11.9%) |
용도
용도
피 롤리 돈 계열 제품 생산에 사용되며 유질 정제, 화약, 코팅, 염료, 내열성 거대 분자량 중합 수지, 고무 탈지, 빛이 안티 에칭 시약은 약제를 벗겨 내고 시약은 의약품, 에폭시, 아세틸렌, 피 프로 릴렌 추출물, 천연 가스 탈황, 합성 섬유 방사 매체, 안료 분산기 등을 발사합니다.
용도
1-Ethyl-2-pyrrolidone was used to modify coir fiber (from Cocos nucifera) by photocuring.
일반 설명
1-Ethyl-2-pyrrolidone is a transdermal absorption-enhancing compound and mechanism of its effect on multilammellar liposome of stratum corneum lipid has been studied.