기본 정보
- CAS
106017-08-7- 표준 SMILES
CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2SCC4)CC1.Cl- InChIKey
LPQOADBMXVRBNX-UHFFFAOYSA-N- 분자식
- C17H19ClFN3O3S
- 평균 분자량
- 399.9 g/mol
- 단동위원소 질량
- 399.0819685
이름 및 식별자
- 우선 이름
- 7H-Pyrido(1,2,3-de)-1,4-benzothiazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrochloride (1:1)
- IUPAC
- 7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;hydrochloride
- 영어명
- Rufloxacin hydrochloride
- 분자식
- C17H19ClFN3O3S
- 분자량
- 399.87
이름 및 동의어
RUFLOXACIN HYDROCHLORIDE106017-08-7MF-934QariDTXSID00457091643374N6LDTXCID8025709RefChem:883971rufloxacin monohydrochloride7H-Pyrido(1,2,3-de)-1,4-benzothiazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrochloride (1:1)RUFLOXACIN HClRufloxacin(hydrochloride)
이름 더 보기
9-fluoro-2MF-934 hydrochloride4-benzothiazine-6-carboxylic acidRufloxacin hydrochloride (MF-934)Rufloxacin hydrochloride USP/EP/BPRUFLOXACINHYDROCHLORIDE(SUBJECTTOPATENTFREE)3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1
7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylicacid, 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrochloride(1:1)MFCD009122839-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;hydrochloride2,3-Dihydro-9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride;2,3-Dihydro-9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride9-Fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochlorideCAS-106017-08-7NCGC00074024-02
물성
구조 계산 물성
- 극성 표면적
- 89.4 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 26
- 형식 전하
- 0
- 복잡도
- 608
물리화학적 성질
- 녹는점
- 322 · 322-324℃
- 저장 조건
- -20 °C · -20°C Freezer, Under inert atmosphere
- 용해도
- DMSO(약간 용해됨, 가열), 물(아주 적은 양으로 녹여라)
- 물리적 상태
- 황백색에서 연녹색의 결정성 고체.
- 색상
- 황백색에서 연한 노란색
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 4 (100%)
안전 데이터
- 독성
- LD50 in rats, mice (mg/kg): 285, 224 i.v.; LD50 in rabbits, male, female rats (mg/kg): 660, 631, 501 orally (Cecchetti)
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
응용 분야
개요Rufloxacin hydrochloride is another fluoroquinolone orally active antibacterial structurally and mechanistically related to temafloxacin and tosufloxacin. It is useful for the treatment of respiratory and urinary tract infections and also chronic bacterial prostatitis. Good tissue penetration with long acting activity has been reported.
용도Rufloxacin Hydrochloride inhibits human organic cation transporter 1 (hoCT1) (SLC22A1) but not hOCT2 (SLC22A2), and hOCT3 (SLC22A3) expressed in human embryonic kidney cell.
상·하류 제품 정보
하류 제품
공급사57 곳
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
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