기본 정보
- CAS
2751-68-0- 표준 SMILES
CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2- InChIKey
WNTYBHLDCKXEOT-UHFFFAOYSA-N- 분자식
- C23H29N3O2S
- 평균 분자량
- 411.6 g/mol
- 단동위원소 질량
- 411.19804835
개요
Acetophenazine is a member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the nitogen atom and an acetyl group at position 2. It has a role as a phenothiazine antipsychotic drug. It is a member of phenothiazines, a N-alkylpiperazine and a N-(2-hydroxyethyl)piperazine. It is functionally related to a 10H-phenothiazine.
이름 및 식별자
- 우선 이름
- Acetophenazine
- IUPAC
- 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone
- 현지명
- 아세토펜나진
- 영어명
- ACETOPHENAZINE
- 분자식
- C23H29N3O2S
- 분자량
- 411.56
이름 및 동의어
ACETOPHENAZINE2751-68-0AcetophenazinumAcetofenazina1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)ethan-1-one8620H6K4QHCHEBI:2401DTXSID2022547Ethanone, 1-(10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-10H-phenothiazin-2-yl)-Ethanone, 1-[10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]-1-(10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-10H-phenothiazin-2-yl)ethan-1-oneRefChem:552419
이름 더 보기
아세토펜나진acetoph·Nazine10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl(methyl) ketone
DTXCID202547N05AB07Acetophenazine [INN]1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanoneAcephenazinumAcetophenazina1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)ethanoneAcetophenazinum [INN-Latin]
데이터베이스 식별자
- CAS
물성
구조 계산 물성
- XLogP
- 2.6
- 극성 표면적
- 72.3 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 29
- 형식 전하
- 0
- 복잡도
- 540
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
LogP
3.1
3.37
Solubility6.01e-02 g/L
Melting Point167-168.5
Physical DescriptionSolid
물리화학적 성질
- 끓는 점
- 608.7 · 608.7±55.0 °C(Predicted)
- 밀도
- 1.203 · 1.203±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- 14.96 · 14.96±0.10(Predicted)
화학 및 산업
약리 정보
ATC Code
N - Nervous system
QN - Nervous system
PharmacodynamicsAcetophenzine is a phenothiazine antipsychotic intended for the management of schizophrenia and other psychotic disorders.
Mechanism of Action
Acetophenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Cellular LocationsMembrane
응용 분야
용도Antipsychotic.
공급사10 곳
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