Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
아이소포론 디아민
아이소포론디아민 · 아이소포론 다이아민 · IPDA · ISOPHORONEDIAMINE · ipd · DAIP · D 230 · 3-AMINOMETHYL-3,5,5-TRIMETHYLCYCLOHEXYLAMINE
식별자 및 물리적 특성
| CAS No. | 2855-13-2 |
|---|---|
| 분자식 | C10H22N2 |
| 평균 분자량 | 170.3 g/mol |
| 단동위원소 질량 | 170.1782987 g/mol |
| SMILES | CC1(C)CC(N)CC(C)(CN)C1 |
| InChIKey | RNLHGQLZWXBQNY-UHFFFAOYSA-N |
| PubChem CID | 17857 |
| ChEMBL | CHEMBL1876029 |
| EC No. | 220-666-8 |
| DTXSID | DTXSID6027503 |
| 현지명 | 아이소포론 디아민 |
화학 및 물리적 성질
| XLogP | 1.1 |
|---|---|
| 극성 표면적 | 52 |
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 2 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 12 |
| 형식 전하 | 0 |
| 복잡도 | 165 |
| 물질 분류 | Nitrogen Compounds -> Amines, CyclicCorrosives |
| LogP(분배 계수) | 1.90 (calculated) |
| 냄새 | Characteristic odor |
| 밀도 | 0.924 at 68 °F (USCG, 1999) - Less dense than waterwill float0.922Relative density (water = 1): 0.920.924 g/mL at 20 °C(lit.) |
| Viscosity | 18 mPa*s at 20 °C |
| Color/Form | Colorless liquid |
| 용해도 | Solubility in water at 492 g/l at 23.8 °C: very soluble클로로포름(약간 용해됨), 메탄올(약간 용해됨) |
| Corrosivity | Corrosive |
| 인화점 | 230 °F (USCG, 1999)Flash point =112 °C112 °C c.c.>230 °F |
| 끓는 점 | 477 °F at 760 mmHg (USCG, 1999)247 °C247 °C(lit.) |
| 녹는점 | 50 °F (USCG, 1999)10 °C10 °C(lit.) |
| 증기압 | 0.01 [mmHg]Vapor pressure, Pa at 20 °C: 1.60.02 hPa (20 °C) |
| 굴절률 | n20/D 1.490 |
| 저장 조건 | Store below +30°C. |
| pKa(산도 계수) | 10.57±0.70(Predicted) |
| 물리적 상태 | 액체 |
| 색상 | 투명한 |
| pH | 11.6 (10g/l, H2O, 20℃) |
| 폭발한계 | 1.2%(V) |
| 용해도 | 혼용 가능 |
| 안정성 | 안정적인. 강한 산화제와 호환되지 않습니다. |
| InChI | 1S/C10H22N2/c1-9(2)4-8(12)5-10(3,6-9)7-11/h8H,4-7,11-12H2,1-3H3 |
| InChIKey | RNLHGQLZWXBQNY-UHFFFAOYSA-N |
| SMILES | CC1(C)CC(N)CC(C)(CN)C1 |
| LogP(분배 계수) | 0.99 at 23℃ |
| EPA | Isophorone diamine (2855-13-2) |
화학적 성질
faintly yellow liquid
안전 및 규제
| GHS 분류 | DangerH302: Harmful if swallowed [Warning Acute toxicity, oral]P260, P261, P264, P264+P265, P270, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1340) of reports.H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral] |
|---|---|
| 규제 정보 | Chemical: Cyclohexanemethanamine, 5-amino-1,3,3-trimethyl-Cyclohexanemethanamine, 5-amino-1,3,3-trimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Cyclohexanemethanamine, 5-amino-1,3,3-trimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 28-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14449Isophoronediamine: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| 기타 안전 정보 | IMAP assessments - Cyclohexanemethanamine, 5-amino-1,3,3-trimethyl-: Human health tier II assessment |
| 운송 라벨(DOT) | Corrosive |
| 화재 위험 | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:· Combustible material: may burn but does not ignite readily.Combustible. |
| 건강 유해성 | Inhalation of high concentrations of vapor causes irritation, coughing, and nausea. Eyes: May cause inflammation/burns. Skin: May cause burns. Ingestion: Nausea. (USCG, 1999)· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death. |
| 유해성 요약 | If inhaled, it can provoke coughing and nausea. [CHRIS] An epoxy resin hardener and suspected cause of occupational asthma, isophorone diamine is one component of mixtures causing occupational asthma in two separate documented cases: (1) [Occupational asthma due to EPO 60. Lambourn EM, Hayes JP, McAllister WA, Taylor AJ. Br J Ind Med 1992 Apr49(4):294-5]and (2) [Occupational asthma caused by a hardener containing an aliphatic and a cycloaliphatic diamine. Aleva RM et al. Am Rev Respir Dis 1992 May145(5):1217-8] Corrosive to skin, eyes, and respiratory tractInhalation can cause pulmonary edemaMay cause skin sensitization. [ICSC] Danger of skin sensitization[MAK] Causes burnsInhalation may cause corrosive injuries to upper respiratory tract and lungsHarmful by ingestion[Aldrich MSDS] |
| 운송 번호 및 가이드(DOT) | 2289 153 |
| 반응성 그룹 | Amines, Phosphines, and Pyridines |
| UN 분류 | UN Hazard Class: 8UN Pack Group: III |
| Reactivity Profile | ISOPHORONEDIAMINE is an amine. Amines are chemical bases. They neutralize acids to form salts. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides (Roger Patrick, DuPont Engineer). Corrodes aluminum and steel in the presence of moisture and carbon dioxide (USCG, 1999). |
| Chemical Dangers | Decomposes on heating and on burning. This produces toxic and corrosive gases including nitrogen oxides. Attacks copper, zinc and tin alloys. |
| Packaging and Labelling | Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs. |
| 소화 | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| 응급 조치 | Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention. |
| 누출 비상 조치 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
| 응급 처치 | INHALATION: Move victim to fresh aircall emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.General First Aid: |
| 안전 보관 | Separated from strong oxidants and food and feedstuffs. Ventilation along the floor. Store in an area without drain or sewer access. |
| 노출 관리 및 개인 보호 | · Wear positive pressure self-contained breathing apparatus (SCBA). |
| 비화재 누출 대응 | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: |
| 처리 방법 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| 누출 처리 | Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Do NOT let this chemical enter the environment. |
| Isolation and Evacuation | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:Immediate precautionary measure |
| Eye Prevention | Wear safety goggles, face shield or eye protection in combination with breathing protection. |
| Fire Prevention | NO open flames. |
| 유해 작용 | Dermatotoxin - Skin burns. |
| 노출 경로 | Serious local effects by all routes of exposure. |
| Signs and Symptoms | Sore throat. Cough. Burning sensation. Shortness of breath. Laboured breathing.Pain. Redness. Burning sensation. Blisters. Skin burns.Pain. Redness. Severe deep burns. Loss of vision.Burning sensation. Abdominal pain. Nausea. Vomiting. Diarrhoea. Shock or collapse. |
| ICSC Environmental Data | The substance is harmful to aquatic organisms. |
| TSCA Test Submissions | Isophorone diamine (CAS # 2855-13-2) was evaluated for subchronic inhalation toxicity in male rats (10/dosage group, breed unspecified) administered whole-body exposures to nominal aerosol/vapor concentrations of 18, 200, and 550 mg/cu m, 6 hours/day for 9, 9, and 4 days, respectively. Following 9 exposures, 5 rats from each group (surviving numbers allowing) were sacrificed and necropsied, while the remaining were sacrificed after a subsequent 20-day recovery period. Treatment with 550 mg/m3 was associated with significantly reduced bodyweights and mean bodyweight gains and mortality (4/10) by completion of a fourth exposure, such that all surviving rats (6/10) of this group were sacrificed and necropsied with decedents following the fourth exposure. Dose-dependent histopathology was identified in the nose (18, 200, 550 mg/cu m), trachea (200, 550 mg/cu m), larynx (200, 500 mg/cu m), and lungs (200, 550 mg/cu m). Necrosis as well as hypertrophy/hyperplasia noted in the lungs and trachea of 4-day 550 mg/cu m rats and 9-day rats appeared resolved after 20-day recovery, as tissue repair was also apparent in the nose and larynx of these animals. The study report is summarized only and no further data are provided. |
| Antidote and Emergency Treatment | Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin bums with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Treat seizures with diazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/ |
| 수질 위해 등급(WGK) | 1 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | GV5020833 |
| 운송 번호(UN) | UN 2289 |
| 독성 | LD50 orally in Rabbit: 1030 mg/kg |
| 관세 코드 | 2921 30 99 |
| 위험 문구(R) | 21/22-34-43-52/53 |
| 위험 표시 | C |
| 안전 문구(S) | 26-36/37/39-45-61 |
| 포장분류 | III |
| 위험 등급 | 8Acute Tox. 4 DermalAcute Tox. 4 OralAquatic Chronic 3Eye Dam. 1Skin Corr. 1BSkin Sens. 1A |
| 기존화학 물질 | KE-01487 |
| F 고인화성물질 | 10-21-34 |
| 자연 발화 온도 | 380 °C |
| 저장 분류 | 8A - Combustible corrosive hazardous materials |
| 유해 물질 데이터 | 2855-13-2(Hazardous Substances Data) |
용도
개요
Isophorone diamine is widely used as an epoxy-resin hardener. It is a strong sensitizer and can cause airborne contact dermatitis.
용도
Isophorondiamine mainly used as epoxy curing agents, mainly for applications requiring low color, low odor, high flexural strength and excellent chemical resistance of epoxy formulations. Suitable for floor coatings, fillers and paving mixes.
일반 설명
A clear to light-yellow liquid. Highly soluble though slightly denser than water. May be toxic by inhalation and skin absorption. Corrosive to skin. Used to make other chemicals.
제조 및 합성 방법
생산 방법
Isophorondiamine is made from isophorone nitrile, ammonia, and hydrogen, which leads to simultaneous imination and hydrogenation of the resulting imine and nitrile groups. Catalysts employed are mainly cobalt or ruthenium.