기본 정보
- CAS
127984-74-1- 표준 SMILES
CC(=O)O.CC(C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccc3ccccc3c2)CSSC[C@@H](C(=O)N[C@H](C(N)=O)[C@@H](C)O)NC1=O- InChIKey
DEXPIBGCLCPUHE-UISHROKMSA-N- 분자식
- C56H73N11O12S2
- 평균 분자량
- 1,156.4 g/mol
- 단동위원소 질량
- 1,155.48815915
개요
Lanreotide Acetate is the acetate salt of a synthetic cyclic octapeptide analogue of somatostatin. Lanreotide binds to somatostatin receptors (SSTR), specifically SSTR-2 and also to SSTR-5 with a lesser affinity. However, compare with octreotide, this agent is less potent in inhibiting the release of growth hormone from the pituitary gland. Furthermore, lanreotide has an acute effect on decreasing circulating total and free insulin-like growth factor 1 (IGF-I). This agent is usually given as a prolonged-release microparticle or Autogel formulation for the treatment of acromegaly and to relieve the symptoms of neuroendocrine tumors.
이름 및 식별자
- 우선 이름
- Lanreotide Acetate
- IUPAC
- acetic acid;(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2R)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
- 영어명
- Lanreotide acetate
- 분자식
- C54H69N11O10S2.C2H4O2
- 분자량
- 1156.38
이름 및 동의어
Lanreotide acetateSomatuline LPSomatuline Depot127984-74-1Somatuline AutogelBIM-23014CIEU56G3J9CRefChem:552347DTXSID201027706L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2-7)-disulfide, acetateLanreotide (acetate)2378114-72-6
이름 더 보기
BIM 23014 (acetate)Lanreotide acetate, 10 mM in DMSOLanreotide,Lanreotide acetate,inhibit,hormone,apoptosis,pituitary,BIM23014,Inhibitor,BIM-23014,GH3 cells,tumor,adenoma,GH-secreting,BIM 23014
Somatulineacetic acid;(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2R)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamideL-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2?7)-disulfide, acetate (salt) (9CI); 1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane, cyclic peptide deriv.; BIM 23014C; Lanreotide acetate; Somatulina; SomatulineMFCD00873576orb1299003CHEMBL1201184SCHEMBL29405684SCHEMBL29846268
데이터베이스 식별자
- CAS
127984-74-1- PubChem CID
- 6918010
- ChEMBL
CHEMBL1201184- EC Number
- 694-399-4
물성
구조 계산 물성
- 극성 표면적
- 443 Ų
- 수소 결합 공여자 수
- 14
- 수소 결합 수용자 수
- 16
- 회전 가능 결합 수
- 17
- 무거운 원자 수
- 81
- 형식 전하
- 0
- 복잡도
- 2,030
실험 및 물리화학적 성질
Human Drugs
Breastfeeding; Lactation; Milk, Human; Hormones; Antineoplastic Agents
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 물리적 상태
- Solid
- 색상
- White to off-white
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesRepr. 2 (100%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Lanreotide acetate
Ambiguous-DILI-concern
2
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
화학 및 산업
약리 정보
FDA Pharmacological Classification
LANREOTIDE ACETATE
Somatostatin Analog [EPC]; Somatostatin Receptor Agonists [MoA]
MeSH Pharmacological ClassificationSubstances that inhibit or prevent the proliferation of NEOPLASMS.
공급사112 곳
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