기본 정보
- CAS
2267306-15-8- 표준 SMILES
[N-]=[N+]=NCCOCCOCCOCC(=O)Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O- InChIKey
DUTLUBRCOXPZLI-UHFFFAOYSA-N- 분자식
- C21H24N6O8
- 평균 분자량
- 488.5 g/mol
- 단동위원소 질량
- 488.16556175
이름 및 식별자
- 우선 이름
- Pomalidomide-PEG3-azide
- IUPAC
- 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide
- 영어명
- Pomalidomide-PEG3-N3
- 분자식
- C21H24N6O8
- 분자량
- 488.46
이름 및 동의어
Pomalidomide-PEG3-azide2267306-15-82-(2-(2-(2-AZIDOETHOXY)ETHOXY)ETHOXY)-N-(2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-4-YL)ACETAMIDE2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]acetamidePomalidomide-PEG3-N3orb1691043SCHEMBL23578608C21H24N6O8EX-A15086MFCD32198606AKOS0407575142-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide
이름 더 보기
N3-PEG3-CH2CO-PomaPomalidomide-NH-CO-PEG3-N32-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamideAcetamide, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG3-azide2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
물성
구조 계산 물성
- XLogP
- 0.3
- 극성 표면적
- 155 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 10
- 회전 가능 결합 수
- 13
- 무거운 원자 수
- 35
- 형식 전하
- 0
- 복잡도
- 876
물리화학적 성질
- 녹는점
- 165 °C · 165 °C
- 저장 조건
- 2 · 2-8°C
- 용해도
- 200 mg/mL · DMSO: 200 mg/mL (409.46 mM)
- 물리적 상태
- Solid
- 색상
- White to yellow
- InChIKey
- DUTLUBRCOXPZLI-UHFFFAOYSA-N
- SMILES
- O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCN=[N+]=[N-])=O)=O)NC1=O
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- WGK 3
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
용도Protein degrader builiding block Pomalidomide-PEG3-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
공급사20 곳
郑州汇聚化工有限公司0371-53399770 18037166334 · [email protected]
山东大有药物研发有限公司[email protected] 15165037910 · [email protected]
Shanxi Tihondan Pharmaceutical Technology Co., Ltd+8618235132063 · [email protected]
吉林中科研伸科技有限公司18143011203 · [email protected]
苏州键合化学试剂有限公司0512-69561983 13914027025 · [email protected]
上海毕得医药科技股份有限公司400-164-7117 18317119277 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
Xian confluore Biological Technology Co., Ltd.+86-15680926068 · [email protected]
迪派格（渭南）生物科技有限公司
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