기본 정보
- CAS
57935-66-7- 표준 SMILES
CN1C[C@H](COC(=O)c2cncc(Br)c2)C[C@]2(O)c3cccc4c3c(cn4C)C[C@@H]12- InChIKey
PCKJONBQKJQXEK-ZTWLPKFNSA-N- 분자식
- C23H24BrN3O3
- 평균 분자량
- 470.4 g/mol
- 단동위원소 질량
- 469.1001
이름 및 식별자
- 우선 이름
- Nicergoline EP Impurity E
- IUPAC
- [(6aR,9R,10aS)-10a-hydroxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinolin-9-yl]methyl 5-bromopyridine-3-carboxylate
- 영어명
- Ergoline-8-methanol, 10-hydroxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
- 분자식
- C23H24BrN3O3
- 분자량
- 470.37
이름 및 동의어
Nicergoline EP Impurity E57935-66-710alpha-Hydroxy Nicergoline((6aR,9R,10aS)-10a-hydroxy-4,7-dimethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methyl 5-bromonicotinate10?-Hydroxy Nicergoline10|A-Hydroxy NicergolineNicergolineImpurity210-Hydroxynicergoline10α-Hydroxy NicergolineNicergoline EP Impurity 7Ergoline-8-methanol Indolo[4,3-fg]quinoline DerivativeErgoline-8-methanol, 10-hydroxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
데이터베이스 식별자
- CAS
57935-66-7- PubChem CID
- 14768166
물성
구조 계산 물성
- XLogP
- 2.7
- 극성 표면적
- 67.6 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 4
- 무거운 원자 수
- 30
- 형식 전하
- 0
- 복잡도
- 666
물리화학적 성질
- 끓는 점
- 621.7 · 621.7±55.0 °C(Predicted)
- 밀도
- 1.54 · 1.54±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 13.8 · 13.80±0.40(Predicted)
화학 및 산업
응용 분야
용도10α-Hydroxy Nicergoline is an impurity of Nicergoline (N394550) which is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.
공급사28 곳
济南百隆化学有限公司[email protected] · [email protected]
南京望知星医药科技有限公司18569809817 · [email protected]
广州隽唐科技有限公司020-36607679 13502246435 · [email protected]
Sinco Pharmachem (ShenZhen) R&D Co., Ltd.+86-18603013401 · [email protected]
济南启源生物科技有限公司18766124282; 18766124282 · [email protected]
希瓦生物科技（广州）有限公司13268215580 · [email protected]
上海柯维化学技术有限公司021-64609169 18901607656 · [email protected]
Moxin Chemicals+86-17320513646 +86-17320513646 · [email protected]
杭州云易国科生物科技有限公司18457506494 · [email protected]
北京康派森医药科技有限公司010-010-52878169 15801002657 · [email protected]
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