기본 정보
- CAS
2133360-04-8- 표준 SMILES
[N-]=[N+]=NCCOCC(=O)Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O- InChIKey
SKTGGMFEGRISBY-UHFFFAOYSA-N- 분자식
- C17H16N6O6
- 평균 분자량
- 400.3 g/mol
- 단동위원소 질량
- 400.11313225
이름 및 식별자
- 우선 이름
- Pomalidomide-PEG1-azide
- IUPAC
- 2-(2-azidoethoxy)-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide
- 영어명
- Pomalidomide-PEG1-azide
- 분자식
- C17H16N6O6
- 분자량
- 400.35
이름 및 동의어
Pomalidomide-PEG1-azide2133360-04-8Pomalidomide-NH-PEG1-N32-(2-Azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]acetamide2-(2-azidoethoxy)-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamidePomalidomide-NH-PEG1-azidePomalidomide-amido-PEG1-AzidePomalidomide-NH-CO-PEG1-N3orb1987848SCHEMBL23037446
이름 더 보기
N3-PEG1-CH2CO-PomaAcetamide, 2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-2-(2-Azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG1-azidePomalidomide-PEG1-azide/Acetamide,2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
SCHEMBL29437635C17H16N6O6MFCD32198602AKOS0407437822-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]acetamideBP-40512BP-44903DA-66818
데이터베이스 식별자
- CAS
2133360-04-8- PubChem CID
- 141488037
물성
구조 계산 물성
- XLogP
- 0.6
- 극성 표면적
- 136 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 29
- 형식 전하
- 0
- 복잡도
- 778
물리화학적 성질
- 저장 조건
- 2 · 2-8°C
- 용해도
- 62.5 mg/mL · DMSO : 62.5 mg/mL (156.11 mM; ultrasonic and warming and heat to 60°C)
- 물리적 상태
- Solid
- 색상
- Light yellow to yellow
- InChIKey
- SKTGGMFEGRISBY-UHFFFAOYSA-N
- SMILES
- O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCN=[N+]=[N-])=O)=O)NC1=O
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- WGK 3
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
용도Protein degrader builiding block Pomalidomide-PEG1-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
공급사21 곳
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
山东大有药物研发有限公司[email protected] 15165037910 · [email protected]
吉林中科研伸科技有限公司18143011203 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
Xian confluore Biological Technology Co., Ltd.+86-15680926068 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
迪派格（渭南）生物科技有限公司15114901355 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
长沙博诺新材料科技有限公司18191076804 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
成都标样生物科技有限公司028-81700200 13308200041 · [email protected]
上海超岚化工科技中心QQ：65489617 13301690235 · [email protected]
西安康福诺生物科技有限公司+86-156-80926068 +86-15680926068 · [email protected]
吉林省沃达生物科技有限公司13504435624 · [email protected]
深圳市创鑫生物科技有限公司13417589054 · [email protected]
Aladdin Scientific[email protected]
西安齐岳生物科技有限公司400-400-6966-012-012 17778955912 · [email protected]
上海皓鸿生物医药科技有限公司400-8210725 4008210725 · [email protected]
上海研纷生化科技有限公司17721070236 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
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