인간MCP-1

용도Monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF) has been used: as a chemokine supplement in the alpha minimal essential medium for culturing neurons to test its effect on JmjC histone demethylase (Jmjd2a) mRNAas a component of Dulbecco′s Modified Eagle (DMEM) medium, as a positive chemoattractant control in HeLa cells for migration assayas a chemoattractant to induced macrophage chemotaxis

일반 설명Monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF), also called the C-C motif chemokine ligand 2 (CCL2), is an inflammatory cytokine. The CCL2 gene is mapped to human chromosome 17q12. CCL2 is present in epithelial, endothelial, mesangial and microglial cells. Structurally, it dimerizes and has four regions of the -sheet. Recombinant human MCP-1 is a 8.6 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues. The MCP family cross-reacts across species.