테넥테플라제

용도Treatment of acute thrombotic disorders.

일반 설명Tenecteplase is a tPA produced by recombinant CHO cells.The molecule is a 527-amino acid glycoprotein developed byintroducing the following modifications to the cDNA construct:Thr103 to Asp, Asp117 to Gln, both within the kringle-1domain, and a tetra-alanine substitution at amino acids 296 to299 in the protease domain. The drug is a sterile, lyophilizedpowder recommended for single IV bolus administration afterreconstitution with sterile water. Tenecteplase should be administeredimmediately after reconstitution.