기본 정보
- CAS
320337-48-2- 표준 SMILES
OCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1- InChIKey
KWZZYAKRBYRQTG-UHFFFAOYSA-N- 분자식
- C26H19ClFN3O3
- 평균 분자량
- 475.9 g/mol
- 단동위원소 질량
- 475.1098973
이름 및 식별자
- 우선 이름
- Des(sulfonylethyl)amino Hydroxy Lapatinib
- IUPAC
- [5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]methanol
- 영어명
- Lapatinib IMpurity 8
- 분자식
- C26H19ClFN3O3
- 분자량
- 475.9
이름 및 동의어
320337-48-2Lapatinib Impurity 2Des(sulfonylethyl)amino Hydroxy Lapatinib(5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan-2-yl)methanolCHEMBL3542268[5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]methanol5-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-furanmethanol5-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-furanmethanol;C26H19ClFN3O3SCHEMBL2508037BDBM50235600MFCD30609693
이름 더 보기
Lapatinib Impurity07Lapatinib Impurities FLapatinib Desmesylethylamino Hydroxy ImpLapatinib Desmesylethylamino Hydroxy impurity4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-(5-hydroxymethylfuran-2-yl)quinazoline2-Furanmethanol, 5-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-( 5- ( 4 - ( ( 3 - chloro - 4 - ( ( 3 - fluorobenzyl ) oxy ) phenyl ) amino ) quinazolin - 6 - yl ) furan - 2 - yl ) metha
Des(sulfonylethyl)aminoHydroxyLapatinibA1-04638[5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]-2-furyl]methanol
물성
구조 계산 물성
- XLogP
- 5.5
- 극성 표면적
- 80.4 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 34
- 형식 전하
- 0
- 복잡도
- 648
물리화학적 성질
- 녹는점
- 150 °C · >150°C (dec)
- 저장 조건
- -20 °C · -20°C Freezer, Under inert atmosphere
- 용해도
- DMSO (약간 용해됨), 메탄올(약간 용해됨,가열, 초음파 처리)
- 물리적 상태
- 고체
- 색상
- 연한 노란색에서 밝은 노란색까지
화학 및 산업
응용 분야
용도Des(sulfonylethyl)amino Hydroxy Lapatinib is a compound related to drug Lapatinib (L175808), which is a selective inhibitor of epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. Lapatinib is used to treat breast cancer, especially metastatic breast cancer that has progressed after trastuzumab treatment and other chemotherapy.
공급사30 곳
上海策嵘生物科技有限公司[email protected]
安礼特（上海）医药科技有限公司18109805911 · [email protected]
南京世洲生物科技有限公司025-025-85560043 17301488900 · [email protected]
深圳市简一生物科技有限公司0755-84826604 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
上海尺水药物研究有限公司[email protected] 13564957716 · [email protected]
佛山宝诺生物科技有限公司0757-85921206 18520245316 · [email protected]
大赛璐药物手性技术（上海）有限公司021-50460086-9 15921403865 · [email protected]
Moxin Chemicals+86-17320513646 +86-17320513646 · [email protected]
深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
上海昶衍化工科技有限公司021-20242659 18930833303 · [email protected]
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