Amino-PEG6-t-butyl ester

용도This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation.

일반 설명H2N-PEG6-tBu (CAS 1286281-32-0) is a high-purity, PEG-based PROTAC linker suitable for the synthesis of PROTACs. It has a molecular weight of 409.51 and appears as a colourless to pale yellow viscous liquid or a low-melting-point waxy solid at room temperature. Synonyms include Amino-PEG6-t-butyl ester, NH₂-PEG6-CH₂CH₂COO-tBu, NH₂-PEG6-Boc, H₂N-PEG6-CH₂CH₂COO-tBu and Amino-PEG6-COO-tBu, amongst others.