P 276-00

HCID 178787463
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기본 정보

CAS
936749-12-1
표준 SMILES
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H]1CO.Cl
InChIKey
OOVTUOCTLAERQD-OJMBIDBESA-N
분자식
C21H21Cl2NO5
평균 분자량
438.3 g/mol

개요

Riviciclib Hydrochloride is the hydrochloride salt form of riviciclib, a flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Riviciclib selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.

이름 및 식별자

우선 이름
P 276-00
IUPAC
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one;hydrochloride
영어명
P 276-00
분자식
C21H21Cl2NO5
분자량
438.30114

이름 및 동의어

920113-03-7Riviciclib hydrochlorideP276-00DRP53ZDY6HP-27600P 276-00P-276-004H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl)-, hydrochloride (1:1)RefChem:928418P2762-(2-Chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochlorideRiviciclib HCl
이름 더 보기
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one;hydrochlorideUNII-DRP53ZDY6H2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]-4H-chromen-4-one hydrochloride920113-03-7 (HCl)SCHEMBL663220orb1685539CHEMBL3991935SCHEMBL29387962

데이터베이스 식별자

CAS
936749-12-1
ChEMBL
CHEMBL2312181、CHEMBL3991935
UNII
DRP53ZDY6H

물성

구조 계산 물성

극성 표면적
90.2 Ų
수소 결합 공여자 수
4
수소 결합 수용자 수
6
회전 가능 결합 수
3
무거운 원자 수
29

화학 및 산업

공급사7 곳

Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
Wuhan NCE Biomedical Co.,Ltd.4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
上海孚一生物科技有限公司+86 (21) 61124340
斯派螺（武汉）药物研发有限公司[email protected]
武汉研哲科技有限公司15527250409 · [email protected]

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