디[3-데옥시-D-만노-옥툴로소닐]-지질A(aMMonuM염)
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
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기본 정보
- CAS
1246298-62-3- 표준 SMILES
CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)O[C@@H]1[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@H](OC[C@H]2O[C@H](OP(=O)(O)O)[C@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H]2O)O[C@H](CO[C@]2(C(=O)O)C[C@@H](O[C@]3(C(=O)O)C[C@@H](O)[C@H](O)[C@@H]([C@H](O)CO)O3)[C@H](O)[C@@H]([C@H](O)CO)O2)[C@H]1OP(=O)(O)O.N.N.N.N- InChIKey
HBSUHPVFGADBOQ-RAJSAFOISA-N- 분자식
- C110H214N6O39P2
- 평균 분자량
- 2,306.8405 g/mol
이름 및 식별자
- 우선 이름
- Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
- 현지명
- 디[3-데옥시-D-만노-옥툴로소닐]-지질A(aMMonuM염)
- 영어명
- Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
- 분자식
- C110H214N6O39P2
- 분자량
- 2306.840482
이름 및 동의어
디[3-데옥시-D-만노-옥툴로소닐]-지질A(aMMonuM염)Kdo2-Lipid A (KLA)Kdo2-Lipid AKdo2-Lipid A ammoniumDi[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)DI[3-DEOXY-D-MANNO-OCTULOSONYL]-LIPID A (AMMONIUM SALT)KDO2-LIPID ADi[3-deoxy-D-manno-octulosonyl]-lipid A sodium salt - 0.5mg/ml aqueous solutionO-3-Deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-4)-O-3-deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-6)-O-2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-beta-D-glucopyranosyl-(1-6)-2-deoxy-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-alpha-D-glucopyranose 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate] ammonium salt (1:4)
데이터베이스 식별자
- CAS
1246298-62-3
물성
물리화학적 성질
- 저장 조건
- -20 °C · -20°C
- 물리적 상태
- 고체
- 색상
- White to off-white
- 생물학적 소스
- Escherichia coli
- InChIKey
- HBSUHPVFGADBOQ-RAJSAFOISA-N
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- WGK 3
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
용도Kdo2-Lipid A (KLA) is a nearly homogeneous Re lipopolysaccharide (LPS) substracture with endotoxin activity equal to tha of native LPS. KLA is comparable to LPS and its activity is reduced by >10^3 in cells fro TLR-4 deficient mice.
일반 설명3-deoxy-D-manno-octulosonic acid (Kdo2-Lipid A) is the essential component of lipopolysaccharide in most Gram-negative bacteria and the minimal structural component to sustain bacterial viability. It serves as the active component of lipopolysaccharide to stimulate potent host immune responses through the complex of Toll-like-receptor 4 (TLR4) and myeloid differentiation protein 2 (MD2). Therefore, Kdo2-lipid A is an important stimulator for studying the mechanism of the innate immune system and for developing bacterial vaccine adjuvants. Kdo2 Lipid A/TLR4 antagonists can also be applied in anti-inflammatory interventions. Kdo2-lipid A, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. Kdo2-Lipid A has been used in animal atherosclerosis model.
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