기본 정보
- CAS
12769-48-1- 표준 SMILES
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O- InChIKey
ADNPLDHMAVUMIW-CUZNLEPHSA-N- 분자식
- C63H98N18O13S
- 평균 분자량
- 1,347.6 g/mol
개요
Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurokinin-1 receptor agonist, a neurotransmitter and a vasodilator agent. It is a conjugate base of a substance P(3+).
이름 및 식별자
- 우선 이름
- Substance P
- IUPAC
- (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide
- 영어명
- SUBSTANCE P
- 분자식
- C63H98N18O13S
- 분자량
- 1347.63
이름 및 동의어
Substance P33507-63-0Neurokinin PArg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2Neuropeptide sp-1Sh-oligopeptide-73Substance p (1-11)675VGV5J1DEuler-Gaddum Substance PEuler Gaddum Substance PRefChem:389292Substance P, Hypothalamic
이름 더 보기
RPKPQFFGLMRPKPQQFFGLM-NH2SUBSTANCE P AMIDESUBSTANCE P (TYR8)SUBSTANCE P BOVINESUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE)SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11]H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-METH-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
Substance P, Euler-GaddumSP(1-11)251-545-8(2S)-2-(((2S)-1-((2S)-6-amino-2-(((2S)-1-((2S)-2-amino-5-(diaminomethylideneamino)pentanoyl)pyrrolidine-2-carbonyl)amino)hexanoyl)pyrrolidine-2-carbonyl)amino)-N-((2S)-5-amino-1-(((2S)-1-(((2S)-1-((2-(((2S)-1-(((2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide(2S)-2-((2R)-2-(((2S)-1-((2S)-6-amino-2-(((2R)-1-((2S)-2-amino-5-carbamimidamidopentanoyl)pyrrolidin-2-yl)formamido)hexanoyl)pyrrolidin-2-yl)formamido)-4-carbamoylbutanamido)-N-((1R)-1-(((1R)-1-(((((1R)-1-(((1S)-1-carbamoyl-3-(methylsulfanyl)propyl)carbamoyl)-3-methylbutyl)carbamoyl)methyl)carbamoyl)-2-phenylethyl)carbamoyl)-2-phenylethyl)pentanediamide12769-48-1Substance P acetate saltCHEMBL235363
물성
구조 계산 물성
- XLogP
- -2.3
- 극성 표면적
- 544 Ų
- 수소 결합 공여자 수
- 15
- 수소 결합 수용자 수
- 17
- 회전 가능 결합 수
- 42
- 무거운 원자 수
- 95
- 형식 전하
- 0
- 복잡도
- 2,620
실험 및 물리화학적 성질
LogP-0.56
Collision Cross Section
362.51 Ų [M+H]+ [CCS Type: DT; Method: stepped-field]
496.1 Ų [M+3H]3+
물리화학적 성질
- 저장 조건
- -20 °C · -20°C
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
공급사19 곳
Hangzhou Go Top Peptide Biotech0571-88211921 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
Zhejiang J&C Biological Technology Co.,Limited+1-2135480471 · [email protected]
宝鸡缔都医药化工有限公司029-81145305 17791533577 · [email protected]
LEON (NANJING) BIOTECHNOLOGY CO., LTD.15051830413 · [email protected]
Moxin Chemicals+86-17320513646 +86-17320513646 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
石家庄瑞田生化有限公司15831127780 · [email protected]
南京莱昂生物科技有限公司025-84523390 -127; 17705183659 · [email protected]
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