기본 정보
- CAS
156680-74-9- 표준 SMILES
C[C@]12CCCCC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)[C@H](F)C[C@@H]12- InChIKey
VHZXNQKVFDBFIK-NBBHSKLNSA-N- 분자식
- C19H27FO
- 평균 분자량
- 290.4 g/mol
개요
Has antiproliferative effects on HIV-1 and reduces HIV-1 replication.
이름 및 식별자
- 우선 이름
- Fluasterone
- IUPAC
- (8R,9S,10R,13S,14S,16R)-16-fluoro-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
- 현지명
- 플루스테론
- 영어명
- fluasterone
- 분자식
- C19H27FO
- 분자량
- 290.4154832
이름 및 동의어
Fluasterone112859-71-916alpha-Fluoroandrost-5-en-17-oneR7M5UGD04GDTXSID90920920RefChem:599317DTXCID401349821Dehydroepiandrosterone Analog 8354(1S,2R,10R,11S,13R,15S)-13-fluoro-2,15-dimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadec-7-en-14-one(8R,9S,10R,13S,14S,16R)-16-fluoro-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one156680-74-9CHEMBL4441355
이름 더 보기
플루스테론
16alpha-Fluoro-5-androsten-17-oneUNII-R7M5UGD04G16-fluoro-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-oneCCRIS 4216(8R,9S,10R,13S,14S,16R)-16-Fluoro-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-oneVHZXNQKVFDBFIK-NBBHSKLNSA-N8354 compoundHE2500
데이터베이스 식별자
- CAS
156680-74-9- ChEMBL
CHEMBL4441355- UNII
물성
구조 계산 물성
- XLogP
- 5.1
- 극성 표면적
- 17.1 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 0
- 무거운 원자 수
- 21
- 형식 전하
- 0
- 복잡도
- 510
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
화학 및 산업
약리 정보
Mechanism of Action
Fluasterone is a synthetically stable adrenocortical steroid fluorinated analogue of dehydroepiandrosterone (DHEA), a powerful anti-inflammatory molecule with androgenic or estrogenic side effects. It is proposed that fluasterone inhibits NF-kB activation and reduces oxidative stress, but other mechanisms may play a role. Fluasterone suppresses inflammation and is effective in preclinical models of chronic inflammatory disease including psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and lupus erythematosus. Fluasterone has anti-inflammatory effects inpreclinical models of chronic inflammatory disease including psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and lupus erythematosus. [Aeson Pharmaceuticals Executive Report]
공급사1 곳
HONEST JOY HOLDINGS LIMITED[email protected]
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