Davunetide
기본 정보
- CAS
132031-50-6- 표준 SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)CC(N)=O)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)O- InChIKey
DWLTUUXCVGVRAV-XWRHUKJGSA-N- 분자식
- C36H60N10O12
- 평균 분자량
- 824.9 g/mol
개요
Davunetide is an oligopeptide.
이름 및 식별자
- 우선 이름
- Davunetide
- IUPAC
- (2S)-5-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid
- 영어명
- H-Ser-Phe-Glu-Arg-Phe-Glu-Ile-Phe-Pro-Lys-OH
- 분자식
- C63H90N14O16
- 분자량
- 1299.47
이름 및 동의어
Davunetide211439-12-2NAP peptideNAPVSIPQ peptideDavunetidaAL108 cpdAL208 cpdAL-108AL-208GF00K3IIWEL-Glutamine, L-asparaginyl-L-alanyl-L-prolyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-(2S)-5-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid
이름 더 보기
SFERFEIFPKINFLUENZA HA (110-119)Activity-Dependent NeuroprotectiveSER-PHE-GLU-ARG-PHE-GLU-ILE-PHE-PRO-LYSH-Ser-Phe-Glu-Arg-Phe-Glu-Ile-Phe-Pro-Lys-OHINFLUENZA PR8 HEMAGGLUTININ PEPTIDE (110-119)L-Lysine, L-seryl-L-phenylalanyl-L-α-glutamyl-L-arginyl-L-phenylalanyl-L-α-glutamyl-L-isoleucyl-L-phenylalanyl-L-prolyl-
Human activity-dependent neuroprotective protein (ADNP)-(354-361)-peptidedavunetidum(2S)-5-amino-2-(((2S)-1-((2S,3S)-2-(((2S)-2-(((2S)-2-(((2S)-1-((2S)-2-(((2S)-2,4-diamino-4-oxobutanoyl)amino)propanoyl)pyrrolidine-2-carbonyl)amino)-3-methylbutanoyl)amino)-3-hydroxypropanoyl)amino)-3-methylpentanoyl)pyrrolidine-2-carbonyl)amino)-5-oxopentanoic acidRefChem:585209L-Asparaginyl-L-alanyl-L-prolyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-glutamineNAPVSIPQ132031-50-6D-NAP peptide
물성
구조 계산 물성
- XLogP
- -5.6
- 극성 표면적
- 356 Ų
- 수소 결합 공여자 수
- 10
- 수소 결합 수용자 수
- 13
- 회전 가능 결합 수
- 22
- 무거운 원자 수
- 58
- 형식 전하
- 0
- 복잡도
- 1,560
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
물리화학적 성질
- 밀도
- 1.4 · 1.40±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 3.6 · 3.60±0.21(Predicted)
화학 및 산업
약리 정보
Mechanism of Action
Davunetide interacts with microtubules 1) preventing the formation of neurofibrillary tanges and protecting the network from a 'death signal' or 2) repairing the network if the brain cell death process has already begun. The restoration of the microtubule network explains the results shown in treated animals which have improved cognitive performance compared to untreated groups.
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