폴리(12-아미노도데칸산 라우로락탐)

FCS -> FDA Cumulative Estimated Daily Intake (CEDI)

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Dry Powder; Large Crystals

Solid; [eChemPortal: SIDSUNEP] Very faintly beige crystalline lumps; [MSDSonline]

This chemical does not meet GHS hazard criteria for 96.6% (115 of 119) of all reports.

Not Classified

Aggregated GHS information provided per 119 reports by companies from 2 notifications to the ECHA C&L Inventory.

Warning

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P260, P264, P270, P273, P308+P316, P405, and P501 (click each P-code to see the statement)

Chemical: Azacyclotridecan-2-one

Azacyclotridecan-2-one is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Azacyclotridecan-2-one are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 12-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13738

Not Classified

Specific target organ toxicity - Single exposure - Category 2 (central nervous system, digestive system)

ALL THE THIOLACTAMS STUDIED CAUSED CLONIC AND TONIC CONVULSIONS IN MICE A FEW SEC AFTER IP ADMIN. THE VARIATION IN THE ACUTE BASAL TOXICITY OF THE THIOLACTAMS WAS MAINLY DUE TO THE CHANGE IN THE LIPOHYDROPHILIC CHARACTER. THE DIPOLE MOMENT APPEARS TO PLAY A SIGNIFICANT ROLE IN DETERMINING THE CONVULSANT ACTIVITY IN THE TOXICITY OF THIOLACTAMS, LACTAMS, & GAMMA-THIOBUTYROLACTONE.

FOR LACTAMS WITH SMALL RING SIZE, CNS STIMULATION APPEARED TO BE DOMINANT IN MICE THAT WERE INJECTED IP WITH A SERIES OF LOGARITHMIC DOSES (30, 100, 300, AND 1000 MG/KG (GROUPS OF 6 ANIMALS, 3 MALES & 3 FEMALES). 2-AZACYCLOTRIDECANONE CAUSED TREMBLING AT 500 MG/KG IN 6/6 MICE.

Plastics Product Manufacturing

Azacyclotridecan-2-one: ACTIVE