기본 정보
- CAS
627090-10-2- 표준 SMILES
NOCC(=O)NNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C(O)C(F)(F)F- InChIKey
YJYRTJQOEOYKFD-AEXHUXLESA-N- 분자식
- C14H22F3N5O6S
- 평균 분자량
- 445.42 g/mol
이름 및 식별자
- 우선 이름
- Aldehyde Reactive Probe (trifluoroacetate salt)
- IUPAC
- 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N'-(2-aminooxyacetyl)pentanehydrazide;2,2,2-trifluoroacetic acid
- 현지명
- 알데히드반응성프로브(트리플루오로아세테이트염)
- 영어명
- Aldehyde Reactive Probe (trifluoroacetate salt)
- 분자식
- C14H22F3N5O6S
- 분자량
- 445.41
이름 및 동의어
627090-10-2Aldehyde Reactive Probe (trifluoroacetate salt)5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N'-(2-aminooxyacetyl)pentanehydrazide;2,2,2-trifluoroacetic acidAldehyde reactive probe (TFA)ALDEHYDE REACTIVE PROBE TFAN'-(2-(Aminooxy)acetyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanehydrazide 2,2,2-trifluoroacetateYJYRTJQOEOYKFD-AEXHUXLESA-Norb1694498C14H22F3N5O6SARP, 95%EX-A14768MFCD03427750
이름 더 보기
알데히드반응성프로브(트리플루오로아세테이트염)Aldehyde Reactive ProbeARP [N-(AMinooxyacetyl)-N'-(D-biotinoyl) hydrazine, trifluoroacetic acid salt]
AKOS040754706PD019824HY-135136CS-0109562H67374T35575N-(Aminooxyacetyl)-N'-D-biotinoyl)hydrazine, 96%ARP [N-(AMinooxyacetyl)-N'-(D-biotinoyl) hydrazine, trifluoroacetic acid salt]
데이터베이스 식별자
물성
구조 계산 물성
- 극성 표면적
- 197 Ų
- 수소 결합 공여자 수
- 6
- 수소 결합 수용자 수
- 11
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 29
- 형식 전하
- 0
- 복잡도
- 519
물리화학적 성질
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 20 mg/ml; · DMF: 20 mg/ml; DMSO: 15 mg/ml; PBS (pH 7.2): 3 mg/ml
- 물리적 상태
- 결정성 고체
화학 및 산업
응용 분야
개요DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites. The biotin-tagged DNA can then be detected using common avidin-conjugated reporters such as avidin-HRP. The ARP method is highly sensitive, enabling detection of 2.4 AP sites per 1x107 nucleotides of DNA.
공급사19 곳
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