아닐린과결합된벤젠아민,디아조화,축합생성물

Fight fire from maximum distance. Dike fire control water for later disposal and do not scatter material. If a leak or spill has not ignited, use water spray to control vapors. Wear self-contained breathing apparatus with a full face piece operated in pressure-demand or other positive pressure mode and special protective clothing.

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Administration of oxygen may be needed. Refer immediately for medical attention.

Administration of oxygen may be needed. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Administration of oxygen may be needed. Rinse mouth. Do NOT induce vomiting. Rest. Refer immediately for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

Signs and Symptoms of Acute Aniline Exposure: Signs and symptoms of acute exposure to aniline may be severe and include dyspnea (shortness of breath), respiratory paralysis, cardiac arrhythmias, and cardiovascular collapse. Victims may experience headache, irritability, disorientation, lethargy, weakness, incoordination, dizziness, and drowsiness. Delerium, shock, convulsions, and coma may also be observed. Gastrointestinal effects include dryness of throat, nausea, and vomiting. Painful urination, oliguria (scanty urination), and hematuria (bloody urine) may occur. Aniline may irritate the skin, eyes, and mucous membranes; cyanosis (blue tint to skin and mucous membranes) is a common finding.

General First Aid:

(General first aid procedures)

Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Storage containers and parts of containers may rocket great distances, in many directions.

· Wear positive pressure self-contained breathing apparatus (SCBA).

Biological Exposure Indices (BEI) [ACGIH] - Total p-aminophenol in urine = 50 mg/L; sample at end of shift; (See notations in ACGIH TLVs and BEIs.)

2.0 [ppm]

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

To fight fire, use alcohol foam, carbon dioxide, dry chemical.

For more Fire Fighting Procedures (Complete) data for Aniline (8 total), please visit the HSDB record page.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Store in cool, dry, well-ventilated location away from fire hazards and reactive materials.

Separated from strong oxidants, strong acids and food and feedstuffs. Well closed. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.

Aniline is slightly corrosive to some types of metal. So all amphoteric materials such as aluminum, copper, tin, zinc, and alloys containing one of these metals (brass, bronze) are not suitable for the handling of aniline, as they are corroded by it. For normal applications carbon steel or cast iron are appropriate materials for the aniline handling or storage. Only if discoloration must be kept to minimum, aniline should be stored and transported in stainless steel equipment with proper nitrogen blanketing.

For more Storage Conditions (Complete) data for Aniline (6 total), please visit the HSDB record page.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal

Wear breathing apparatus, eye protection, laboratory coat, and butyl rubber gloves. Cover the spill with a 1:1:1 mixture by weight of sodium carbonate or calcium carbonate, clay cat litter (bentonite), and sand. When the aniline has been absorbed, scoop the mixture into a plastic pail and add enough water to dissolve the sodium carbonate. Allow the solids to settle and decant the liquid to another container. Discard the solids with the normal refuse. To the liquidd, slowly (frothing will occur) add 6 M sulfuric acid to pH 2. Stir into the acidified solution sufficient solid potassium permanganate so that the liquid is purple (a drop of the liquid on filter paper will show a purple ring). Allow the mixture to stand at room temperature for 48 hours, and then neutralize with solid sodium carbonate (frothing will occur), or with a 10% aqueous solution of sodium hydroxide. Add solid sodium bisulfite until the solution is colorless. Decant the clear liquid into the drain and discard any brown solid with normal refuse.

Evacuate persons not wearing protective equipment from area of spill or leak until cleanup is complete. Stay upwind; keep out of low areas. Establish forced ventilation to keep levels below explosive limit. Wear positive pressure breathing apparatus and special protective clothing. Remove all ignition sources: no flares, smoking, or flames in hazard area. Do not touch material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with vermiculite, dry sand, earth, or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream uses of potentially contaminated waters. ...

Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U012, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Dissolve the aniline (1 mL) in 50 mL of 3 M sulfuric acid (prepared by slowly adding 8 mL of concentrated sulfuric acid to 21 mL of water). Weigh 10 g of potassium permanganate and stir small portions of the solid into the aniline solution over a period of about 1 hour. Stir the mixture at room temperature for 48 hours, and then neutralize the solution by adding solid sodium carbonate or a 10% solution of sodium hydroxide. Add solid sodium bisulfite until solution is colorless. Decant the clear liquid into the drain and discard any brown solid with regular refuse.

For more Disposal Methods (Complete) data for Aniline (18 total), please visit the HSDB record page.

Mean hemoglobin adduct levels of aromatic amines in 12 smokers blood samples were aniline 4.4, o-toluidine 0.10, m-toludine 0.49, p-toluidine 0.13, 22-aminoaphtalene 0.015, and 4-aminobiphenyl 0.17 ng/g. Mean levels of these compound in nonsmokers were 3.8, 0.034, 0.68, 0.070, 0.006, and 0.025 ng/g, respectively.

Immune

[bladder cancer]

Present study was designed to evaluate the protective effects of protocatechuic acid alone and in combination with ascorbic acid in aniline hydrochloride induced spleen toxicity in rats. Male Wistar rats of either sex (200-250 g) were used and divided into different groups. Spleen toxicity was induced by aniline hydrochloride (100 ppm) in drinking water for a period of 28 days. Treatment group received protocatechuic acid (40 mg/kg/day, p.o.), ascorbic acid (40 mg/kg/day, p.o.), and combination of protocatechuic acid (20 mg/kg/day, p.o.) and ascorbic acid (20 mg/kg/day, p.o.) followed by aniline hydrochloride. At the end of treatment period serum and tissue parameters were evaluated. Rats supplemented with aniline hydrochloride showed a significant alteration in body weight, spleen weight, feed consumption, water intake, hematological parameters (hemoglobin content, red blood cells, white blood cells, and total iron content), tissue parameters (lipid peroxidation, reduced glutathione, and nitric oxide content), and membrane bound phosphatase (ATPase) compared to control group. Histopathology of aniline hydrochloride induced spleen showed significant damage compared to control rats. Treatment with protocatechuic acid along with ascorbic acid showed better protection as compared to protocatechuic acid or ascorbic acid alone in aniline hydrochloride induced spleen toxicity. Treatment with protocatechuic acid and ascorbic acid in combination showed significant protection in aniline hydrochloride induced splenic toxicity in rats. /Aniline hydrochloride/

Present study was designed to evaluate the protective effects of ethanolic extract of Dioscorea alata L. (DA) on hematological and biochemical changes in aniline-induced spleen toxicity in rats. Wistar rats of either sex (200-250 g) were used in the study and each group contains six rats. Splenic toxicity was induced in rats by administration of aniline hydrochloride (AH; 100 ppm) in drinking water for a period of 30 days. Treatment groups received DA (50 and 100 mg/kg/day, po) along with AH. At the end of treatment period, various serum and tissue parameters were evaluated. Rats administered with AH (100 ppm) in drinking water for 30 days showed a significant alteration in general parameters (organ weight, body weight, water intake, feed consumption, and fecal matter content), hematological parameters (red blood cell (RBC), white blood cell (WBC), and hemoglobin content), and biochemical parameters (total iron content, lipid peroxidation, reduced glutathione (GSH), and nitric oxide (NO) content) of spleen. Treatment with DA (50 and 100 mg/kg/day, po) for 30 days along with AH showed significant recovery in aniline-induced splenic toxicity. The present result showed that involvement of oxidative and nitrosative stress in aniline-induced splenic toxicity and DA protects the rats from the toxicity, which might be due to its antioxidant property and the presence of different phytochemicals.

Aniline and o-toluidine were nonmutagenic in Salmonella typhimurium. However, combination of norharman /SRP: P450 inducer/ (2,9-diazafluorene) with either compound resulted in significant mutagenicity.

Diffusion cells were used to investigate the effects of two skin barrier creams (SBC) and one skin care cream (SCC) on percutaneous penetration of neat aniline... . The experiments were carried out with untreated and with skin creams treated human skin. A considerable percutaneous penetration enhancement ... was observed for treated skin compared with untreated skin; the highest enhancement (mean factors 6.2-12.3) was found for SBC (based on oil in water emulsion) treated skin. The lowest penetration enhancement showed SCC treated skin (mean factors 4.2-9.7). The in vitro data support /previous/ findings in workers that the percutaneous absorption of aromatic amines significantly increases in presence of skin creams. The efficacy of skin creams to protect the percutaneous penetration of aromatic amines is not confirmed...

For more Interactions (Complete) data for Aniline (12 total), please visit the HSDB record page.

Hematologic

Blood, cardiovascular system, eyes, liver, kidneys, respiratory system

LC50; Species: Ambystoma mexicanum (Mexican axolotl) 3-4 weeks after hatching; Concentration: 440 mg/L for 48 hr /Conditions of bioassay not specified/

LC50; Species: Xenopus laevis (clawed frog) 3-4 weeks after hatching; Concentration: 560 mg/L for 48 hr /Conditions of bioassay not specified/

LC50; Species: Carassius auratus (goldfish) 0 exposure days beyond hatching; Conditions: hardness 50 mg/L CaCO3; Concentration: 10.2 mg/L /Conditions of bioassay not specified/

LC50; Species: Carassius auratus (goldfish) 4 exposure days beyond hatching; Conditions: hardness 50 mg/L CaCO3; Concentration: 5.6 mg/L /Conditions of bioassay not specified/

For more Ecotoxicity Values (Complete) data for Aniline (108 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values in the range of 43.8-497.7 in five European soils(2) and 8-137 in five second-generation European reference soils(3), indicate that aniline is expected to have high to moderate mobility in soil(SRC). The pKa of aniline is 4.60(4), indicating that this compound may partially exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Anilines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(6,7), suggesting that mobility may be much lower in some soils. Volatilization of aniline from moist soil surfaces may be an important fate process(SRC) given a Henry's Law constant of 2.02X10-6 atm-cu m/mole(8). Aniline is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.667 mm Hg at 25 °C(9). An 85% of theoretical BOD(NH3) after 2 weeks using activated sludge in the Japanese MITI test(10) indicates that biodegradation is an important environmental fate process in soil(SRC).

TERRESTRIAL FATE: The effects of low temperature and accelerated soil solution contact on soil adsorption of labile organic chemicals were investigated in lab experiments. Kinetics of adsorption and degradation were measured for (14)C-labeled aniline, benzoic acid, phenol, and diuron in the soln phase at 3 and 22 °C. In the initial stages of reaction, the adsorption of all 4 chemicals was instantaneous at both temperatures under accelerated soil and solution mixing. A steady state was observed after the onset of equilibrium for the adsorption reaction for all compounds within 10-30 minutes. Its length varied according to the expected order of susceptibility to microbial degradation, ie, diuron > aniline > phenol greater than or equal to benzoate. The steady state period without or in combination with low temperature could be used to obtain adsorption measurements in active microbial systems. Minimal interference from solute transformations in the solution phase would be expected from soil microorganisms.

AQUATIC FATE: Based on a classification scheme(1), Koc values in the range of 43.8-497.7 in five European soils(2) and 8-137 in five second-generation European reference soils(3), indicate that aniline is not expected to adsorb to suspended solids and sediment(SRC). Volatilization of the neutral species from water surfaces may be expected(4) based upon a Henry's Law constant of 2.02X10-6 atm-cu m/mole(5). A pKa of 4.60(6) indicates aniline may exist partially in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process for the ionized species(SRC). According to a classification scheme(7), an experimental BCF of less than 1(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). An 85% of theoretical BOD(NH3) after 2 weeks using activated sludge in the Japanese MITI test(9) indicates that biodegradation is an important environmental fate process in water(SRC). Aniline reached 19.3% degradation after 5 hours of sunlight irradiation(10), suggesting that photolysis may be an important process in sunlit water surfaces(SRC).

In a study published in 1977, aniline was detected in 14 of 16 samples of fresh fruits, vegetables, salad and maize in Germany at concentrations of 0.6-30.9 ppm; aniline was detected in preserved vegetables from Germany at concentrations of <0.1 ppm and animal feed at 120 ppm(1). Aniline was identified, not quantified, as a volatile component of black tea(2). Aniline was detected in the volatile component of garlic bulbs at concentrations of 0.005-10.52 ppm(3).

The substance can be absorbed into the body by inhalation, through the skin also as a vapour and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Toxic by ingestion and a skin and eye irritant.

IDENTIFICATION AND USE: Aniline is an oily liquid, which is colorless when freshly distilled, but darkens in exposure to air and light. It is used in manufacture dyes, pharmaceuticals, resins, varnishes, perfumes, shoe blacks, vulcanizing rubber, and as a solvent. The hydrochloride form is used in the manufacture of intermediates, aniline black and other dyes, in dyeing fabrics or wood black. HUMAN STUDIES: Single oral doses of 25-65 mg/person of aniline caused a dose dependent increase in methemoglobin formation. Doses of 45-65 mg/person also produced a slight increase in serum bilirubin in two subjects. Methemoglobin levels exceeding 70% are potentially lethal if untreated. Acute or delayed (2 to 7 days) hemolytic anemia (caused by destruction of red blood cells) has also results from aniline exposure. Moderate skin irritation and sensitization and dermatitis have been reported. Aniline can cause mild to severe eye irritation, corneal damage, and discoloration. Systemic effects can result from skin contact with aniline vapor or liquid. Acute aniline exposure can cause confusion, ringing in the ears, weakness, disorientation, dizziness, impaired gait, lethargy drowsiness, convulsions, loss of consciousness, and coma. These effects are usually transitory and probably secondary to lack of oxygen. Inhalation of aniline can cause respiratory tract irritation with cough, or difficulty in breathing. Inhaled aniline is rapidly and almost completely absorbed from the lungs, leading to systemic toxicity. Acute aniline exposure can cause painful urination; blood, hemoglobin or methemoglobin in the urine; decreased urinary output, and acute kidney failure. Bladder-wall irritation, kidney ulceration, and tissue death can also occur. Cardiac effects of acute aniline exposure, such as irregular heart rhythm, heart block, and acute congestive heart failure, may be caused by decreased oxygen delivery to the tissues. Death can result from progressive acidosis, ischemia and cardiovascular collapse. Chronic exposure to aniline may cause anemia, headaches, tremor, parathesis, pain, CNS depression or coma, and cardiac arrhythmia. Heart, kidney, and liver damage may also occur, possibly as secondary effects of hemolysis. Aniline can cross the placental barrier. Because fetal hemoglobin is more easily oxidized to methemoglobin than is adult hemoglobin and is less easily reduced back to normal hemoglobin, methemoglobin is likely to be at higher levels in fetuses than in exposed mothers. Genotoxicity and cytotoxicity of aniline hydrochloride (0.05-10.0 mmolar) on human fibroblasts were studied. Increases in sister chromatid exchange (SCE) frequencies were significant in cells exposed in serum free medium for 2 hr. Toxic Oil Syndrome is a multisystemic disease that occurred in epidemic proportions in Spain in 1981 caused by the ingestion of rapeseed oil denatured with aniline. Several data implicate T cells in the pathogenesis of the disease. ANIMAL STUDIES: Repeated daily subcutaneous administration of aniline to rats caused a decrease in steroidogenesis and lipid accumulation in corpora lutea and adrenal cortex. Aniline-induced splenic toxicity is characterized by hemorrhage, capsular hyperplasia, fibrosis, and a variety of sarcomas in rats. A spongy change in the spinal cord white matter was observed in four-week-old rats treated with aniline. Aniline in vivo is rapidly converted to paracetamol by the liver. Intrauterine exposure to aniline and paracetamol in environmental and pharmaceutical relevant doses resulted in shortening of the anogenital distance in mice, a marker of fetal androgen levels that in humans is associated with reproductive malformations and later life reproductive disorders. Aniline produced generally negative results in reverse mutation assays using Salmonella typhimurium. Aniline was reported to show positive results in the L5178+/- mouse lymphoma gene mutation assay. ECOTOXICITY STUDIES: A 90 day outdoor bioassay with tilapia showed that 0.02 mg/L aniline reduced fish yield, specific growth rate and food conversion efficiency. Reproductive functions of fish were affected by aniline at a concentration of 0.5 mg/L and above. Dissolved oxygen, primary productivity and plankton population of the test medium also were significantly reduced at 2.65 and 6.94 mg/L aniline. The mitotic index of wheat root tip cells decreased when the aniline test concentration was higher than 10 mg/L. The frequency of micronucleus and chromosomal aberrations increased at aniline concentrations ranging between 5 and 100 mg/L.

/AQUATIC SPECIES/ Environmental risk assessments show increased attention to the sublethal effects of chemicals on aquatic organisms. The Organization for Economic Cooperation and Development (OECD) established the "Fish, Short-term Toxicity Test on Embryo and Sac-fry Stages" (OECD test 212) to predict lethal effects. It is still unclear, however, whether this test can predict sublethal effects. Although their sublethal effects are still unknown, chlorinated anilines are widely used in various fields. The purpose of this study, therefore, is to investigate sublethal effects of chlorinated anilines using OECD test 212 with zebrafish, and to examine the correlation of several sublethal effects between embryo and larval stages. Embryos were exposed to aniline and nine chlorinated anilines until 8 days post-fertilization. A delayed lethal effect was observed from three of the 10 anilines tested. In the control group, the swim bladder inflated after hatching, but there was no swim-bladder inflation after exposure to the chlorinated anilines. Fertilized eggs exposed to lower concentrations of test chemicals showed effects during embryogenesis that did not affect mortality rates, such as changes in body curvature and edema. ...Results show that chlorinated anilines induce not only lethal effects but also a variety of sublethal effects. Moreover, a detailed estimate of these effects requires study during both embryonic and larval stages. /chlorinated anilines/

/AQUATIC SPECIES/ The acute and chronic toxicities of aniline to tilapia (Oreochromis mossambicus), cladoceran crusatcea (Moina micrura) and oligochaete worm (Branchiura sowerbyi) /were determined/ using static bioassay tests. The 96 hr LC50 values of aniline for O. mossambicus, M. micrura and B. sowerbyi were 69.4, 0.6 and 586 mg/L, respectively. Tilapia responded to even low concentrations of aniline: the fish lost appetite at aniline concentrations as low as 0.02 mg/L. A 90 day outdoor bioassay with tilapia showed that 0.02 mg/L aniline reduced fish yield, specific growth rate and food conversion efficiency. Reproductive functions of fish were affected by aniline at a concentration of 0.5 mg/L and above. Dissolved oxygen, primary productivity and plankton population of the test medium also were significantly reduced at 2.65 and 6.94 mg/L aniline.

/AQUATIC SPECIES/ This test series developed methods for testing a complement of aquatic organisms in a single test that satisifies the freshwater acute toxicity requirements for setting water quality criteria. Species tested included fathead minnows (Pimephales promelas), rainbow trout (Salmo gairdneri), bluegill (Lepomis macrochirus), channel catfish (Ictalurus punctatus), goldfish (Carassius auratus), white sucker (Catostomus commersoni), daphnid (Daphnia magna), midge (Tanytarsus dissimilis), crayfish (Orconectes immunis), snail (Aplexa hypnorum), tadpole (Xenopus laevis), and leech (Nephelopsis obscuro). Five to 9 of the preceding species were simultaneously exposed in individual tests. ... Aniline was the least toxic to most species, although it is very toxic to Daphnia.

U012; As stipulated in 40 CFR 261.33, when aniline, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Aniline is included on this list. Effective date 10/04/82; Sunset date: 10/04/92.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Aniline is included on this list.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Aniline is produced, as an intermediate or a final product, by process units covered under this subpart.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Aniline is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 1000 lbs.

Aniline is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

Aniline is predominantly used as a chemical intermediate for the dye, agricultural, polymer, and rubber industries. It is also used as a solvent, and has been used as an antiknock compound for gasolines.

Used in the synthesis of dyes, rubber additives, drugs, photographic chemicals, isocyanates, and pesticides. [ACGIH] Shake-out operators and other foundry workers were exposed to aniline from the decomposition of heated cold-box binders. [Appl Occup Environ Hyg 2001 Jan;16(1):66-77]

Shakeout, Cleaning, and Finishing [Category: Foundry]

Smoking cigarettes [Category: Food & Drugs]

For aniline (USEPA/OPP Pesticide Code: 251400) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Manufacture dyes, medicinals, resins, varnishes, perfumes, shoe blacks; vulcanizing rubber; as solvent. Hydrochloride used in manufature of intermediates, aniline black and other dyes, in dyeing fabrics or wood black.

(1977) 5.71X10+7 G

(1982) 7.31X10+7 G

(1985) 5.15X10+7 g

(1998) 45 million lbs

2023: 1,000,000,000 - <2,500,000,000 lb

(1977) 2.65X10+11 G

(1982) 2.53X10+11 G

(1983) 3.01x10+11 G

(1985) 3.25X10+11 g

For more U.S. Production (Complete) data for Aniline (11 total), please visit the HSDB record page.

CHEM INT FOR METHYLENEDIISOCYANATE, 59%; CHEM INT FOR RUBBER CHEMS, 24%; CHEM INT FOR DYES & PIGMENTS, 4%; CHEM INT FOR HYDROQUINONE, 3%; OTHER USES, 10% (1980)

Isocyanates, 60%; rubber chem, 20%; agricultural (pesticides), 8%; dyes & pigments, 4%; misc, 8% (1985)

CHEMICAL PROFILE: Aniline. Polymeric and "pure" MDI (p,p-methylene diphenyl di-isocyanate), 65%; rubber-processing chemicals, 13%; herbicides, 7%; dyes and pigments, 3%; fibers, 2%; export, 4%; miscellaneous, including pharmaceuticals and photo chemicals 6%.

CHEMICAL PROFILE: Aniline. Demand: 1986: 830 million lb; 1987: 870 million lb; 1991 /projected/: 1.010 million lb.

For more Consumption Patterns (Complete) data for Aniline (6 total), please visit the HSDB record page.

Nitrobenzene is hydrogenated to aniline, usually in more than 99% yield, using fixed-bed or fluidized-bed vapor-phase processes. The most effective catalysts for the gas-phase hydrogenation of nitrobenzene seem to be copper or palladium on activated carbon or an oxidic support, in combination with other metals (Pb, V, P, Cr) as modifiers or promoters in order to achieve high activity and selectivity.

The industrial aniline processes of ICI and DuPont involve hydrogenation /of nitrobenzene/ in the liquid phase. Liquid-phase hydrogenation processes are operated at 90-200 °C and 100-600 kPa. The liquid phase reaction may be carried out in slurry or in fluidized-bed reactors. Conversion of nitrobenzene is normally complete after a single reactor pass with yields of 98 to 99%.

In the commercial phenol route developed by Halcon, phenol is aminated in the vapor phase using ammonia in the presence of a silica-alumina catalyst. ... The reaction is mildly exothermic (H = - 8.4 kJ/mol) and reversible, so high conversion is obtained only by the use of excess ammonia (mole ratio of 20:1) and a low reaction temperature, which also reduces the dissociation of ammonia. Byproduct impurities include diphenylamine, triphenylamine and carbazole. Their formation is also inhibited by the use of excess ammonia. Yields based on phenol and ammonia are >/= 96% and 80%, respectively. In the process phenol and fresh and recycle ammonia are vaporized separately (to prevent yield losses) and combined in the fixed bed amination reactor (a) containing the silica-alumina catalyst. After the reaction at 370 °C and 1.7 MPa, the gas is cooled, partly condensed and the excess ammonia is recovered in a separation column, compressed and recycled. The condensation product is passed through a drying column to remove water and then through a finishing column to separate aniline from residual phenol and impurities in vacuum (less than 80 kPa). The phenol, containing some aniline (azeotropic mixture) is recycled.

Manufactured from nitrobenzene or chlorobenzene.

Derivation: By (1) catalytic vapor-phase reduction of nitrobenzene with hydrogen; (2) reduction of nitrobenzene with iron filings using hydrochloric acid as catalyst; (3) catalytic reaction of chlorobenzene and aqueous ammonia; (4) ammonolysis of phenol (Japan).

Grades: Commercial; CP /chemically pure/

Aniline is available in the USA as a chemically pure grade (99.9% minimal purity) and as a technical grade (99.5% minimal purity).

Aniline oil

Blue oil

Cosmetics product ingredient: Aniline

Information on 1 consumer products that contain Aniline in the following categories is provided:

Rubber Product Manufacturing

Benzenamine: ACTIVE

First obtained in 1826 by Unverdorben from dry distillation of indigo. ... Fritzche, in 1841, prepared it from indigo and potash and gave it the name aniline.