기본 정보
- CAS
1154-25-2- 표준 SMILES
CCN(c1nc(N)c(C(=O)N=C(N)N)nc1Cl)C(C)C- InChIKey
QDERNBXNXJCIQK-UHFFFAOYSA-N- 분자식
- C11H18ClN7O
- 평균 분자량
- 299.76 g/mol
- 단동위원소 질량
- 299.1261359
개요
Ethylisopropylamiloride is a member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group. It has a role as an anti-arrhythmia drug, a sodium channel blocker and a neuroprotective agent. It is a member of guanidines, a monocarboxylic acid amide, an aromatic amine, an organochlorine compound, a member of pyrazines and a tertiary amino compound. It is functionally related to an amiloride.
이름 및 식별자
- 우선 이름
- Eipa
- IUPAC
- 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
- 영어명
- EIPA
- 분자식
- C11H18ClN7O
- 분자량
- 299.76
이름 및 동의어
EIPA1154-25-2Ethylisopropylamiloride5-(Ethylisopropyl)amilorideEthyl isopropyl amilorideDTXSID80151084VW50CE070T3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamideN-Amidino-3-amino-5-ethylisopropylamino-6-chloropyrazine carboxamide3-Amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)pyrazinecarboxamideMH-12-43CHEBI:136538
이름 더 보기
MH 12-43L 593754EIPA (L593754)EIPA, 10 mM in DMSOEthylisopropylamiloride (EIPA)AMILORIDE, 5-(N-ETHYL-N-ISOPROPYL)-Amiloride,5-(N-Ethyl-N-isopropyl)-[5-(N-Ethyl-N-isopropyl)amiloride
L-593754Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)-3-amino-6-chloro-N-(diaminomethylidene)-5-(ethyl(propan-2-yl)amino)pyrazine-2-carboxamideRefChem:596785DTXCID10735755-(N-Ethyl-N-isopropyl)amiloride5-(N-ethyl-N-isopropyl)-Amiloride3-Amino-N-carbamimidoyl-6-chloro-5-(ethyl(isopropyl)amino)pyrazine-2-carboxamide
물성
구조 계산 물성
- XLogP
- 1.3
- 극성 표면적
- 137 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 4
- 무거운 원자 수
- 20
- 형식 전하
- 0
- 복잡도
- 372
물리화학적 성질
- 녹는점
- 202 · 202-205 °C(lit.)
- 밀도
- 1.49 · 1.49±0.1 g/cm3(Predicted)
- 저장 조건
- 2 · Keep in dark place,Sealed in dry,2-8°C
- 용해도
- 아세토니트릴(약간 용해됨, 가열), DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 회백색 내지 황색 고체.
- 산도 계수 (pKa)
- 8.67 · 8.67±0.46(Predicted)
- 색상
- 연한 노란색에서 녹색까지
- 생물학적 소스
- synthetic
- 안정성
- 메탄올에서는 불안정함
- InChI
- InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
- InChIKey
- QDERNBXNXJCIQK-UHFFFAOYSA-N
- SMILES
- C1(C(NC(N)=N)=O)=NC(Cl)=C(N(CC)C(C)C)N=C1N
화학적 성질
Yellow Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
안전 데이터
- wgk
- 3
- ridadr
- 2811
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-37/39
- 포장분류
- III
- 위험 등급
- 6.1(b)
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
A subclass of sodium channel blockers that are specific for ACID-SENSING SODIUM CHANNELS.
A subclass of sodium channel blockers that are specific for EPITHELIAL SODIUM CHANNELS.
응용 분야
개요Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively. It less effectively inhibits NHE4 (IC50 ≥10 μM). EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.
공급사69 곳
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
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