2-(Trimethylsilyl)ethanol
2-(triMethylsilyl)ethan-1-ol · trimethylsilylethanol · Ethanol, 2-(trimethylsilyl)- · DK254 · DK717 · DKSI033 · 0.825 g/ML · DKFELEX0184
식별자 및 물리적 특성
| CAS No. | 2916-68-9 |
|---|---|
| 분자식 | C5H14OSi |
| 평균 분자량 | 118.25 g/mol |
| 단동위원소 질량 | 118.0813916 g/mol |
| SMILES | C[Si](C)(C)CCO |
| InChIKey | ZNGINKJHQQQORD-UHFFFAOYSA-N |
| PubChem CID | 18013 |
| ChEMBL | CHEMBL25482 |
| EC No. | 220-844-5 |
| DTXSID | DTXSID80183421 |
화학 및 물리적 성질
| 극성 표면적 | 20.2 |
|---|---|
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 1 |
| 회전 가능 결합 수 | 2 |
| 무거운 원자 수 | 7 |
| 형식 전하 | 0 |
| 복잡도 | 46.5 |
| SpringerMaterials Properties | 29Si nuclear magnetic resonance spectrum |
| 끓는 점 | 71-73 °C35 mm Hg(lit.) |
| 밀도 | 0.825 g/mL at 25 °C(lit.) |
| 굴절률 | n20/D 1.423(lit.) |
| 인화점 | 123 °F |
| 저장 조건 | Sealed in dry,2-8°C |
| 용해도 | 클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨) |
| pKa(산도 계수) | 15.38±0.10(Predicted) |
| 물리적 상태 | 액체 |
| 색상 | 무색의 |
| 비중 | 0.825 |
| 용해도 | 녹는 |
| BRN | 1732034 |
| 안정성 | 흡습성 |
| InChI | 1S/C5H14OSi/c1-7(2,3)5-4-6/h6H,4-5H2,1-3H3 |
| InChIKey | ZNGINKJHQQQORD-UHFFFAOYSA-N |
| SMILES | C[Si](C)(C)CCO |
| NIST | Trimethyl-2-hydroxyethylsilane(2916-68-9) |
화학적 성질
CLEAR COLOURLESS LIQUID
안전 및 규제
| GHS 분류 | WarningH226 (100%): Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 57 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | 2-(Trimethylsilyl)-ethanol: Does not have an individual approval but may be used under an appropriate group standard |
| Hazard Classes and Categories | Flam. Liq. 3 (100%) |
| 수질 위해 등급(WGK) | 3 |
| TSCA 등재 상태 | No |
| RTECS 번호 | KM5480000 |
| 운송 번호(UN) | UN 1987 3/PG 3 |
| 독성 | mouse,LD50,intraperitoneal,1122mg/kg (1122mg/kg),Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. Vol. 229, Pg. 1011, 1976. |
| 관세 코드 | 29310095 |
| 위험 문구(R) | 10-36/37/38 |
| 위험 표시 | Xi,F |
| 안전 문구(S) | 16-37/39-26-24/25 |
| 포장분류 | III |
| 위험 등급 | 3Flam. Liq. 3 |
| 위험 참고 사항 | Flammable |
| 저장 분류 | 3 - Flammable liquids |
용도
용도
2-(Trimethylsilyl)ethanol is a protecting reagent for carboxyl, phosphoryl, hydroxyl, and amino groups. It participates in the reactions of Phenol and Acid Protection, Alcohol Protection, Hemiacetal Protection, Amine Protection, Enol Ether Synthesis, Carbohydrate Chemistry etc.
제조 및 합성 방법
제조 방법
Three methods of preparation have been reported: (a) from the treatment of ethyl bromoacetate with zinc followed by the reaction with chlorotrimethylsilane1 and subsequent reduction of the resultant ethyl trimethylsilylacetate with lithium aluminum hydride2,3 or borane¨Ctetrahydrofuran(eq 1); (b) from the hydroboration/oxidation or oxymercuration/demercuration of vinyltrimethylsilane (eq 2); and (c)most conveniently, by the reaction of the Grignard reagent formed from (chloromethyl)trimethylsilane with paraformaldehyde (eq 3).