4.4.4-트리클로로부틸렌옥사이드

1,2-epoxy-4,4,4-trichlorobutane is a clear yellow liquid. (NTP, 1992)

Yellow liquid; [CAMEO]

Chemical: Oxirane, (2,2,2-trichloroethyl)-

S - indicates a substance that is identified in a final Significant New Use Rule.

Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Teratogenicity was evaluated in pregnant Charles River CD rats (25/group) orally exposed by gavage to trichlorobutylene oxide in Mazola corn oil vehicle at dose levels of 0, 10, 30, 100 or 300 mg/kg/day on gestation days (GD) 6-15. Cesarean sections were performed on GD 20. Significant differences were observed between treated and control animals in the following: increased maternal mortality (high-dose group, 14/25 died on GD 9-16), decreased weight and weight gain (high-dose group), and decreased fetal body weight (high-dose group). No significant differences were observed between treated and control animals in the following: mean number of viable or nonviable fetuses, early or late resorptions, postimplantation loss, total implantations, corpora lutea, fetal sex ratio, and number of fetuses or litters with fetal malformations.

The mutagenicity of trichlorobutylene oxide (TCBO) was evaluated in the bacteria Salmonella tester strains TA98, TA100, TA1535, TA1537 and TA1538 (Ames Test), and in the yeast Saccharomyces cerevisiae tester strain D3, both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on preliminary toxicity determinations, TCBO was tested for mutagenicity at concentrations up to 100 ul/desiccator (volume of desiccator not reported) using a desiccator assay method. TCBO caused a reproducible positive response in bacterial tester strains TA100, TA1535, and TA1537 without activation at concentrations of 25 ul/desiccator and higher and with activation in tester strains TA1535 at 10 ul/desiccator and higher and TA100 at 25 ul/desiccator and higher. TCBO did not cause a positive response in yeast tester strain D3, either with or without metabolic activation.

1,1,1-TRICHLOROBUTANE-3,4-OXIDE WAS A MODERATELY ACTIVE INHIBITOR OF EPOXIDE HYDRASE IN A SYSTEM USING CHICKEN LIVER MICROSOMES AND A RADIOMETRIC ASSAY BASED ON (3H)STYRENE OXIDE, AND USING PARTIALLY PURIFIED CHICKEN LIVER MICROSOMAL EPOXIDE HYDRASE AND A CONTINUOUS PHOTOMETRIC ASSAY BASED ON P-NITROSTYRENE OXIDE WITH HYDRATION MONITORED AT 310 NM. INHIBITION WAS GREATER AGAINST STYRENE OXIDE (KM= 1.0 MMOL) THAN AGAINST P-NITROSTYRENE OXIDE (KM= 4.2 MUMOL).

Used as a solvent and to make polymers and flame retardant resins; [HSDB]

CHEM INT FOR POLYMERS & FLAME RETARDANT RESINS

SOLVENT

(1979) No Data

(1981) No Data

(1979) No Data

(1981) No Data

(1977) AT LEAST 4.54X10+8 G (CAPTIVE PRODN)

(1981) No Data