기본 정보
- CAS
3092-17-9- 표준 SMILES
COc1ccc(OC)c(C(O)CNC(=O)CN)c1.Cl- InChIKey
MGCQZNBCJBRZDT-UHFFFAOYSA-N- 분자식
- C12H19ClN2O4
- 평균 분자량
- 290.74 g/mol
- 단동위원소 질량
- 290.1033348
개요
Midodrine hydrochloride is a hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. The hydrochloride salt is used as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. It has a role as a sympathomimetic agent, an alpha-adrenergic agonist and a vasoconstrictor agent. It contains a midodrine(1+).
이름 및 식별자
- 우선 이름
- Midodrine Hydrochloride
- IUPAC
- 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide;hydrochloride
- 현지명
- 미도드린하이드로클로라이드
- 영어명
- Midodrine hydrochloride
- 분자식
- C12H19ClN2O4
- 분자량
- 290.74
이름 및 동의어
MIDODRINE HYDROCHLORIDE43218-56-0Midodrine HCLPro-AmatineProAmatineHipertanAmatineOrvatenGutronMidamineSt. Peter 224(+-)-Midodrine hydrochloride
이름 더 보기
미도드린하이드로클로라이드MIDODRINEST-1085Prestwick_625
MetligineMidodrine MonohydrochlorideA-4020 LinzDTXSID104749359JV96YTXVST-PETER-224NSC-758429ST1085 HYDROCHLORIDE
데이터베이스 식별자
- CAS
3092-17-9、43218-56-0- PubChem CID
- 18340
- DTXSID
DTXSID1047493- ChEMBL
CHEMBL1200461- ChEBI
CHEBI:31847- UNII
- 59JV96YTXV
- EC Number
- 256-148-3、622-590-4
물성
구조 계산 물성
- 극성 표면적
- 93.8 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 19
- 형식 전하
- 0
- 복잡도
- 262
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section154 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
물리화학적 성질
- 녹는점
- 192 · 192-193°C
- 저장 조건
- -20 °C · -20°C Freezer
- 주요 응용
- 법의학 및 독성학의약품(소분자)수의사
- InChI
- InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H
- InChIKey
- MGCQZNBCJBRZDT-UHFFFAOYSA-N
- SMILES
- C1(C(O)CNC(=O)CN)C=C(C=CC=1OC)OC.Cl
화학적 성질
Crystalline Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H301 (97.6%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 2 notifications to the ECHA C&L Inventory.
Danger
H301 (66.7%): Toxic if swallowed [Danger Acute toxicity, oral]
유해성 정보
Hazard Classes and Categories
Acute Tox. 3 (66.7%)
Acute Tox. 3 (97.6%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Midodrine hydrochloride
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
안전 데이터
- wgk
- 3
- rtecs
- AB4343000
- ridadr
- UN 2811 6.1/PG 3
- HS 번호
- 29242990
- risk_code
- 25
- hazard_code
- T
- safety_code
- 45
- Hazard Classifications
- Acute Tox. 3 Oral
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
화학 및 산업
약리 정보
FDA Pharmacological Classification
MIDODRINE HYDROCHLORIDE
alpha-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]
MeSH Pharmacological Classification
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Drugs used to cause constriction of the blood vessels.
Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS.
응용 분야
용도A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects
일반 설명Midodrine is the N-glycyl prodrug ofthe selectiveα1-agonist desglymidodrine. Removal of theN-glycyl moiety from midodrine occurs readily in the liver aswell as throughout the body, presumably by amidases.Midodrine is orally active and represents another example ofa dimethoxy-β-phenylethylamine derivative that is used therapeuticallyfor its vasoconstrictor properties. Specifically, it isused in the treatment of symptomatic orthostatic hypotension.
상·하류 제품 정보
상류 원료
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4건
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