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HCID 18529생성일: 2026년 10월 27일

헥사브로모사이클로도데케인(헥사브로모사이클로도데칸)

헥사브로모사이클로도데칸 · 헥사브로모사이클로도데케인(헥사브로모사이클로도데칸) · 헥사브로모시클로도데칸 · 1,2,5,6,9,10-헥사브로모사이클로도데케인 · 사이클로도데케인, 1,2,5,6,9,10-헥사브로모- · HBCD · ALPHA-HEXABROMOCYCLODODECANE · SAYTEX HP-900

https://huagongshe.com/ko/chemical/18529

헥사브로모사이클로도데케인(헥사브로모사이클로도데칸) 분자 구조식

식별자 및 물리적 특성

CAS No.3194-55-6
분자식C12H18Br6
평균 분자량641.7 g/mol
단동위원소 질량635.65088 g/mol
SMILESBrC1CCC(Br)C(Br)CCC(Br)C(Br)CCC1Br
InChIKeyDEIGXXQKDWULML-UHFFFAOYSA-N
PubChem CID18529
ChEMBLCHEMBL375298
ChEBICHEBI:134063
EC No.221-695-9
DTXSIDDTXSID4027527
현지명헥사브로모사이클로도데케인(헥사브로모사이클로도데칸)

화학 및 물리적 성질

XLogP7.1
극성 표면적0
수소 결합 공여자 수0
수소 결합 수용자 수0
회전 가능 결합 수0
무거운 원자 수18
형식 전하0
복잡도175
농약Pesticide -> EPA IRIS
PlasticizersPlastics & Rubber -> Other Plasticizers
Flame RetardantsNovel flame retardant
Endocrine DisruptorsPotential endocrine disrupting compound
증기압0.00000047 [mmHg]
Physical DescriptionSolid[HSDB] Beige powder[MSDSonline]
Stability/Shelf LifeStable under recommended storage conditions.
Collision Cross Section185.8 Ų [M-H]- [CCS Type: DTBuffer gas: N2Ionization: ESI-Dataset: TOXCASTSource Identifier: DTXSID4027527]
녹는점188-191 °C
끓는 점505.2±50.0 °C(Predicted)
밀도2.145±0.06 g/cm3(Predicted)
용해도아세톤: 가용성 25mg/mL, 투명, 무색~연황색
BRN1911324
헨리 상수2.1×10-1 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
InChIInChI=1S/C12H18Br6/c13-7-1-2-8(14)10(16)5-6-12(18)11(17)4-3-9(7)15/h7-12H,1-6H2
InChIKeyDEIGXXQKDWULML-UHFFFAOYSA-N
SMILESC1(Br)CCC(Br)C(Br)CCC(Br)C(Br)CCC1Br
EPA1,2,5,6,9,10-Hexabromocyclododecane (3194-55-6)

화학적 성질

off-white to beige crystalline powder and chunks

안전 및 규제

GHS 분류WarningH361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]P203, P260, P263, P264, P270, P280, P318, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.8% (3 of 367) of reports.H315 (17.4%): Causes skin irritation [Warning Skin corrosion/irritation]
규제 정보Chemical: Cyclododecane, 1,2,5,6,9,10-hexabromo-Hazard Traits - BioaccumulationEndocrine ToxicityEnvironmental PersistenceNeurotoxicityReproductive ToxicityS - indicates a substance that is identified in a final Significant New Use Rule.Substance: 1,2,5,6,9,10-hexabromocyclododecane
기타 안전 정보PEC / SN / Other assessments - Hexabromocyclododecane (HBCD): Health and Environment
유해성 요약An estimated 100 to 999 workers are exposed to this chemical during manufacturing, processing, and use in the US. The product used in animal testing was hexabromocyclododecane (mixed isomers), also called Firemaster 100. There were no deaths after a 24-hour application to 20-30% of the body surface area, so the dermal LD50 (rabbit) was >20 gm/kg. The same chemical was used in the inhalation study, and the animals exhibited slight dyspnea, but no deaths, after 4-hour exposures to visibly dusty conditions. The LC50 (rats) was >202 mg/L/4h. Testing for eye irritation was negative. [HSDB] May cause irritation[MSDSonline]
Special ReportsLaw RJ et al.Hexabromocyclododecane Challenges Scientists and Regulators. ENVIRONMENTAL SCIENCE & TECHNOLOGY 281A -287A (2005). This paper describes possible HBCD stereoisomers and related scientific and regulatory challenges.[Law RJ et al.ENVIRONMENTAL SCIENCE & TECHNOLOGY 281A -287A (2005)Available from, as of March 6, 2015: http://www.novaquatis.eawag.ch/media/20050725/2507_artikel_science_techn.pdf]European Commission, ESISRisk Assessment: Hexabromocyclododecane (25637-99-4) (May 2008).[Available from, as of March 3, 2009: http://esis.jrc.ec.europa.eu/]
TSCA 요건Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 1/11/90

용도

용도

1,2,5,6,9,10-Hexabromocyclododecane(HBCD) was used to compare the efficiency of different advanced extraction techniques for the recovery of brominated flame retardants from styrenic polymers. It was used to study the kinetics of the thermal and photolytic segregation of HBCD using HPLC.

일반 설명

1,2,5,6,9,10-Hexabromocyclododecane(HBCD) is a brominated flame retardant. It is used in the textile industry and polystyrene foam manufacturing. Electrochemical reduction of HBCD at carbon and silver cathodes has been studied using cyclic voltammetry and controlled-potential electrolysis.

Reporting date: 3/12/90.
Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Hexabromocyclododecane is included on this list. Effective date 1/11/90
Sunset date: 12/19/95.
Toxic Combustion ProductsCarbon oxides, Hydrogen bromide gas
Hazard Classes and CategoriesSkin Irrit. 2 (17.4%)Reproductive toxicity - category 2Repr. 2
Hazardous Reactivities and IncompatibilitiesStrong oxidizing agents
소화 절차Wear self contained breathing apparatus for fire fighting if necessary.Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
보관 조건Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
정리 방법ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust. For personal protection see section Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. 6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
처리 방법SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product.
Preventive MeasuresHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Personal Protective Equipment (PPE)Skin protection: Handle with gloves.Eye/face protection: Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Control of environmental exposure: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Respiratory protection: For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator. For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).Body Protection: Impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
상호 작용Thyroid hormone (TH) plays an essential role in growth and differentiation of the central nervous system. Deficiency of TH during perinatal period results in abnormal brain development known as cretinism in human. We recently reported that an environmental chemical 1,2,5,6,9,10-a-hexabromocyclododecane (HBCD) suppressed TH receptor (TR)-mediated transcription. To examine the effect of HBCD on cerebellar granule cells, we used purified rat cerebellar granule cells in reaggregate culture. Low dose HBCD (10(-10)M) significantly suppressed TH-induced neurite extension of granule cell aggregate. To clarify further the mechanisms of such suppression, we added brain-derived neurotrophic factor (BDNF) into culture medium, since BDNF plays a critical role in promoting granule cell development and is regulated by TH. BDNF completely rescued HBCD-induced suppression of granule cell neurite extension in the presence of T3. These results indicate that HBCD may disrupt TH-mediated brain development at least in part due to a disruption of the T3 stimulated increase in BDNF and BDNF may possess ability to ameliorate the effect of HBCD in granule cells.
생태독성 수치EC50Species: Lepomis macrochirus, Rafinesque (Bluegill sunfish)Conditions: staticConcentration: >100 mg/L for 96 hr (nominal concentration)Effect: no abnormal behavior was observed in any of the concentrations testedSpecies: Daphnia magna (Water flea)Conditions: static, 20 °CConcentration: 146 mg/L for 48 hr (95% confidence limit: 146.25-146.43 mg/L)Effect: mortlaity, immobility /Hexabromid S, purity about 92%)/Species: Scenedesmus subspicatus (algae)Concentration: >500 mg/L for 96 hrEffect: growth inhibition, biomass /Conditions of bioassay not specified in source examined/ /Hexabromid S/
독성 요약IDENTIFICATION AND USE: HBCD technical grade consists of a mixture of isomers, predominantly the alpha-, beta, and gamma-enantiomeric pairs. The main use for HBCD is as an additive-type flame retardant for extruded and expanded polystyrene foam. Other applications include crystal and high-impact polystyrene, SAN (Styrene-AcryloNitrile) resins, adhesives, and coatings. HUMAN EXPOSURE AND TOXICITY: Human data not found. ANIMAL STUDIES: The chemical was not an eye irritant in rabbits, ant it minimally irritating to the skin of rabbits. In acute oral toxicity study in rats the following non-lethal toxicity signs were observed during the 14-day observation time. Females: diarrhea in 1 of 5, hypoactivity in 1 of 5. Males: hypoactivity in 3 of 5, corneal opacity in 3 of 5 and ptosis in 3 of 5. None of the animals died. In inhalation study 90 minutes after initiation of exposure to the end of the 4 hours exposure period the rats exhibited slight dyspnea. In developmental study in rats HBCD exerted a weak hypothyroidism evident with increases in thyroid weight, thyroid follicular cell hypertrophy and serum concentrations of thyroid-stimulating hormone as well as decreases of serum T(3) concentrations in offspring at 10,000 ppm at weaning. Increased thyroid weights and decreased serum T(3) concentrations were also observed in the adult stage from 1000 ppm. With regard to the effect on brain development, HBCD reduced density of CNPase-positive oligodendrocytes at 10,000 ppm, suggesting an impaired oligodendroglial development. Low-dose HBCD can potentially disrupt thyroid hormone-mediated transactivation and impairs Purkinje cell dendritogenesis, suggesting that HBCD can interfere with thyyroid hormone action in target organs, including the developing brain.
Ongoing Test StatusEPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assaysClick on the "Chemical Explorer" button on the tool bar to see the data./[USEPAICSS Dashboard ApplicationAvailable from, as of December 8, 2014: http://actor.epa.gov/dashboard/]
EPA IRIS InformationHexabromocyclododecane (HBCD)
Non-Human Toxicity Excerpts/LABORATORY ANIMALS: Acute Exposure/ In an acute dermal toxicity study 2 male and 2 female New Zealand White rabbits were used. The hair was removed from the back (20-30% of the body surface). HBCDD (a white powder identified as "Firemaster 100") was applied once at a dosage level of 20 g/kg. The area of application was bandaged and occluded. The bandages were removed 24 hours later and the backs were washed. The animals were observed daily thereafter for a total of 14 days. None of the animals died. There is no information if any nonlethal signs of toxicity appeared. Minimal lethal dose by dermal route is thus greater than 20 g/kg. The study was not performed according to current guidelines. /Firemaster 100//LABORATORY ANIMALS: Acute Exposure/ In an acute oral toxicity study of HBCDD, 5 male and 5 female rats (Charles River CD strain) were used. The test material (a white powder identified as "Firemaster 100") was suspended in corn oil (particle size unknown) and administered orally by gavage at a dosage level of 10 g/kg in a volume of 20 mL/kg. The rats were observed for mortality and toxic signs during the first four hours after dosing, at 24 hours and then daily for 14 days. The following non-lethal toxicity signs were observed during the 14-day observation time. Females: diarrhea in 1 of 5, hypoactivity in 1 of 5. Males: hypoactivity in 3 of 5, corneal opacity in 3 of 5 and ptosis in 3 of 5. None of the animals died. Minimum lethal dose by oral dosing is then greater than 10 g/kg. The study was similar to the OECD guideline limit test. /Firemaster 100//LABORATORY ANIMALS: Acute Exposure/ Five Charles River CD rats of each sex were used in an acute inhalation toxicity study. The animals were whole body exposed to a dust of HBCDD (a white powder identified as "Firemaster 100", unknown particle size) at a concentration of 202 mg/L for 4 hours. The authors noted, "the chamber atmosphere was extremely dusty". The immediate (first 10 minutes) response to the dusty atmosphere was an increase of activity in preening. 90 minutes after initiation of exposure to the end of the 4 hours exposure period the rats exhibited slight dyspnea. During the 14 days observation period the animals appeared normal. No deaths occurred. The study was not performed according to current guidelines. /Firemaster 100//LABORATORY ANIMALS: Acute Exposure/ Three male and 3 female New Zealand White rabbits were used for an eye irritation study. The eyes of the rabbits (weight 2003 to 2220 g) were examined with ultraviolet light following instillation of a sodium fluorescein solution. The rabbits received 100 mg of HBCDD ("Firemaster 100") placed into the cupped conjunctival sac of the right eye, then the eyelids were gently held together for one second. The left eye served as the untreated control for each rabbit. The eyes were examined 24, 48, 72 hours and 7 days following instillation. The scores for iris and cornea were zero so the results refer to the effects on conjunctiva. The group average scores 0.6, 1.0, 1.0, and 0 respectively at the different time points. The total maximum score possible was 110. Based on the scores obtained it was concluded that the test material is not a primary eye irritant and according to EU criteria it does not classify as an eye irritant. /Firemaster 100/For more Non-Human Toxicity Excerpts (Complete) data for 1,2,5,6,9,10-HEXABROMOCYCLODODECANE (7 total), please visit the HSDB record page.
Antidote and Emergency Treatment/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Halogenated aliphatic hydrocarbons and related compounds//SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with sterile dressings after decontamination ... . /Halogenated aliphatic hydrocarbons and related compounds//SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of cardiac irritability and fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Halogenated aliphatic hydrocarbons and related compounds/
Toxicity DataLC50 (rat) > 202 mg/L/4h
Non-Human Toxicity ValuesLD50 Rat oral > 10,000 mg/kg. /Firemaster 100/LC50 Rat inhalation > 202 mg/L for 4 hours. /Firemaster 100/LD50 Rabbit dermal > 20,000m g/kg. /Firemaster 100/
수질 위해 등급(WGK)1
TSCA 등재 상태TSCA listed
RTECS 번호GU2302500
운송 번호(UN)3077
관세 코드29038900
위험 문구(R)36/37/38-64-50/53-63
위험 표시Xi,N,Xn
안전 문구(S)22-24/25-61-60-36/37-53
기존화학 물질KE-18398
F 고인화성물질3-9
위험 등급Aquatic Acute 1Aquatic Chronic 1Lact.Repr. 2
저장 분류11 - Combustible Solids
유해 물질 데이터3194-55-6(Hazardous Substances Data)
중점관리물질 필터링별표1-118