6(5H)-Phenanthridinone (HCID 1853)

이름 및 식별자

우선 이름: 6(5H)-Phenanthridinone
IUPAC: 5H-phenanthridin-6-one
영어명: 6(5H)-Phenanthridone
분자식: C13H9NO
분자량: 195.22

이름 및 동의어

6(5H)-Phenanthridinone1015-89-0Phenanthridin-6(5H)-onePhenanthridone6-Phenanthridinol6-Phenanthridinone6-PhenanthridonePhenantridoneAVQ13AUB5JNSC-11021NSC-40943NSC-61083

이름 더 보기

PHENANTHRIDINONE6(5H)-PhenantridinonePJ 97ANSC 11021NSC 40943NSC 61083WD 99-004344

DTXSID0074423CHEBI:75292RefChem:860541DTXCID1032640213-804-35H-phenanthridin-6-one6-(5H)-phenanthridinonephenanthridin-6-ol

데이터베이스 식별자

CAS: 1015-89-0
PubChem CID: 1853
DTXSID: DTXSID0074423
ChEMBL: CHEMBL45245
ChEBI: CHEBI:75292
UNII: AVQ13AUB5J
EC Number: 213-804-3
Nikkaji: J69.574B

물성

구조 계산 물성

XLogP: 2.5
극성 표면적: 29.1 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 1
회전 가능 결합 수: 0
무거운 원자 수: 15
형식 전하: 0
복잡도: 263

실험 및 물리화학적 성질

Physical DescriptionPowder; [Alfa Aesar MSDS]

물리화학적 성질

녹는점: 290 · 290-292 °C(lit.)
끓는 점: 435 °C · 435 °C
밀도: 1.23 · 1.230±0.06 g/cm3(Predicted)
저장 조건: Sealed in dry,Room Temperature
용해도: 1 mg/mL; · DMF: 1mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16mg/mL
산도 계수 (pKa): 13.27 · 13.27±0.20(Predicted)
물리적 상태: powder to crystal
색상: White to Light yellow to Light orange
수용성: DMSO(5 mg/ml)에 용해됩니다. 물에 불용성.
BRN: 140641 · 140641
InChI: InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
InChIKey: RZFVLEJOHSLEFR-UHFFFAOYSA-N
SMILES: C1=C2C(NC(=O)C3=C2C=CC=C3)=CC=C1
NIST: 6 · 6(5H)-phenanthridinone(1015-89-0)
EPA: 6 · 6-Phenanthridinone (1015-89-0)

안전 및 규제

GHS 분류

GHS Classification · 5건

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

유해성 정보

Hazards SummaryMay cause irritation; [Alfa Aesar MSDS] See POLYCYCLIC AROMATIC HYDROCARBONS.

Hazard Classes and CategoriesSkin Irrit. 2 (100%)；Eye Irrit. 2A (100%)；STOT SE 3 (100%)

안전 데이터

wgk: 3
rtecs: SG0370000
HS 번호: 29337900
safety_code: 22-24/25
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

약리 정보

MeSH Pharmacological ClassificationChemicals and drugs that inhibit the action of POLY(ADP-RIBOSE)POLYMERASES.

용도 및 제조

UsesA coal tar derivative; [ChemIDplus]

응용 분야 · 2건

용도6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation.

일반 설명6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.

상·하류 제품 정보

상류 원료

1,3-bis(2-phenylphenyl)urea 2-아미노바이페닐(2-AMINOBIPHENYL)N-(2-비페닐릴)-p-톨루엔술폰아미드 2-요오도비페닐-2'-아민 N-methoxy-[1,1'-biphenyl]-2-carboxamide 2-브로모-N-페닐벤즈아미드 베노다닐 9-플루오레논옥심 [1,1'-비페닐]-2-카르복스아미드 carbon monoxide 아세트아닐리드 9-플루오레논

하류 제품

2-니트로-6(5H)-페난트리디논

공급사50 곳

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]

武汉欣扬瑞和化学科技有限公司153-07155313 15307155313 · [email protected]

常熟市海天医药原料有限公司13913622609

추가 설명

정의ChEBI: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.

연결된 노트

불러오는 중…

6(5H)-Phenanthridinone

기본 정보