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기본 정보
- CAS
130717-51-0- 표준 SMILES
COc1ccc(-c2nc(C(=O)N3CCN(C)CC3)sc2-c2ccc(OC)cc2)cc1.Cl- InChIKey
YWMAVHIKOAOSFM-UHFFFAOYSA-N- 분자식
- C23H26ClN3O3S
- 평균 분자량
- 459.999 g/mol
- 단동위원소 질량
- 459.13834037
이름 및 식별자
- 우선 이름
- [4,5-Bis(4-methoxyphenyl)-1,3-thiazol-2-yl](4-methylpiperazin-1-yl)methanone--hydrogen chloride (1/1)
- IUPAC
- [4,5-Bis(4-methoxyphenyl)-1,3-thiazol-2-yl](4-methylpiperazin-1-yl)methanone--hydrogen chloride (1/1)
- 현지명
- FR122047염산염
- 영어명
- FR 122047 hydrochloride
- 분자식
- C23H26ClN3O3S
- 분자량
- 459.99
이름 및 동의어
FR122047염산염FR 122047FR122047HClFR 122047 hydrochlorideCOX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole(4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE
데이터베이스 식별자
- CAS
130717-51-0- PubChem CID
- 196840
- DTXSID
DTXSID90926866- ChEMBL
CHEMBL5483052
물성
물리화학적 성질
- 저장 조건
- 2 · 2-8°C
- 용해도
- 50 mg/m， · 염화메틸렌: 50 mg/m， 약간 흐릿함, 노란색
- 물리적 상태
- 가루
- 색상
- 희미한 노란색
- 생물학적 소스
- synthetic (organic)
- 수용성
- 10 mM · Soluble to 10 mM in water
- InChI
- 1S/C23H25N3O3S.ClH/c1-25-12-14-26(15-13-25)23(27)22-24-20(16-4-8-18(28-2)9-5-16)21(30-22)17-6-10-19(29-3)11-7-17;/h4-11H,12-15H2,1-3H3;1H
- InChIKey
- YWMAVHIKOAOSFM-UHFFFAOYSA-N
- SMILES
- Cl[H].COc1ccc(cc1)-c2nc(sc2-c3ccc(OC)cc3)C(=O)N4CCN(C)CC4
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- safety_code
- 22-24/25
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.
용도FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.
공급사21 곳
Aladdin Scientific[email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
杭州辅润医药科技有限公司15658004993 · [email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
上海相辉医药科技有限公司13761987713; 13761987713 · [email protected]
广州爱纯医药科技有限公司020-39119399 18927568969 · [email protected]
杭州六可生物科技有限公司+86-0571-86912261 +86-15658003402 · [email protected]
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