기본 정보
- CAS
129496-10-2- 표준 SMILES
CC1=C[C@H]2C(=O)O[C@H]3C[C@@H](C/C=C(\C)C[C@@H](C)/C=C/C=C4\CO[C@H](/C1=N\O)[C@@]42O)O[C@@]1(CC[C@H](C)[C@@H](C)O1)C3.CC[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)C[C@@H](C)/C=C/C=C3\CO[C@@H]4/C(=N\O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2- InChIKey
LKMMLHTWKLEARD-MGZQXKBQSA-N- 분자식
- C63H88N2O14
- 평균 분자량
- 1,097.4 g/mol
- 단동위원소 질량
- 1,096.62355549
개요
used for heartworm (Dirofilaria immitis) and mites in dogs
이름 및 식별자
- 우선 이름
- Milbemycin, oxime
- IUPAC
- (1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,21Z,24S)-6'-ethyl-24-hydroxy-21-hydroxyimino-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one;(1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,21Z,24S)-24-hydroxy-21-hydroxyimino-5',6',11,13,22-pentamethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
- 영어명
- Milbemycin oxime
- 분자식
- 2C32H45NO7.2C31H43NO7
- 분자량
- 2194.78
이름 및 동의어
Milbemycin oximeInterceptor flavor tabsMilbemiteMilbeGuardCGA-1792460502PUN0GTMilbemite Otic SolutionMILBEGUARD FLAVOREDTRIFEXIS COMPONENT MILBEMYCIN OXIMENEXGARD SPECTRA COMPONENT MILBEMYCIN OXIMERefChem:66538DTXCID40819951
이름 더 보기
MilbeximeMibemycin oximeMilbemyein oximeMilbemycin oxime CRSβ-phenylacrylophenoneMilbemycin oxime 92~95%Milbemycin Oxime (200 mg)Milbemycin Oxime (1443806)
DTXSID501057491129496-10-2DTXSID4058495Milbemycin, oximeMilbemycin A, 5-oximeSentinel flavor tabsUNII-0502PUN0GTMilbemycin oxime (Standard)
데이터베이스 식별자
- CAS
129496-10-2
물성
구조 계산 물성
- 극성 표면적
- 214 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 16
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 79
- 형식 전하
- 0
- 복잡도
- 2,260
실험 및 물리화학적 성질
Animal DrugsFDA approved animal drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 169.6 · 169.6-177.4°
- 인화점
- 412 ℃ · 412℃
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 100 · DMSO:100.0(Max Conc. mg/mL);91.13(Max Conc. mM)
- 물리적 상태
- 결정성 고체
- 색상
- White to off-white
- 안정성
- 흡습성
- 주요 응용
- 의약품(소분자)
- InChIKey
- LKMMLHTWKLEARD-MGZQXKBQSA-N
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 2.4% (1 of 41) of reports.
Danger
H302 (92.7%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P261, P264, P270, P271, P273, P301+P317, P304+P340, P317, P319, P330, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory InformationMilbemycin oxime: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (92.7%)
안전 데이터
- wgk
- 3
- ridadr
- 2588
- 독성
- LD50 orally in mice: 1000-1500 mg/kg (Ciba-Geigy)
- HS 번호
- 2932206000
- 포장분류
- III
- 위험 등급
- 6.1(b)
- Hazard Classifications
- Aquatic Acute 1Aquatic Chronic 1
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
ATC CodeQP - Antiparasitic products, insecticides and repellents
MeSH Pharmacological ClassificationAgents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
응용 분야
용도Milbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of two natural products, milbemycin A3 and A4 (in ~30:70 ratio). Milbemycin oxime is used therapeutically for the prevention of intestinal parasites in dogs. Like the other milbemycin/avermectins, it was developed for intestinal parasite control in animals and acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.
상·하류 제품 정보
상류 원료
공급사100 곳
国药集团化学试剂有限公司86-21-63210123 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
苏州法姆医药科技有限公司0510-88771160 18051901298 · [email protected]
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