Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Levopropoxyphene
HSDB 3414 · l-Propoxyphene · Levopropossifene · levopropoxyphene · Levopropoxyphenum · levopropoxyphene USP/EP/BP · (1R,2S)-1-benzyl-3-dimethylamino-2-methyl-1-phenylpropyl propionate · (1R,2S)-3-(Dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)propyl propanoate
식별자 및 물리적 특성
| CAS No. | 2338-37-6 |
|---|---|
| 분자식 | C22H29NO2 |
| 평균 분자량 | 339.5 g/mol |
| 단동위원소 질량 | 339.21982917 g/mol |
| SMILES | CCC(=O)O[C@@](Cc1ccccc1)(c1ccccc1)[C@@H](C)CN(C)C |
| InChIKey | XLMALTXPSGQGBX-PGRDOPGGSA-N |
| PubChem CID | 200742 |
| ChEMBL | CHEMBL1738990 |
| ChEBI | CHEBI:51174 |
| DTXSID | DTXSID8023212 |
화학 및 물리적 성질
| XLogP | 4.2 |
|---|---|
| 극성 표면적 | 29.5 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 9 |
| 무거운 원자 수 | 25 |
| 형식 전하 | 0 |
| 복잡도 | 397 |
| 의약품 | Pharmaceuticals -> Listed in ZINC15 |
| LogP(분배 계수) | 4.81 |
| Color/Form | CRYSTALS FROM PETROLEUM ETHER |
| 용해도 | SOL IN METHANOL, ALC, CHLOROFORM, & ACETONEVERY SOL IN WATER /NAPSYLATE/ |
| 녹는점 | 75-76ºC75-76 °CMP: 163-164 °CSPECIFIC OPTICAL ROTATION: -60.1 DEG @ 25 °C/D (0.7%)/HYDROCHLORIDE/75-76° |
| Optical Rotation | SPECIFIC OPTICAL ROTATION: -68.2 DEG @ 25 °C/D (CHLOROFORM, 0.6%) |
| Stability/Shelf Life | PERMITS MORE STABLE LIQ & TABLET DOSAGE FORMS /NAPSYLATE/ |
| Other Experimental Properties | ESSENTIALLY ODORLESS & HAS BITTER TASTEMELTS WITHIN RANGE OF 4 DEG BETWEEN 158 & 165 °C /NAPSYLATE/CRYSTALS FROM METHANOL PLUS ETHYL ACETATE /HYDROCHLORIDE/WHITE POWDER /NAPSYLATE/ |
| 끓는 점 | 444.0±45.0 °C(Predicted) |
| 밀도 | 1.038±0.06 g/cm3(Predicted) |
| pKa(산도 계수) | 9.19±0.28(Predicted) |
안전 및 규제
| 상호 작용 | THE ANALGESIA PRODUCED BY ORAL ADMIN OF D-PROPOXYPHENE IS ENHANCED BY INITIAL LOADING WITH L-PROPOXYPHENE. |
|---|---|
| Human Toxicity Excerpts | UNTOWARD EFFECTS ARE USUALLY MILDHEADACHE, LIGHT-HEADINESS, SKIN RASH, DRYNESS OF MOUTH, NAUSEA & VOMITING, URINARY URGENCY, & TREMORS HAVE BEEN REPORTED. /NAPSYLATE/SIDE EFFECTS OF LEVOPROPOXYPHENE INCL...URTICARIA, DROWSINESS...& DIZZINESS. /NAPSYLATE/ |
| Non-Human Toxicity Excerpts | L-PROPOXYPHENE-HCL (225 MG/KG, SC) DECREASED NORADRENALINE LEVELS IN BRAINS OF MICE. |
| 유해 물질 데이터 | 2338-37-6(Hazardous Substances Data) |
용도
용도
Antitussive.