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HCID 2083생성일: 2026년 10월 27일

살부타몰

살부타몰 · 알부테롤 · Albuterol · ventolin · LEVALBUTEROL HCL · proventil · Volmax · aerolin

https://huagongshe.com/ko/chemical/2083

살부타몰 분자 구조식

식별자 및 물리적 특성

CAS No.18559-94-9
분자식C13H21NO3
평균 분자량239.31 g/mol
단동위원소 질량239.15214353 g/mol
SMILESCC(C)(C)NCC(O)c1ccc(O)c(CO)c1
InChIKeyNDAUXUAQIAJITI-UHFFFAOYSA-N
PubChem CID2083
ChEMBLCHEMBL714
ChEBICHEBI:2549
EC No.242-424-0
DTXSIDDTXSID5021255
현지명살부타몰

화학 및 물리적 성질

XLogP0.3
극성 표면적72.7
수소 결합 공여자 수4
수소 결합 수용자 수4
회전 가능 결합 수5
무거운 원자 수17
형식 전하0
복잡도227
물질 분류Pharmaceutical
의약품Pharmaceuticals
LogP(분배 계수)log Kow = 0.64 /Estimated/1.4
Color/FormWhite to off-white crystalline solidCrystalline powder from ethanol-ethyl acetate or ethyl acetate-cyclohexane
용해도Soluble in ethanol, sparingly soluble in water, and very soluble in chlorform.Soluble in most organic solvents.In water, 1.43X10+4 mg/L, temp not specified2.15e+00 g/L물에 거의 녹지 않으며, 에탄올(96%)에 녹습니다.
Human DrugsBreast FeedingLactationMilk, HumanAnti-Asthmatic AgentsBronchodilator AgentsBeta Adrenergic AgonistsFDA approved drugs -> Active ingredientPharmaceuticalsAntiasthmatic and medicines for chronic obstructive pulmonary disease
녹는점147-149151 °C (Lunts)157-158 °C (Collins)157 - 158 °C157-160℃
증기압8.9X10-9 mm Hg at 25 °C /Estimated/
Optical RotationMW: 275.58. Crystallized as the monohydratechanges crystalline form at 175 °Cdecopmoses 188-195 °C. Specific optical rotation: -32.2 deg @ 20 °C/D (c = 0.1 in water) /(R)-form hydrochloride/
헨리 상수Henry's Law constant = 6.4X10-16 atm-cu m/mole at 25 °C /Estimated/1.5×1010 mol/(m3Pa) at 25℃, HSDB (2015)
Physical DescriptionSolid
Dissociation Constants10.3pKa1 = 9.2 (amine nitrogen)pKa2 = 10.7 (phenolic -OH) /Estimated/
끓는 점381.97°C (rough estimate)
밀도1.0700 (rough estimate)
굴절률1.4800 (estimate)
저장 조건2-8°C
pKa(산도 계수)pKa 9.07(H2O t = 25.0±0.05 I = 0.10) (Uncertain)10.37(H2O t = 25.0±0.05 I = 0.10) (Uncertain)
물리적 상태Solid
색상하얀색
용해도17.95g/L(25℃)
Merck13,215
BRN6405698
BCS Class3
안정성안정적이지만 빛에 민감합니다. 강한 산화제와 호환되지 않습니다.
주요 응용임상 시험
InChI1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
InChIKeyNDAUXUAQIAJITI-UHFFFAOYSA-N
SMILESCC(C)(C)NCC(O)c1ccc(O)c(CO)c1
LogP(분배 계수)0.64
EPA1,3-Benzenedimethanol, .alpha.1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy- (18559-94-9)

화학적 성질

solid

안전 및 규제

GHS 분류WarningH302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P270, P272, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 51 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
규제 정보Status: Active Update: 28-11-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/215481,3-Benzenedimethanol, .alpha.1-(1,1-dimethylethyl)aminomethyl-4-hydroxy-: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보IMAP assessments - 1,3-Benzenedimethanol, .alpha.1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-: Environment tier I assessment
FDA 요건The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl albuterol, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl albuterol sulfate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Albuterol Sulfate/Certain other dosage form new animal drugs. Albuterol. Indications for use: for the immediate relief of bronchospasm and bronchoconstriction associated with reversible airway obstruction in horses. Limitations: Not for use in horses intended for food.
Hazard Classes and CategoriesAcute Tox. 4 (98%)
보관 조건Albuterol sulfate tablets, extended-release tablets, and the oral solution should be stored at 2-30 °C, unit-dose packages of the extended-release tablets should be protected from excessive moisture. /Albuterol sulfate/Preparations containing albuterol or albuterol sulfate should be stored in well-closed, light resistant containers. Commercially available metered-dose albuterol and albuterol sulfate inhalers should be stored at 15-30 adn 15-25 °C, respectively.
처리 방법SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality

용도

개요

Salbutamol 또는 albuterol은 천식 및 만성 폐색 성 폐 질환과 같은 상태에서 기관지 경련의 완화에 사용되는 단기 작용 β2-adrenergic receptor agonist입니다. 그것은 다른 상표 이름 중 Ventolin으로 판매됩니다. Salbutamol은 1968 년에 판매 될 첫 번째 선택적 β2 수용체 작용제였습니다.이 제품은 Allent & Hanburys가 Ventolin이라는 브랜드로 처음 판매되었습니다. 이 약물은 즉각적인 성공을 거두어 그 이후로 천식 치료에 사용되었습니다.

용도

살부타몰(INN: salbutamol) 또는 알부테롤(USAN: albuterol)은 빠르게 반응하는 교감신경β2수용체작용제이며 천식과 만성 폐쇄성 폐질환과 같은 기관지 경련을 가라앉히는 데에 쓰인다.

개요

Albuterol is a β2-adrenergic sympathomimetic amine with pharmacological similarities to terbutaline. It has almost no effect on β1-adrenoreceptors of the heart. It has expressed broncholytic effects—prevention or relief of bronchi spasms, lowering respiratory tract resistance, and increasing the vital capacity of the lungs.

역사

In 1968, Salbutamol (Albuterol) will become the most prescribed bronchodilator in the world. Discovered by DAVID HARTLEY, DAVID JACK, LAWRENCE LUNTZ AND ALEXANDER RITCHIE of the British company Allen and Hanburys, former division of Glaxo-smith kline marketed under the name of Ventolin; who will stop the acute crisis and save the life of the asthmatic.In 2008, a study shows its action in cases of neuromuscular diseases.In February 2020, the U.S. Food and Drug Administration (FDA) approved the first generic of an albuterol sulfate inhalation aerosol for the treatment or prevention of bronchospasm in people four years of age and older with reversible obstructive airway disease and the prevention of exercise-induced bronchospasm in people four years of age and older. The FDA granted approval of the generic albuterol sulfate inhalation aerosol to Perrigo Pharmaceutical.

용도

immune suppressant, antineoplastic, antiviral

일반 설명

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706019, T706030, T706020. Salbutamol is classified under the β-agonist group of chemicals which are known to possess powerful pharmacological activities.

potential migration in soil or water
effects on animal, aquatic, and plant life
and conformance with environmental and public health regulations.
상호 작용Following single-dose IV or oral administration of albuterol to healthy individuals who had received digoxin for 10 days, a 16-22% decrease in serum digoxin concentration was observed.Epinephrin, other orally inhaled sympathomimetic amines: May increase sympathomimetic effects and risk of toxicity. Avoid use together /with albuterol/.MAO inhibitors, tricyclic antidepressants: Serious cardiovascular effects and risk of toxicity. Avoid use together /with albuterol/.Propanolol, other beta blockers: May antagonize effects of albuterol. Use together cautiously.
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 23(SRC), determined from a water solubility of 1.41X10+4 mg/L(2) and a regression-derived equation(3), indicates that albuterol is expected to have very high mobility in soil(SRC). However, the estimated pKa of albuterol is 10(4), indicating that this compound may partially exist in the protonated form in the environment. Cations generally adsorb more strongly to organic carbon and clay than their neutral counterparts(5), suggesting that mobility may be much lower in some soils(SRC). Volatilization of albuterol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.4X10-16 atm-cu m/mole(SRC), using a fragment constant estimation method(6). Albuterol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 8.9X10-9 mm Hg(SRC), determined from a fragment constant method(7).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 23(SRC), determined from a water solubility of 1.41X10+4 mg/L(2) and a regression-derived equation(3), indicates that albuterol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 6.4X10-16 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). The pKa1 and pKa2 of albuterol are 9.2 and 10.7(5), respectively, indicating that this compound will partially exist in the protonated in the environment and cations generally adsorb more strongly to suspended solids and sediment than their neutral counterparts(6). According to a classification scheme(7), an estimated BCF of 3(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), albuterol, which has an estimated vapor pressure of 8.9X10-9 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase albuterol may be removed from the air by wet and dry deposition(SRC).
유해 작용The primary adverse effects of albuterol therapy are tremors and nervousness, and although they can occur at any age, they are predominantly observed in children aged 2 to 6. Tremors result from the activation of β2-receptors found on motor nerve terminals, leading to an increase in intracellular cAMP. These adverse effects occur in approximately 1 in every 5 patients. Additional adverse effects include insomnia and nausea, which occur in approximately 1 in every 10 patients. Less common adverse effects may include fever, bronchospasm, vomiting, headache, dizziness, cough, allergic reactions, otitis media, epistaxis, increased appetite, urinary tract infections, dry mouth, gas, hyperhidrosis, pain, dyspepsia, hyperactivity, chills, lymphadenopathy, ocular pruritus, sweating, conjunctivitis, and dysphonia. Albuterol also has been shown to increase blood pressure levels and may cause hypokalemia. Although rare, occurrences of increased blood glucose concentrations, prolonged QTc interval, and ST-segment depression have been reported.
노출 경로Systemic absorption is rapid following aerosol administration.
독성 요약Signs and Symptoms of OverdoseSalbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increases cAMP production by activating adenylate cyclase, and the actions of salbutamol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentration leads to a smooth muscle relaxation and bronchodilation. In addition to bronchodilation, salbutamol inhibits the release of bronchoconstricting agents from mast cells, inhibits microvascular leakage, and enhances mucociliary clearance.
Effluent ConcentrationsAlbuterol has been reported in unspecified influent waters at a maximum concentration of 0.17 ug/L(1). Concentrations of <0.025 to 0.17 ug/L have been reported in unspecified sewage effluents(2).
Soil Adsorption/MobilityThe Koc of albuterol is estimated as 23(SRC), using a water solubility of 1.41X10+4 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that albuterol is expected to have very high mobility in soil. However, the estimated pKa1 and pKa2 values for albuterol are 9.2 and 10.7, respectively(4), indicating that this compound may partially exist in the protonated form in the environment. Cations generally adsorb more strongly to organic carbon and clay than their neutral counterparts(5), suggesting that mobility may be much lower in some soils(SRC).
Human Toxicity Excerpts/HUMAN EXPOSURE STUDIES/ During worldwide marketing experience, various congenital anomalies, including cleft palate and limb defects, have been reported in the offspring of patients being treated with albuterol. Some of the mothers were taking multiple medication during their pregnancies. No consistent pattern of defects can be discerned, and a relationship between albuterol use and congenital anomalies has not been established./HUMAN EXPOSURE STUDIES/ This study was designed to determine the threshold dose for toxicity, the potential for serious medical complications, and the medical care required after unintentional albuterol ingestion in children. This study was prospective and descriptive. Data were obtained on pediatric albuterol ingestions evaluated emergently as reported to three regional poison control centers. Data elements included dose ingested, physical findings, medical treatment, and outcome. During 18 months, 78 patients who ingested albuterol and who received urgent medical evaluation were identified. Mean age was 2.8 years. The amount ingested ranged from 0.2 to 8.8 mg/kg. The most commonly reported signs of toxicity were tachycardia (57%, 44/78), widened pulse pressure (50%, 27/54), hyperglycemia (50%, 12/24), agitation (45%, 35/78), low serum carbon dioxide (42%, 10/24), vomiting (26%, 20/78), and hypokalemia (26%, 9/35). We found a threshold dose of 1 mg/kg for three or more signs of toxicity (P < 0.01). No patient required any specific treatment for toxicity. Seventy-two percent of patients were discharged from medical care within six hours of ingestion. Albuterol overdose in children causes a variety of cardiovascular, neuromuscular, and metabolic effects that are usually benign. The threshold dose for the development of three or more signs of toxicity is 1 mg/kg or three to 10 times the recommended daily dose. Toxicity is short-lived and does not require specific therapy or hospital admission in most cases./SIGNS AND SYMPTOMS/ signs and symptoms of overdose including exaggeration of common adverse reactions, particularly angina, hypertension, hypokalemia, and seizures. Cardiac arrest may occur./SIGNS AND SYMPTOMS/ Albuterol also has been reported to cause maternal and fetal tachycardia and hyperglycemia (especially in patients with diabetes), as well as maternal hypotension, acute congestive heart failure, pulmonary edema, and death./CASE REPORTS/ Albuterol overdose can lead to tachycardia, hypotension, tremor, hypokalemia, and hyperglycemia in children. Hypoglycemia had been previously reported in only one child. A 3-year-old boy who ingested high-dose albuterol in this report /is described/. On arrival to the emergency department, the child was agitated and had noticeable restlessness, sinus tachycardia, mild hypokalemia (3.2 mEq/L), and hyperglycemia (187 mg/dL). Activated charcoal and intravenous hydration were given, and electrocardiogram monitoring was performed. Sinus tachycardia resolved within 4 to 6 hours. Hypoglycemia (45 mg/dL) was identified 4 hours after admission. The child recovered uneventfully within 24 hours with glucose replacement. This case suggests that hypoglycemia could be a late complication of acute albuterol overdosethus, the period of observation should be extended in these cases.
Artificial Pollution SourcesAlbuterol's production and use as a bronchodilator(1) may result in its release to the environment through various waste streams(SRC).
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Drug Induced Liver InjuryDrug Induced Liver Injury Rank (DILIrank 2.0)AlbuterolvNo-DILI-concernNo matchDOI:10.1016/j.drudis.2016.02.015
Environmental BioconcentrationAn estimated BCF of 3 was calculated for albuterol(SRC), using a water solubility of 1.41X10+4 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
수질 위해 등급(WGK)3
RTECS 번호ZE4400000
운송 번호(UN)3249
관세 코드2922504500
위험 문구(R)22-39/23/24/25-23/24/25-11
위험 표시Xn,T,F
안전 문구(S)36-45-36/37-16-7
포장분류III
위험 등급6.1(b)Acute Tox. 4 OralAquatic Chronic 3Eye Irrit. 2Skin Sens. 1B
저장 분류11 - Combustible Solids
유해 물질 데이터18559-94-9(Hazardous Substances Data)