2,4,5-T-isobutyl

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Extinguish fire using agent suitable for type of surrounding fire. /2,4,5-T amine, ester, or salt/

WATER, FOAM, DRY CHEM, CARBON DIOXIDE. ... WATER OR FOAM MAY CAUSE FROTHING. /2,4,5-T ESTERS/

Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. /2,4,5-T amine, ester, or salt/

Water spill: If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /2,4,5-T amine, ester, or salt/

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number F027, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste. /2,4,5-T cmpd/

Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/

Group II Containers: Noncombustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/

If material /is not/ involved in a fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. /2,4,5-T amine, ester, or salt/

Keep upwind. ... Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /2,4,5-T amine, ester, or salt/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

8 hr Time Weighted Avg (TWA): 10 mg/cu m. /2,4,5-T/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /2,4,5-T/

A4; Not classifiable as a human carcinogen. /2,4,5-T/

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Wear appropriate chemical protective ... boots and goggles. /2,4,5-T amine, ester, or salt/

... Rubber gloves ... /2,4,5-T esters/

LC50 Lepomis macrochirus (bluegill) 12 mg/l/24 hr (50% emulsion of 2,4,5-T esters) /Conditions of bioassay not given/

LC50 Salmo gairdnerii (rainbow trout) 9.5 mg/l/48 hr (50% emulsion of 2,4,5-T esters) /Conditions of bioassay not given/

2,4,5-T ESTERS ARE RAPIDLY HYDROLYZED AFTER SPRAYING, & THE 2,4,5-T IS THEN FURTHER DECOMPOSED BY BACTERIAL ACTION. THE MAJOR PRODUCT OF 2,4,5-T PHOTODECOMPOSITION IS 2,4,5-TRICHLOROPHENOL. OTHER PRODUCTS IDENTIFIED INCLUDED 4,6-DICHLORORESORCINOL, 4-CHLORORESORCINOL, 2,4,5-TRICHLOROANISOLE. /2,4,5-T ESTERS/

The chlorophenoxy herbicides have produced contact dermatitis in man ... . /Chlorophenoxy compounds/

INHALATION OF SPRAY MAY CAUSE BURNING SENSATIONS IN THE NASOPHARYNX & CHEST, & COUGHING MAY RESULT. PROLONGED INHALATION SOMETIMES CAUSES DIZZINESS. /CHLOROPHENOXY COMPOUNDS/

WHEN INGESTED, HIGH CONCENTRATIONS OF CHLOROPHENOXY COMPOUNDS MAY IRRITATE THE MOUTH & THROAT, & GI TRACT. ... CHEST PAIN (FROM ESOPHAGITIS), ABDOMINAL PAIN & DIARRHEA COMMONLY ENSUE. ... ABSORBED CHLOROPHENOXY COMPOUNDS HAVE CAUSED FIBRILLARY MUSCLE TWITCHING, SKELETAL MUSCLE TENDERNESS, & MYOTONIA ... INGESTION OF VERY LARGE AMOUNTS HAS PRODUCED METABOLIC ACIDOSIS, FEVER, TACHYCARDIA, HYPERVENTILATION, VASODILATATION & SWEATING. PARTICULAR CASES HAVE BEEN CHARACTERIZED BY COMA & CONVULSIONS. /CHLOROPHENOXY COMPOUNDS/

Phenoxyherbicides including (2,4,5-trichlorophenoxy)acetic acid have been widely used in New Zealand for over 30 years. In the light of Swedish studies reporting an association between exposure to phenoxyherbicides or chlorophenols and soft tissue sarcoma, a case-control study was undertaken that involved interviewing 82 subjects (cases) with soft tissue sarcoma and 92 controls with other types of cancer. For those potentially exposed to phenoxyherbicides for more than 1 day not in the 5 years before cancer registration, the estimate of relative risk was 1.3, with 90% confidence limits of 0.6-2.5. The comparable relative risk estimate for chlorophenol exposure was 1.5, with 90% confidence limits of 0.5-4.5. The discovery of cases in trichlorophenol manufacturing plants in the United States lended support to the Swedish findings but further studies are needed to conclude whether human exposure to these chemicals truly increases the risk of soft tissue sarcoma. /Phenoxyherbicides/

A previous case-control study which used the occupational information available on the New Zealand Cancer Registry found that agricultural workers were at increased risk of developing non-Hodgkin's lymphoma. The findings are now presented for the second phase of the study which entailed interviewing 83 cases of non-Hodgkin's lymphoma registered under code 202 of the International Classification of Diseases together with 168 controls with other types of cancer and 228 general population controls. The findings for the two control groups were similar, and there were no significant differences between cases and controls regarding potential exposure to phenoxyherbicides (odds ratio= 1.4, 90% confidence limits 0.7-2.5, p= 0.26) or chlorophenols (odds ratio= 1.3, 90% confidence limits 0.6-2.7, p= 0.39). The odds ratio for fencing work, necessitating exposure to several potential risk factors including arsenic and sodium pentachlorophenate was 2.0 (90% confidence limits 1.3-3.0, p= 0.01). The odds ratio for employment in a meat works, necessitating potential exposure to 2,4,6-trichlorophenol and zoonotic viruses, was 1.8 (90% confidence limits 1.1-3.1, p= 0.04). There was a significant statistical interaction between the risks associated with these two activities, the odds ratio for involvement in both activities compared with involvement in neither being 5.7 (90% confidence limits 2.3, p= 0.03). /Phenoxyherbicides, chlorophenols, arsenic, and sodium pentachlorophenate/

... Assuming the densities of Purple and Pink were similar to Orange, one gallon of Purple or Pink would have weighed approximately 10.7 pounds. The specified formulation of Purple was ... 20% by weight the isobutyl ester of 2,4,5-T, so one gallon of the specified formulation of Purple would contain approximately ... 2.1 pounds of the isobutyl ester of 2,4,5-T. Therefore, Purple applied at 1.5 gallons per acre is estimated to have released a maximum of ... 3.2 pounds per acre of the isobutyl ester of 2,4,5-T. The specified formulation of Pink was 40% by weight the isobutyl ester of 2,4,5-T, so one gallon of the specified formulation of Pink would contain approximately 4.3 pounds of the isobutyl ester of 2,4,5-T. Therefore, Pink applied at 1.5 gallons per acre is estimated to have released a maximum of 6.5 pounds per acre of the isobutyl ester of 2,4,5-T.

Components of the herbicide Agent Orange: 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and their esters, and the contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related chemicals were tested for mutagenicity using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537. All chemicals were tested by modified Ames Salmonella plate incorporation assay. Tests were conducted in the absence & presence of S9 mix. No mutagenic activity was observed for any of the chemicals tested. Doses for 2,4,5-T isobutyl ester: 0.0, 100, 333 & 1000, 3333 & 10000 ug/plate.

Concern about the toxicology of 2,4,5-T & related compounds centers primarily on teratogenic action in exptl animals. The 1st studies to reveal this action were ... conducted with a sample of 2,4,5-T that contained a high level (about 30 ppm) of contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin. This contaminant is formed during synthesis of the trichlorophenol precursor. /Chlorophenoxy compounds/

ANIMALS POISONED PRESENT AN OVERALL PICTURE OF LOSS OF APPETITE, LOSS OF WEIGHT, DEPRESSION, /POOR/ ... APPEARANCE, GENERAL TENSENESS & MUSCULAR WEAKNESS, PARTICULARLY IN THE HIND LEGS. LARGE ORAL DOSES ELICIT VOMITING IN THOSE SPECIES CAPABLE OF DOING SO. /CHLOROPHENOXY DERIV OF FATTY ACIDS/

Pathologic changes in exptl animals killed by the chlorophenoxy compounds are generally nonspecific with irritation of stomach & some liver & kidney injury. /Chlorophenoxy compounds/

Classification of carcinogenicity: 1) evidence in humans: limited; Overall summary evaluation of carcinogenic risk to humans is Group 2B: The agent is possibly carcinogenic to humans. /Chlorophenoxy herbicides; From table/

A4; Not classifiable as a human carcinogen. /2,4,5-T/

From limited data available, it may be concluded that any phenoxy herbicide, whether applied as ester or as dimethylamine salt formulations, may be chemically transformed to the same phenoxyalkanoic anion in soil and water at rates dependent on pH. These anions would presumably reassociate with a variety of inorganic cations present in the soil to maintain electrical neutrality, and then undergo leaching and biological degradation. /Phenoxy esters/

Exposure to chlorophenoxy herbicides may occur through inhalation, skin contact or ingestion. /Chlorophenoxy herbicides/

... Occupational exposure to chlorophenoxy herbicides ... is known to have occurred during their production, formulation, application & disposal. /Chlorophenoxy herbicides/

F027; As stated in 40 CFR 261.31, discarded unused formulations containing tri-, tetra-, or pentachlorophenol or discarded unused formulation containing compounds derived from these chlorophenols. (This listing does not include formulations containing hexachlorophene synthesized from prepurified 2,4,5-trichlorophenol as the sole component.). /2,4,5-T/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). /2,4,5-T Esters/

2,4,5-T Esters are designated as hazardous substances under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. /2,4,5-T Esters/

(ME) MAINE 70 ug/l /2,4,5-T/

(MN) MINNESOTA 70 ug/l /2,4,5-T/