Dexpropranolol

역사Scottish scientist James W. Black developed propranolol in the 1960s. It was the first beta-blocker effectively used in the treatment of coronary artery disease and hypertension.Propranolol was patented in 1962 and approved for medical use in 1964. It is on the World Health Organization's List of Essential Medicines. In 2023, it was the 69th most commonly prescribed medication in the United States, with more than 9 million prescriptions.

용도Propranolol has been studied most carefully in experiments and in clinics. It is used for ventricular tachycardia, arrhythmia caused by digitalis drug overdose, or as a result of thyrotoxosis or excess catecholamine activity. Despite the fact that there are a number of β-adrenoblockers, propranolol is considered the first choice of drugs although other blockers of calcium blockers can be just as effective.

일반 설명R(+)-PROPRANOLOL HCL(Inderal, others) is the prototypical andnonselective β-blocker. It blocks the β1- and β2-receptorswith equal affinity, lacks ISA, and does not block β-receptors. R(+)-PROPRANOLOL HCL like the other β-blockers discussed,is a competitive blocker whose receptor-blockingactions can be reversed with sufficient concentrations of β-agonists.