나이트릴로트라이아세트산 트라이나트륨

Liquid; Dry Powder; Liquid

White solid; [ICSC] Colorless or white solid; Slightly hygroscopic; [CHEMINFO]

WHITE CRYSTALLINE POWDER.

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P203, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P318, P330, P337+P317, P405, and P501 (click each P-code to see the statement)

Warning

H290 (10.3%): May be corrosive to metals [Warning Corrosive to Metals]

P203, P234, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P318, P330, P337+P317, P390, P405, P406, and P501 (click each P-code to see the statement)

Chemical: Glycine, N,N-bis(carboxymethyl)-, trisodium salt

Hazard Traits - Carcinogenicity

Glycine, N,N-bis(carboxymethyl)-, sodium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine, N,N-bis(carboxymethyl)-, sodium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Trisodium nitrilotriacetate (EC: 225-768-6)

Trisodium nitrilotriacetate: Does not have an individual approval but may be used under an appropriate group standard

A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Possible human carcinogen; [ICSC] A skin, eye, nose, and throat irritant; Not sensitizing to human skin; High-dose feeding produces lesions of the urinary tract in mice and kidney lesions in rats; No evidence of reproductive or developmental toxicity in rats or rabbits; Emergency treatment: Oxalic acid; Oxalic acid is an irritant that, after ingestion, may cause kidney damage, hypocalcemia, and hepatic necrosis; [HSDB] An eye irritant; [eChemPortal: ESIS] Not irritating to rabbit or human skin; Irritating to rabbit eyes; Nephrotoxic in rats; [IUCLID] Mutagenic, tumorigenic, and toxic to reproduction; Causes changes in liver and bladder weights, erythrocyte count, and renal tubules in repeated dose studies of rats; [RTECS] May cause skin and eye irritation; Harmful if swallowed; [Aldrich MSDS] See Nitrilotriacetic acid.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Nitrilotriacetic acid, trisodium salt is found on List D. Case No: 4014; Pesticide type: Antimicrobial; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Nitrilotriacetic acid, trisodium salt; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.

Met. Corr. 1 (10.3%)

Acute toxicity - category 4

Acute toxicity (Oral) - Category 4

Carc. 2

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

The development of renal tumors was examined in rats given 1000 ppm N-ethyl-N-hydroxyethylnitrosamine (NEELA) and then 30,000, 10,000 or 3,000 ppm of trisodium nitrilotriacetate monohydrate (Na3 X NTA X H20) in their food. The incidences of renal tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine for 2 wk and then 30,000, 10,000 and 3,000 ppm trisodium nitrilotriacetate monohydrate for 30 wk were 100, 86 and 22%, respectively, while they were 16 and 0% in rats treated with N-ethyl-N-hydroxyethylnitrosamine or 30,000 ppm trisodium nitrilotracetate monohydrate at 30,000 or 10,000, but not 3,000 ppm, also incr the size and number of renal tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine and trisodium nitrilotriacetate monohydrate 30,000 ppm, but not 10,000 or 3,000 ppm also induced hydronephrosis in rats irrespective of whether they were treated with N-ethyl-N-hydroxyethylnitrosamine. Thus, trisodium nitrilotriacetate monohydrate has a dose-related effect on the kidney. /Trisodium nitrilotriacetate monohydrate/

ORAL ADMIN OF TRISODIUM NITRILOTRIACETATE (0.01, 0.10, OR 1% WT/VOL IN DRINKING WATER) DID NOT ENHANCE THE PATHOLOGICAL EFFECTS OF LEAD ON THE RAT RENAL SYSTEM; HOWEVER, RATS GIVEN 0.01 OR 0.10% WITH OR WITHOUT LEAD WERE HYPERGLYCEMIC.

The effects of the renal tumor promoters; beta-cyclodextrin, DL-serine, basic lead acetate, trisodium nitrilotriacetate monohydrate & potassium bromate, & diethylene glycol as a negative control, on early stage of renal carcinogenesis were investigated in unilaterally nephrectomized male Wistar rats after N-ethyl-N-hydroxyethylnitrosamine admin. Wistar male rats were fed 1000 ppm N-ethyl-N-hydroxyethylnitrosamine diet for 2 wk & the left kidney was removed at week 3, then the animals were divided into 7 groups of 15 rats each. These groups received the following treatments: 1000 ppm lead acetate, 10000 ppm trisodium nitrilotriacetatemonohydrate or 500 ppm potassium bromate diet for 18 wk from wk 3; 45 mg/100 g bw/day of beta-cyclodextrin injected sc for 7 days; 100 mg/100 g bw of DL-Serine injected sc biweekly for 6 weeks; 5% diethylene glycol in drinking water as a negative control for two days. Five rats in each group were killed at wk 8, 12 & 20 & their kidneys were examined histologically. At wk 20, the avg numbers of adenomatous hyperplasias seen as preneoplastic lesions in the beta-C, DL-Serine, lead acetate, trisodium nitrilotriacetate monohydrate or potassium bromate groups were significantly higher than those in the diethylene glycol or control groups. Thus within a relatively short period of 20 wk, promoting effects of chemicals can be detected as a significant incr of adenomatous hyperplasias in this model. /Trisodium nitrilotriacetate monohydrate/

The dose-dependent effect of trisodium nitrilotriacetate monohydrate as a promoter in two stage carcinogenesis in the urinary bladder of male Wistar rats was investigated. Carcinogenesis was initiated by administration of 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine in the drinking water for 4 weeks, then trisodium nitrilotriacetate monohydrate was given at 1%, 0.5% and 0.3% in the diet for 28 weeks, and rats were killed in week 32. The incidences and numbers of preneoplastic lesions (papillary or nodular hyperplasia, PN hyperplasia) in rats treated with 0.3% to 1% trisodium nitrilotriacetate monohydrate increased progressively with increasing concentration of trisodium nitrilotriacetate monohydrate. The incidences of papillomas in rats treated with 1% and 0.5% trisodium nitrilotriacetate monohydrate in the diet and the incidence of transitional cell carcinoma of the urinary bladder in the rats treated with 1% trisodium nitrilotriacetate monohydrate (P< 0.05) were significantly higher than those in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine only. Administration of various doses of trisodium nitrilotriacetate monohydrate without N-butyl-N-(-hydroxybutyl)nitrosamine did not cause any histological changes (papillary or nodular hyperplasia, papilloma or transitional cell carcinoma) in the urinary bladder. These findings showed that trisodium nitrilotriacetate monohydrate is a potent promoter of urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats, and that its effect is dose-dependent. /Trisodium nitrilotriacetate monohydrate/

For more Interactions (Complete) data for TRISODIUM NITRILOTRIACETATE (9 total), please visit the HSDB record page.

EC50; Species: Anacystis aeruginosa (Blue-Green Algae) 100000 cells/mL; Conditions: freshwater, static, 23 °C; Concentration: 180000-320000 ug/L for 96 hr; Effect: growth, general />99% purity formulation/

EC50; Species: Chlorella vulgaris (Green Algae) exponential growth phase, 5x10+4 cells/mL; Conditions: freshwater, static, 22 °C; Concentration: 560000-1000000 ug/L for 96 hr; Effect: growth, general />99% purity formulation/

LC50; Species: Xenopus laevis (African Clawed Frog) age 3-4 wk; Conditions: freshwater, renewal, 21 °C; Concentration: 560000-1000000 ug/L for 96 hr />99% purity formulation/

EC50; Species: Daphnia magna (Water Flea) age 1 day; Conditions: freshwater, renewal, 19 °C; Concentration: 180000 ug/L for 21 days; Effect: reproduction, general />99% purity formulation/

For more Ecotoxicity Values (Complete) data for TRISODIUM NITRILOTRIACETATE (37 total), please visit the HSDB record page.

/OTHER TERRESTRIAL SPECIES/ Studies on 4 succeeding generations of the snail Helisoma trivolvis indicated that nominal concentrations up to 100 mg/L were not acutely toxic. Concentrations above 25 mg/L imposed a stress on growth and fecundity of snails.

Burning sensation. Sore throat. Cough. Laboured breathing. Shortness of breath.

Redness. Skin burns. Pain.

Redness. Pain. Severe deep burns.

Abdominal pain. Burning sensation. Shock or collapse.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. /Nitrilotriacetic acid trisodium monohydrate/[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=18662-53-8]

Trisodium nitrilotriacetate is readily decomp by soil microorganisms under anaerobic or aerobic conditions. Nitrilotriacetate-N converted to nitrate under aerobic conditions, indicating use of detergents containing nitrilotriacetate leading to nitrate enrichment of water resources.

A nitrilotriacetate (NTA)-degrading pseudomonas species was shown to degrade Ca, Mn, Mg, Cu, Zn, Cd, Fe and Na chelates of nitrilotriacetate at nearly equal rates when the appropriate metal concn are low enough to avoid toxicity from the freed metal

In an aerated sewage lagoon, trisodium nitrilotriacetate breakdown was temperature dependent: 93% at 15 °C; 47% at 5 °C; and 22% at 0.5 °C.

/LABORATORY ANIMALS: Acute Exposure/ TRISODIUM NITRILOACETATE PRODUCED EMESIS IN 50% OF DOGS GIVEN 6.0 MG/KG. INSTILLATION OF 3 MG OF A 35% FORMULATION INTO RABBIT EYES PRODUCED ONLY DIFFUSE AREAS OF CORNEAL TRANSLUCENCY AND CONJUNCTIVITIS WHEN LEFT UNRINSED.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ EFFECT OF NITRILOTRIACETATE ON CATION BALANCE OF WEANLING RATS FED TRISODIUM NITRILOTRIACETATE AFTER 4 WK WAS RENAL TOXICITY, EXPRESSED AS KIDNEY-TO-BODY-WT RATIO.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ RATS FED VARIOUS LEVELS OF NITRILOTRIACETATE AS EITHER H3NTA OR TRISODIUM NITRILOTRIACETATE FOR 4 WK. URINE PH INCR BY HIGH DOSES OF TRISODIUM NITRILOTRIACETATE, DECR BY H3NTA. 1000 MICROMOLES TRISODIUM NITRILOTRIACETATE/100 G/DAY CAUSED HEMATURIA.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ EXTREMELY HIGH CONCN OF TRISODIUM NITRILOTRIACETATE (APPROX 7500 PPM) INCORPORATED INTO DIET OF RATS FOR 90 DAYS PRODUCED KIDNEY LESIONS, BUT NO OTHER SIGNIFICANT ABNORMALITIES.

For more Non-Human Toxicity Excerpts (Complete) data for TRISODIUM NITRILOTRIACETATE (21 total), please visit the HSDB record page.

Evaluation: There is inadequate evidence in humans for the carcinogenicity of nitrilotriacetic acid and its salts. There is sufficient evidence in experimental animals for the carcinogenicity of nitrilotriacetic acid and its sodium salts. Overall evaluation: Nitrilotriacetic acid and its salts are possibly carcinogenic in humans (Group 2B). /Nitrilotriacetic acid and its salts/

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Nitrilotriacetic acid, trisodium salt is found on List D. Case No: 4014; Pesticide type: Antimicrobial; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Nitrilotriacetic acid, trisodium salt; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.

TRISODIUM AMINOTRIACETATE WAS WELL ABSORBED IN RATS AND DOGS, & EXCRETED UNCHANGED IN URINE. THE AMT (8 UG/G BONE), WHICH WAS INCORPORATED INTO RAT SKELETON IN COMBINATION WITH CA2+ REPRESENTED ONLY 0.007% OF THE 24 HR TURNOVER OF CALCIUM IN THAT TISSUE, AND WAS CONSIDERED UNLIKELY TO AFFECT DEVELOPMENT ADVERSELY.

RATS WERE GIVEN TRISODIUM NITRILOTRIACETATE AT DIETARY LEVELS OF 0.05, 0.1, 0.3, 0.5, 0.75, OR 2% FOR 42 & 30 DAYS. NITRILOTRIACETATE DID NOT ACCUMULATE IN BLADDER TISSUES TO ANY GREATER EXTENT THAN IN HEART AND LIVER, EVEN WHEN URINARY NTA LEVELS WERE EQUAL TO OR GREATER THAN 200 TIMES THOSE IN PLASMA.

In a whole body autoradiographic study, 0.93 Mg (1-(14)C-acetate) NTA, trisodium salt was administered intravenously to NMRI albino mice and the same amount orally to C57BI mice; heavy accumulation of radioactivity occurred in the skeleton, which persisted for 48 h, the longest interval studied.

Used as chelating agent in bleaching and as a sequestrant builder; Also used in tanning, synthetic rubber, textiles, pharmaceuticals, low phosphate and phosphate-free detergents, and in boiler-water treatment; [HSDB] Used for extraction, refining, and processing of metals; in the paper-pulp-board industry; and as an additive to construction materials; [IUCLID]

Pulp and Paper Processing [Category: Industry]

For trisodium nitrilotriacetate (USEPA/OPP Pesticide Code: 039106) there are 0 labels match. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

CHELATING AGENT IN BLEACHING, SYNTHETIC RUBBER, TANNING, TEXTILES, PHARMACEUTICALS

Sequestrant

Substitute for pentasodium triphosphate in formulation of low-phosphate detergents...in phosphate-free detergents

2023: 25,000,000 - <40,000,000 lb

(1972) 2.18X10+10 G (NITRILO ACIDS & SALTS

(1975) 4.35X10+10 G (NITRILO ACIDS & SALTS

Glycine, N,N-bis(carboxymethyl)-, trisodium salt is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#2682]

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Glycine, N,N-bis(carboxymethyl)-, sodium salt. Aggregated National Production Volume: 10 to < 50 million pounds.

REACTION OF HYDROGEN CYANIDE WITH FORMALDEHYDE AND AMMONIA

By the reaction of ammonia, NCHO, and sodium cyanide with sodium hydroxide

All Other Basic Organic Chemical Manufacturing

Glycine, N,N-bis(carboxymethyl)-, sodium salt (1:3): ACTIVE

TRISODIUM SALT OF NITRILOTRIACETIC ACID HAS BEEN TESTED AND FOUND EFFECTIVE IN BINDING COPPER AND ZINC.

TRISODIUM SALT OF NTA WAS PROPOSED AS A SUBSTITUTE FOR PHOSPHATE IN DETERGENTS.